Our modern lives have been radically revolutionized by mechanical or electric machines that redefine and recreate the way we work, communicate, entertain, and travel. Whether being perceived or not, human-machine interfacing (HMI) technologies have been extensively employed in our daily lives, and only when the machines can sense the ambient through various signals, they can respond to human commands for finishing desired tasks. Metamaterials have offered a great platform to develop the sensing materials and devices from different disciplines with very high accuracy, thus enabling the great potential for HMI applications. For this regard, significant progresses have been achieved in the recent decade, but haven’t been reviewed systematically yet. In the Review, we introduce the working principle, state-of-the-art sensing metamaterials, and the corresponding enabled HMI applications. For practical HMI applications, four kinds of signals are usually used, i.e., light, heat, sound, and force, and therefore the progresses in these four aspects are discussed in particular. Finally, the future directions for the metamaterials-based HMI applications are outlined and discussed.