Abstract:The tumor microenvironment (TME) plays a central role in tumor progression and metastasis, thereby regulating disease prognosis and patient outcomes. Systematic investigation of the multitude of factors influencing the solid TME is necessary to understand the mechanisms of disease progression. Particularly, the role of cancer cell–matrix interactions and multi-directional crosstalk between tumor and stromal cells have gained attention as potential therapeutic targets. Toward this end, engineered two-dimensiona… Show more
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