Millworker Lung Function Decline Following A Large Chlorine Spill Event

Clark, Kathleen; Chanda, Debjani; Cai, Bo; Mohr, Lawrence C.; Karmaus, Wilfried; Gibson, Jerome; Svendsen, Erik

doi:10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4703

C50. Update on Occupational Lung Diseases 2010

DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4703

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Millworker Lung Function Decline Following A Large Chlorine Spill Event

Kathleen Clark¹,

Debjani Chanda²,

Bo Cai³

et al.

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2016

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“…In an earlier preliminary analysis, we observed possible "chlorine effects" within this mill worker population immediately after the accident (23). Here, we refined our spirometry selection criteria to improve regression models and reduce some of the inherent bias contained within this secondary data set.…”

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Lung Function before and after a Large Chlorine Gas Release in Graniteville, South Carolina

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Rationale: On January 6, 2005 a train derailment led to an estimated 54,915-kg release of chlorine at a local textile mill in Graniteville, South Carolina.Objectives: We used the employee health spirometry records of the textile to identify enduring effects of chlorine gas exposure resulting from the incident on the lung function of workers employed at the textile mill.Methods: Spirometry records from 1,807 mill workers (7,332 observations) were used from 4 years before and 18 months after the disaster. Longitudinal analysis using marginal regression models produced annual population mean estimates for FEV 1 , FVC, and FEV 1 /FVC ratio. Covariate adjustment was made for sex, age, smoking, height, season tested, technician, obesity, season 3 year interactions, and smoker 3 year interactions. The increased prevalence of mill workers having accelerated FEV 1 decline was also evaluated after the chlorine spill. Measurements and Main Results:In the year of the accident, we observed a significant reduction in mean FEV 1 (-4.2% predicted; P = 0.019) when compared with the year before the incident. In the second year, partial recovery in the mean FVC % predicted level was seen, but the cohort's average FEV 1 /FVC ratio continued to decrease over time. Severe annual FEV 1 decline was most prevalent in the year of the accident, and independent of mill worker smoking status. Conclusions:The Graniteville mill worker cohort revealed significant reductions in lung function immediately after the chlorine incident. Improvement was seen in the second year; but the proportion of mill workers experiencing accelerated FEV 1 annual decline significantly increased in the 18 months after the chlorine incident.

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Lung Function before and after a Large Chlorine Gas Release in Graniteville, South Carolina

et al. 2016

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Millworker Lung Function Decline Following A Large Chlorine Spill Event

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Lung Function before and after a Large Chlorine Gas Release in Graniteville, South Carolina

Lung Function before and after a Large Chlorine Gas Release in Graniteville, South Carolina

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