Millimeter size patch behavior of gecko-inspired reversible adhesive

Tamelier, John; Chary, Sathya; Turner, Kimberly L.; Yu, Jing; Das, Saurabh; Israelachvili, Jacob N.

doi:10.1109/icsens.2011.6127159

Cited by 5 publications

(13 citation statements)

References 12 publications

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“…Topography and surface contact area play a large role in final adhesive forces 19 . Hydrogel based adhesives demonstrate enhancement via interlocking mechanisms activated by swelling of PEG components 50 .…”

Section: Discussionmentioning

confidence: 99%

“…Topography and surface contact area play a large role in final adhesive forces. 19 Hydrogel based adhesives demonstrate enhancement via interlocking mechanisms activated by swelling of PEG components. 50 Surface roughness is critical to mucoadhesive properties 19,50 and mucosa-material interaction is multifactorial, with contributions from moisture, surface roughness, and surface area/shape.…”

Section: Discussionmentioning

confidence: 99%

“…19 Hydrogel based adhesives demonstrate enhancement via interlocking mechanisms activated by swelling of PEG components. 50 Surface roughness is critical to mucoadhesive properties 19,50 and mucosa-material interaction is multifactorial, with contributions from moisture, surface roughness, and surface area/shape. The gecko's ability to adhere to surfaces using setae on its feet, involves factors including water contact angle, Van der Waals forces, capillary forces, and geometry.…”

Section: Discussionmentioning

confidence: 99%

“…These new materials are manufactured by adapting flocking technology from the textile industry whereby short, vertical fibers are affixed to a base layer to design the composite construct 17 . These composites can potentially provide improved, reversible adhesion compared to traditional bio‐polymers 18,19 . Originally envisioned as adhesive tapes or as stability mechanisms in robotic climbers, they can also function as scaffolds in tissue engineering 20 …”

Section: Introductionmentioning

confidence: 99%

“…17 These composites can potentially provide improved, reversible adhesion compared to traditional bio-polymers. 18,19 Originally envisioned as adhesive tapes or as stability mechanisms in robotic climbers, they can also function as scaffolds in tissue engineering. 20 The design of a base layer for tissue sealants requires materials capable of conforming to the gross anatomy that control fluid permeability while maintaining biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

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Development of a Bioinspired, Self‐Adhering, and Drug‐Eluting Laryngotracheal Patch

et al. 2020

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Objectives/Hypothesis Novel laryngotracheal wound coverage devices are limited by complex anatomy, smooth surfaces, and dynamic pressure changes and airflow during breathing. We hypothesize that a bioinspired mucoadhesive patch mimicking how geckos climb smooth surfaces will permit sutureless wound coverage and also allow drug delivery. Study Design ex‐vivo. Methods Polycaprolactone (PCL) fibers were electrospun onto a substrate and polyethylene glycol (PEG) – acrylate flocks in varying densities were deposited to create a composite patch. Sample topography was assessed with laser profilometry, material stiffness with biaxial mechanical testing, and mucoadhesive testing determined cohesive material failure on porcine tracheal tissue. Degradation rate was measured over 21 days in vitro along with dexamethasone drug release profiles. Material handleability was evaluated via suture retention and in cadaveric larynges. Results Increased flocking density was inversely related to cohesive failure in mucoadhesive testing, with a flocking density of PCL‐PEG‐2XFLK increasing failure strength to 6880 ± 1810 Pa compared to 3028 ± 791 in PCL‐PEG‐4XFLK density and 1182 ± 262 in PCL‐PEG‐6XFLK density. The PCL‐PEG‐2XFLK specimens had a higher failure strength than PCL alone (1404 ± 545 Pa) or PCL‐PEG (2732 ± 840). Flocking progressively reduced composite stiffness from 1347 ± 15 to 763 ± 21 N/m. Degradation increased from 12% at 7 days to 16% after 10 days and 20% after 21 days. Cumulative dexamethasone release at 0.4 mg/cm2 concentration was maintained over 21 days. Optimized PCL‐PEG‐2XFLK density flocked patches were easy to maneuver endoscopically in laryngeal evaluation. Conclusions This novel, sutureless, patch is a mucoadhesive platform suitable to laryngeal and tracheal anatomy with drug delivery capability. Level of Evidence NA Laryngoscope, 131:1958–1966, 2021

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of a Bioinspired, Self‐Adhering, and Drug‐Eluting Laryngotracheal Patch

et al. 2020

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Vertical Anisotropic Microfibers for a Gecko-Inspired Adhesive

2012

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Geckos are able to adhere strongly and release easily from surfaces because the structurally anisotropic fibers on their toes naturally exhibit force anisotropy based on the direction of articulation. Here, semicircular fibers, with varying amounts of contact area on the two faces, are investigated to ascertain whether fiber shape can be used to gain anisotropy in shear and shear adhesion forces. Testing of 10-μm-diameter polydimethylsiloxane (PDMS) fibers against a 4-mm-diameter flat glass puck show that shear and shear adhesion forces were two to five times greater when in-plane movement caused the flat face, rather than the curved face, of the fiber to come in contact with the glass puck. The directional adhesion and shear force anisotropy results are close to theoretical approximations using the Kendall peel model and clearly demonstrate how fiber shape may be used to influence the properties of the adhesive. This result has broad applicability, and by combining the results shown here with other current vertical and angled designs, synthetic adhesives can be further improved to behave more like their natural counterparts.

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Friction and Adhesion of Gecko-Inspired PDMS Flaps on Rough Surfaces

Chary

Das

et al. 2012

Langmuir

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Geckos have developed a unique hierarchical structure to maintain climbing ability on surfaces with different roughness, one of the extremely important parameters that affect the friction and adhesion forces between two surfaces. Although much attention has been paid on fabricating various structures that mimic the hierarchical structure of a gecko foot, yet no systematic effort, in experiment or theory, has been made to quantify the effect of surface roughness on the performance of the fabricated structures that mimic the hierarchical structure of geckos. Using a modified surface forces apparatus (SFA), we measured the adhesion and friction forces between microfabricated tilted PDMS flaps and optically smooth SiO(2) and rough SiO(2) surfaces created by plasma etching. Anisotropic adhesion and friction forces were measured when sliding the top glass surface along (+y) and against (-y) the tilted direction of the flaps. Increasing the surface roughness first increased the adhesion and friction forces measured between the flaps and the rough surface due to topological matching of the two surfaces but then led to a rapid decrease in both of these forces. Our results demonstrate that the surface roughness significantly affects the performance of gecko mimetic adhesives and that different surface textures can either increase or decrease the adhesion and friction forces of the fabricated adhesives.

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Millimeter size patch behavior of gecko-inspired reversible adhesive

Cited by 5 publications

References 12 publications

Development of a Bioinspired, Self‐Adhering, and Drug‐Eluting Laryngotracheal Patch

Development of a Bioinspired, Self‐Adhering, and Drug‐Eluting Laryngotracheal Patch

Vertical Anisotropic Microfibers for a Gecko-Inspired Adhesive

Friction and Adhesion of Gecko-Inspired PDMS Flaps on Rough Surfaces

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