Abstract:A 16-year-old girl from Guinea (in the United States one year) with a history of malaria treated as a child and mild anemia, developed symptoms of headache, meningismus, malaise, upper then lower extremity weakness, diarrhea, nausea, emesis, and polydipsia resulting in multiple outside emergency department visits beginning 3 weeks before presentation to our institution. One week before her presentation to us, she was noted to have altered mental status and was admitted to an outside hospital. A lumbar puncture… Show more
“…Although a few cases of GAD-65 Ab–positive MFS have been reported (1–3), to the best of our knowledge, this is the first reported case of GAD-65 Ab–positive MFS with severe and persistent vision loss and optic disc edema. Optic disc edema in GQ-1b Ab–positive MFS has been found in a few reported cases and is usually associated with severe headaches and resolution of optic disc edema with IVIG (4,5). By contrast, our patient had only transient moderate holocephalic headache.…”
FIG. 2. Optic disc photographs after 5 days of IVIG and on the high dose of acetazolamide (A) showed Grade IV bilateral optic disc edema, which resolved after a course of steroids (B).
“…Although a few cases of GAD-65 Ab–positive MFS have been reported (1–3), to the best of our knowledge, this is the first reported case of GAD-65 Ab–positive MFS with severe and persistent vision loss and optic disc edema. Optic disc edema in GQ-1b Ab–positive MFS has been found in a few reported cases and is usually associated with severe headaches and resolution of optic disc edema with IVIG (4,5). By contrast, our patient had only transient moderate holocephalic headache.…”
FIG. 2. Optic disc photographs after 5 days of IVIG and on the high dose of acetazolamide (A) showed Grade IV bilateral optic disc edema, which resolved after a course of steroids (B).
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