Miller-fisher syndrome on the borders of guillain-barre syndrome: about one case and review of literature

Labodi, Lompo Djingri; Adrien, Maitrot; Anne, Aubertin; Muhammad, Khatib; René, Decombes; Bernard, Billaud

doi:10.15761/cmr.1000106

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…The patient presented clinically and electrophysiologically with an overlapping MFS and GBS syndrome. In the literature, several overlapping syndromes between GBS and MFS have been described [ 2 , 5 ], and cranial nerves involvement seems to be the common point between these forms [ 5 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

Is Guillain–Barre syndrome following chickenpox a parainfectious disease? A case report and literature review

Ido¹,

Guebre²,

Carama³

et al. 2023

BMC Neurol

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Background Polyradiculoneuropathy following infection with varicella zoster virus (VZV) is rare and most of the time, happens in the context of reactivation of latent VZV. We report a case of acute polyradiculoneuropathy following primary infection with VZV marked by atypical clinical features raising the hypothesis of a para-infectious disease. Case presentation We describe a 43-years-old male who developed ataxia, dysphagia, dysphonia, and oculomotor disorders (vertical binocular diplopia and bilateral ptosis) followed by quadriplegia with areflexia which occurred 4 days later. The patient had a history of varicella that occurred 10 days before the onset of these symptoms. Nerve conduction study revealed features consistent with an acute motor-sensory axonal neuropathy (AMSAN). Anti-ganglioside antibodies were negative. Based on clinical presentation and ancillary examination, we retain the Miller Fisher/Guillain-Barré overlap syndrome diagnosis. The patient was treated with high doses of methylprednisolone but the evolution of the disease was nevertheless marked by a complete recovery six weeks after onset of symptoms. Conclusion GBS following varicella is a rare but severe disease occurring most often in adults and marked by greater involvement of the cranial nerves. Its clinical features suggest that it is a para-infectious disease. Antiviral therapy has no effect on the course of the disease but its administration within the first 24 h after the onset of chickenpox in adults can prevent its occurrence.

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Section: Discussionmentioning

confidence: 99%

Is Guillain–Barre syndrome following chickenpox a parainfectious disease? A case report and literature review

Ido¹,

Guebre²,

Carama³

et al. 2023

BMC Neurol

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“…According to their clinical features, GBS and its variant MFS can be classified into different subtypes which together form a continuous spectrum of several overlapping syndromes. The involvement of cranial nerves other than the typical oculomoteur ones, seems to be more frequent in the forms of MFS-GBS overlap: facial nerve in 30 to 50%, glossopharyngeal (IX), vagus (X), large hypoglossus (XII), responsible for disorders of swallowing and dysphonia, in 13% of cases [5,6]. The nasal voice related to palate paresis has been rarely described in MFS [7,8].…”

Section: Discussionmentioning

confidence: 99%

A case of Miller fisher’s Syndrome Presenting with Dysphagia and Nasal Voice

Tamaoui¹,

Rahmani²,

Touati³

et al. 2020

Preprint

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Miller Fisher Syndrome (MFS) is a rare variant of Guillain-Barré Syndrome (GBS). It is largely a clinical diagnosis based on the classical features of ataxia, areflexia, and opthalmoplegia. Its clinical evolution is most often favorable. However, other neurological signs and symptoms may also be present. Supportive laboratory studies (positivity of antibodies, CSF albumin-cytological dissociation and nerve conduction studies) are useful especially in uncommon presentations. We report a case of a 74-year-old patient who exhibited dysphonia and difficulty to swallowing previously to the classic triad of ataxia, areflexia, and opthalmoplegia, characteristic of MFS. CSF analysis demonstrates an albumin-cytological dissociation but anti-GQ1b antibody were negative. The patient has spontaneously and completely recovered after several weeks.

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Miller-fisher syndrome on the borders of guillain-barre syndrome: about one case and review of literature

Cited by 2 publications

References 18 publications

Is Guillain–Barre syndrome following chickenpox a parainfectious disease? A case report and literature review

Is Guillain–Barre syndrome following chickenpox a parainfectious disease? A case report and literature review

A case of Miller fisher’s Syndrome Presenting with Dysphagia and Nasal Voice

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