Milk transfer of cyanide and thiocyanate: Cyanide exposure 
by lactation in goats

Soto-Blanco, Benito; Górniak, Silvana Lima

doi:10.1051/vetres:2002068

Cited by 33 publications

(15 citation statements)

References 27 publications

(28 reference statements)

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“…Similarly, Shivanoor and David (2015) observed no changes in body weight and reproductive organs weight of rats perorally treated with sodium cyanide (doses 0.64 and 1.2 mg/kg) for 90 days. It was also determined that peroral application of potassium cyanide did not influence goats' body weight after 90 days (Soto-Blanco & Górniak, 2003). According to Ibebunjo, Kamalu, and Ihemelandu (1992), peroral administration of sodium cyanide induced no differences in weights and lengths of dogs' bones (humerus, radius, ulna, femur, tibia, fibula) after 14 weeks.…”

Section: Discussionmentioning

confidence: 99%

Long‐term peroral administration of bitter apricot seeds influences cortical bone microstructure of rabbits

Kováčová¹,

Sarocka²,

Blahová³

et al. 2019

Animal Physiology Nutrition

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Apricot seeds due to the presence of cyanogenic glycoside amygdalin belong to the popular “alternative cancer cures", although anticancer effect of amygdalin remains controversial. This in vivo study points to the effect of long‐term peroral administration of bitter apricot seeds on bone microstructure of rabbits since chronic amygdalin toxicity in relation to bone parameters has not been investigated yet. Rabbits (n = 16) were randomly divided into four experimental groups of 4 animals each. Three experimental groups S1, S2 and S3 received commercial feed for rabbits mixed with crushed bitter apricot seeds at doses 60, 300 and 420 mg/kg bw during five months, respectively. The control (C) group received no apricot seeds. The long‐term consumption of apricot seeds had no impact on total body weight, femoral weight and femoral length of rabbits. Also, microcomputed tomography (3D analysis) of cortical and trabecular bone tissues did not reveal any significant impact of amygdalin toxicity on relative bone volume, BMD, cortical bone thickness, bone surface, trabecular number, thickness, and their separation. On the other hand, histological (2D) analysis demonstrated evident changes in cortical bone microstructure consistent with a decreased density of secondary osteons in the middle part of substantia compacta due to a replacement of Haversian bone tissue by plexiform bone tissue, vasoconstriction in the primary osteons' vascular canals, Haversian canals, and decreased sizes of secondary osteons in rabbits from S1, S2 and S3 groups. These negative changes are associated with different vascularization and biomechanical properties of cortical bones.

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Section: Discussionmentioning

confidence: 99%

Long‐term peroral administration of bitter apricot seeds influences cortical bone microstructure of rabbits

Kováčová¹,

Sarocka²,

Blahová³

et al. 2019

Animal Physiology Nutrition

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“…; Okolie and Osagie ; Ramirez et al . ; Soto‐Blanco and Górniak ; Moery and Pontious ; Wu et al . ).…”

Section: Introductionunclassified

Influence of brodifacoum and bromadiolone on growth of yoghurt cultures in milk

Hathurusinghe

Ibrahim

2015

Int J of Dairy Tech

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The influence of brodifacoum and bromadiolone on the growth of yoghurt culture in milk was determined. Milk samples inoculated with a commercial yoghurt culture and serially diluted rodenticides were incubated at 42°C for 6 h. The yoghurt cultures showed detectable sensitivity (significant change (P < 0.05) in pH in the medium) to brodifacoum at 0.12 mg/mL and to bromadiolone at 0.08 mg/mL. There were significant differences (P < 0.05) in the bacterial count and a-galactosidase and b-galactosidase activities in the presence of toxins in milk. The results indicate that brodifacoum and bromadiolone could inhibit the growth of yoghurt culture in milk.

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“…Cauliflower, cabbage, radishes, spinach, and tomatoes have been reported to contain on average 88, 86, 7, 5, and 2 mg/kg (wet weight) respectively of SCN Ϫ (17). Milk contains 2-10 mg/L SCN Ϫ derived from dairy cattle grazing on plants from the cruciferous family (17)(18)(19)(20)(21)(22). In some areas of the world, SCN Ϫ is added to milk as a preservative (23).…”

Section: Introductionmentioning

confidence: 99%

Relative Potencies and Additivity of Perchlorate, Thiocyanate, Nitrate, and Iodide on the Inhibition of Radioactive Iodide Uptake by the Human Sodium Iodide Symporter

Tonacchera

Pinchera

Dimida

et al. 2004

Thyroid

287

235

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The presence of perchlorate (ClO(4) (-)) in some U.S. drinking water supplies has raised concern about potential adverse thyroidal health effects, because ClO(4) (-) is known to competitively inhibit iodide uptake at the sodium iodide symporter (NIS). Humans are nutritionally and environmentally exposed to other competitive inhibitors of iodide uptake, including thiocyanate (SCN(-)) and nitrate (NO(3) (-)). The joint inhibiting effects of these three anions was studied by exposing Chinese hamster ovary cells stably expressing human NIS to varying concentrations of each anion separately, and in combination, and conducting measurements of (125)I(-) uptake. The entire data set was fit to a single Hill equation using maximum likelihood. The relative potency of ClO(4) (-) to inhibit (125)I(-) uptake at the NIS was found to be 15, 30 and 240 times that of SCN(-), I(-), and NO(3) (-) respectively on a molar concentration basis, with no evidence of synergism. These results are consistent with a common mode of action by these anions of simple competitive interaction, in which a concentration of any one of ClO(4) (-) SCN(-), and NO(3) (-), occurring either individually or as part of a mixture of the three anions, is indistinguishable from a concentration or dilution of either one of the remaining two ions in inhibiting iodine uptake at the NIS.

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Milk transfer of cyanide and thiocyanate: Cyanide exposure by lactation in goats

Cited by 33 publications

References 27 publications

Long‐term peroral administration of bitter apricot seeds influences cortical bone microstructure of rabbits

Long‐term peroral administration of bitter apricot seeds influences cortical bone microstructure of rabbits

Influence of brodifacoum and bromadiolone on growth of yoghurt cultures in milk

Relative Potencies and Additivity of Perchlorate, Thiocyanate, Nitrate, and Iodide on the Inhibition of Radioactive Iodide Uptake by the Human Sodium Iodide Symporter

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