Milk Stimulates Growth of Prostate Cancer Cells in Culture

Tate, Patricia L.; Bibb, Robert; Larcom, Lyndon L.

doi:10.1080/01635581.2011.609306

Cited by 24 publications

(27 citation statements)

References 24 publications

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“…Recent studies revealed that milk protein plays a key role in the development and modulation of prostate cancer cell proliferation [16,17,23]. Tate et al [16] reported that cow's milk stimulated the growth of prostate cancer cells (LNCaP) almost as much as digested whole milk.…”

Section: Discussionmentioning

confidence: 99%

“…Tate et al [16] reported that cow's milk stimulated the growth of prostate cancer cells (LNCaP) almost as much as digested whole milk. Like our results, neither casein nor digested milk increased the growth of breast cancer cells (MCF-7).…”

Section: Discussionmentioning

confidence: 99%

“…Several cell culture studies showed that milk protein could contribute to cancer prevention. The opposite results have appeared in recent epidemiologic studies [16,17]. The growth of prostate cancer cells was stimulated by milk protein [16,17].…”

Section: Introductionmentioning

confidence: 91%

“…The opposite results have appeared in recent epidemiologic studies [16,17]. The growth of prostate cancer cells was stimulated by milk protein [16,17]. Owing to these conflicting results, the potential role of milk protein in prostate cancer is still controversial.…”

Section: Introductionmentioning

confidence: 99%

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A Milk Protein, Casein, as a Proliferation Promoting Factor in Prostate Cancer Cells

Park

Kim

et al. 2014

World J Mens Health

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PurposeDespite most epidemiologic studies reporting that an increase in milk intake affects the growth of prostate cancer, the results of experimental studies are not consistent. In this study, we investigated the proliferation of prostate cancer cells treated with casein, the main protein in milk.Materials and MethodsProstate cancer cells (LNCaP and PC3), lung cancer cells (A459), stomach cancer cells (SNU484), breast cancer cells (MCF7), immortalized human embryonic kidney cells (HEK293), and immortalized normal prostate cells (RWPE1) were treated with either 0.1 or 1 mg/mL of α-casein and total casein extracted from bovine milk. Treatments were carried out in serum-free media for 72 hours. The proliferation of each cell line was evaluated by an 3-(4,5-Dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay.Resultsα-Casein and total casein did not affect the proliferations of RWPE1, HEK293, A459, SNU484, MCF7, HEK293, or RWPE1 cells. However, PC3 cells treated with 1 mg/mL of α-casein and casein showed increased proliferation (228% and 166%, respectively), and the proliferation of LNCaP cells was also enhanced by 134% and 142%, respectively. The proliferation mechanism of α-casein in PC3 and LNCaP cells did not appear to be related to the induction of Insulin-like growth factor-1 (IGF-1), since the level of IGF-1 did not change upon the supplementation of casein.ConclusionsThe milk protein, casein, promotes the proliferation of prostate cancer cells such as PC3 and LNCaP.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Milk Protein, Casein, as a Proliferation Promoting Factor in Prostate Cancer Cells

Park

Kim

et al. 2014

World J Mens Health

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“…Environmental factors such as exposure to ionizing radiation, inheriting certain genes such as BRCA1 and BRCA2, and, most importantly, lifestyle have been associated with an increase in the risk of breast cancer. For instance, the link between breast carcinogenesis and naturally occurring substances such as heterocyclic amines (HCAs), insulin-like growth hormone (IGF-I), animal estrogen (E2), and bovine leukaemia virus (BLV), which are ubiquitous in western and modern diets, have been substantiated with a vast body of evidence [4][5][6][7][8][9][10][11]. Nonetheless, not much has been done in updating the dietary guidelines and food policies to address the role of these substances, and similar ones, in cancer epidemic.…”

Section: Introductionmentioning

confidence: 99%

Near-Field Radar Microwave Imaging as an Add-on Modality to Mammography

Ghanbarzadeh-Dagheyan¹,

Molaei²,

Obermeier³

et al. 2017

New Perspectives in Breast Imaging

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According to global statistics, there is a high incidence of cancer in western countries; and, due to the limited resources available in most health care systems, it seems like one of the most feasible options to fight against cancer might be strict prevention policiessuch as eliminating carcinogens in people's daily lives. Nevertheless, early cancer detection and effective treatment are still necessary, and understanding their efficacy and limitations are important issues that need to be addressed in order to ultimately enhance patients' survival rate. In the case of breast cancer, some of the problems faced by conventional mammography have been addressed in the literature; they include high rate of false-positive and false-negative results, as well as the possibility of overdiagnosis. New technologies, such as digital breast tomosynthesis (DBT), have been able to improve the sensitivity and specificity by using 3D imaging. However, the low contrast (1%) existing between tumors and healthy fibroglandular tissue at X-ray frequencies has been identified as one of the main causes of misdiagnosis in both conventional 2D mammography and DBT. Near-field radar imaging (NRI) provides a unique opportunity to overcome this problem, since the contrast existing between the aforementioned tissues is intrinsically higher (10%) at microwave frequencies. Moreover, the low resolution and highly complex scattering patterns of microwave systems can be enhanced by using prior information from other modalities, such as the DBT. Therefore, a multimodal DBT/NRI imaging system is proposed to exploit their individual strengths while minimizing their weaknesses. In this work, the foundation of this idea is reviewed, and a preliminary design and experimental validation of the NRI system, used as a DBT complement, is introduced.

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Dietary Carcinogens and DNA Adducts in Prostate Cancer

Bellamri

Turesky

2019

Advances in Experimental Medicine and Biology

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Prostate cancer (PC) is the most commonly diagnosed non-cutaneous cancer and the second leading cause of cancer-related to death in men. The major risk factors for PC are age, family history, and African American ethnicity. Epidemiological studies have reported large geographical variations in PC incidence and mortality, and thus lifestyle and dietary factors influence PC risk. High fat diet, dairy products, alcohol and red meats, are considered as risk factors for PC. This book chapter provides a comprehensive, literature-based review on dietary factors and their molecular mechanisms of prostate carcinogenesis. A large portion of our knowledge is based on epidemiological studies where dietary factors such as cancer promoting agents, including high-fat, dairy products, alcohol, and cancer-initiating genotoxicants formed in cooked meats have been evaluated for PC risk. However, the precise mechanisms in the etiology of PC development remain uncertain. Additional animal and human cell-based studies are required to further our understandings of risk factors involved in PC etiology. Specific biomarkers of chemical exposures and DNA damage in the prostate can provide evidence of cancer-causing agents in the prostate. Collectively, these studies can improve public health research, nutritional education and chemoprevention strategies

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Milk Stimulates Growth of Prostate Cancer Cells in Culture

Cited by 24 publications

References 24 publications

A Milk Protein, Casein, as a Proliferation Promoting Factor in Prostate Cancer Cells

A Milk Protein, Casein, as a Proliferation Promoting Factor in Prostate Cancer Cells

Near-Field Radar Microwave Imaging as an Add-on Modality to Mammography

Dietary Carcinogens and DNA Adducts in Prostate Cancer

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