Milk polar lipids favorably alter circulating and intestinal ceramide and sphingomyelin species in postmenopausal women

Barz, Mélanie Le; Vors, Cécile; Combe, Emmanuel; Joumard‐Cubizolles, Laurie; Lecomte, Manon; Joffre, Florent; Trauchessec, Michèle; Pesenti, Sandra; Loizon, Emmanuelle; Breyton, Anne-Esther; Meugnier, Emmanuelle; Bertrand, Karène; Drai, Jocelyne; Robert, Chloé; Durand, Annie; Cuerq, Charlotte; Gaborit, P.; Leconte, Nadine; Bernalier-Donadille, Annick; Cotte, Eddy; Laville, Martine; Lambert‐Porcheron, Stéphanie; Ouchchane, Lemlih; Vidal, Hubert; Malpuech-Brugère, Corinne; Cheillan, David; Michalski, Marie‐Caroline

doi:10.1172/jci.insight.146161

Cited by 18 publications

(20 citation statements)

References 61 publications

(105 reference statements)

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“…However, concerning the relationship between sphingolipids and cardiovascular disease, increased circulating ceramide levels are associated with a variety of metabolic and cardiovascular pathologies. − Thus, specific circulating ceramides can be used as biological predictors and markers of cardiovascular disease. However, unlike endogenous sphingolipids, dietary sphingolipids attenuated the development of atherosclerosis, rather than promoting cardiovascular disease, in animal studies. − Furthermore, supplementation with milk polar lipid enriched cream cheese (containing sphingomyelin and ceramide) decreased the levels of atherogenic sphingomyelin (C16:1 and C18:1) and ceramide (C24:1) species associated with the improvement of cardiovascular risk markers in a human trial …”

Section: Beneficial Effect Of Dietary Sphingolipids In Disease Preven...mentioning

confidence: 99%

“…122−124 Furthermore, supplementation with milk polar lipid enriched cream cheese (containing sphingomyelin and ceramide) decreased the levels of atherogenic sphingomyelin (C16:1 and C18:1) and ceramide (C24:1) species associated with the improvement of cardiovascular risk markers in a human trial. 125 Several studies have indicated the suppressive effects of dietary sphingolipids derived from foodstuffs on colon cancer in chemically induced rodent models, such as 1,2-dimethylhydrazine and azoxymethane, as well as in inheritance models. 6 Sphingolipids are not as easily digested in the small intestine as glycerolipids.…”

Section: Beneficial Effect Of Dietary Sphingolipids In Disease Preven...mentioning

confidence: 99%

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Sphingolipids as Functional Food Components: Benefits in Skin Improvement and Disease Prevention

Sugawara

2022

J. Agric. Food Chem.

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Sphingolipids are ubiquitous components in eukaryotic organisms and have attracted attention as physiologically functional lipids. Sphingolipids with diverse structures are present in foodstuffs as these structures depend on the biological species they are derived from, such as mammals, plants, and fungi. The physiological functions of dietary sphingolipids, especially those that improve skin barrier function, have recently been noted. In addition, the roles of dietary sphingolipids in the prevention of diseases, including cancer and metabolic syndrome, have been studied. However, the mechanisms underlying the health-improving effects of dietary sphingolipids, especially their metabolic fates, have not been elucidated. Here, we review dietary sphingolipids, including their chemical structures and contents in foodstuff; digestion, intestinal absorption, and metabolism; and nutraceutical functions, based on the available evidence and hypotheses. Further research is warranted to clearly define how dietary sphingolipids can influence human health.

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Section: Beneficial Effect Of Dietary Sphingolipids In Disease Preven...mentioning

confidence: 99%

Section: Beneficial Effect Of Dietary Sphingolipids In Disease Preven...mentioning

confidence: 99%

Sphingolipids as Functional Food Components: Benefits in Skin Improvement and Disease Prevention

Sugawara

2022

J. Agric. Food Chem.

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“…A complementary study also showed that the ingestion of MPLs by patients with ileostomy decreased cholesterol absorption, 11 a finding that agrees with those indicating dietary MSM is incompletely absorbed and inhibits cholesterol absorption. 113 Of particular interest are the secondary analyses performed with obese postmenopausal women that showed MPL decreased atherogenic species of SM (C16 + 18 SM) and ceramide (C24:1) species in the serum, 151 and that C16 + 18 SM was correlated with favorable changes in total cholesterol, LDL-C, and ApoB levels. Despite high-dose supplementation of SM from MPLs, SM and ceramide concentrations in intestine-derived chylomicrons were decreased, whereas their levels in fecal contents increased.…”

Section: Cardiometabolic Benefits Of Mfgm-derived Phospholipidsmentioning

confidence: 99%

Cardiometabolic health benefits of dairy-milk polar lipids

et al. 2021

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Low-quality dietary patterns impair cardiometabolic health by increasing the risk of obesity-related disorders. Cardiometabolic risk relative to dairy-food consumption continues to be a controversial topic, due to recommendations that endorse low-fat and nonfat dairy foods over full-fat varieties despite accumulated evidence that does not strongly support these recommendations. Controlled human studies and mechanistic preclinical investigations support that full-fat dairy foods decrease cardiometabolic risk by promoting gut health, reducing inflammation, and managing dyslipidemia. These gut- and systemic-level cardiometabolic benefits are attributed, at least in part, to milk polar lipids (MPLs) derived from the phospholipid- and sphingolipid-rich milk fat globule membrane that is of higher abundance in full-fat dairy milk. The controversy surrounding full-fat dairy food consumption is discussed in this review relative to cardiometabolic health and MPL bioactivities that alleviate dyslipidemia, shift gut microbiota composition, and reduce inflammation. This summary, therefore, is expected to advance the understanding of full-fat dairy foods through their MPLs and the need for translational research to establish evidence-based dietary recommendations.

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“…In ileostomy patients feeding up to 200-mg milk SM in a test meal generated only modest increases of some ceramide and SM species in the content ( 82 ). A recent study on post-menopausal women who ingested cream cheese with 3- or 5-g milk polar lipids for 4 weeks found that the ceramide content in feces and ileostomy increased more than the content of milk SM species ( 83 ). The conclusion from these studies is that SM is extensively digested even with an MFGM lipid load, whereas ceramide digestion is more incomplete.…”

Section: The Digestion Of Mfgmmentioning

confidence: 99%

“…In ileostomy subjects, both cholesterol and SM were increased in the ileal fraction after intake of milk PL. In a second study, it was concluded that the 4-week milk PL supplementation (both 3 and 5 g) decreased post-prandial total cholesterol, apoB/apoA1 ratio, total chylomicron SM and ceramide, and also the levels of potentially atherogenic SM and ceramide species ( 83 ).…”

Section: Effects Of Dairy Polar Lipids On Cholesterol Absorptionmentioning

confidence: 99%

Digestion and Absorption of Milk Phospholipids in Newborns and Adults

2021

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Milk polar lipids provide choline, ethanolamine, and polyunsaturated fatty acids, which are needed for the growth and plasticity of the tissues in a suckling child. They may also inhibit cholesterol absorption by interacting with cholesterol during micelle formation. They may also have beneficial luminal, mucosal, and metabolic effects in both the neonate and the adult. The milk fat globule membrane contains large proportions of sphingomyelin (SM), phosphatidylcholine (PC), and phosphatidylethanolamine (PE), and some phosphatidylserine (PS), phosphatidylinositol (PI), and glycosphingolipids. Large-scale technical procedures are available for the enrichment of milk fat globule membrane (MFGM) in milk replacement formulations and food additives. Pancreatic phospholipase A2 (PLA2) and mucosal phospholipase B digest glycero-phospholipids in the adult. In the neonate, where these enzymes may be poorly expressed, pancreatic lipase-related protein 2 probably has a more important role. Mucosal alkaline SM-ase and ceramidase catalyze the digestion of SM in both the neonate and the adult. In the mucosa, the sphingosine is converted into sphingosine-1-phosphate, which is both an intermediate in the conversion to palmitic acid and a signaling molecule. This reaction sequence also generates ethanolamine. Here, we summarize the pathways by which digestion and absorption may be linked to the biological effects of milk polar lipids. In addition to the inhibition of cholesterol absorption and the generation of lipid signals in the gut, the utilization of absorbed choline and ethanolamine for mucosal and hepatic phospholipid synthesis and the acylation of absorbed lyso-PC with polyunsaturated fatty acids to chylomicron and mucosal phospholipids are important.

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Milk polar lipids favorably alter circulating and intestinal ceramide and sphingomyelin species in postmenopausal women

Cited by 18 publications

References 61 publications

Sphingolipids as Functional Food Components: Benefits in Skin Improvement and Disease Prevention

Sphingolipids as Functional Food Components: Benefits in Skin Improvement and Disease Prevention

Cardiometabolic health benefits of dairy-milk polar lipids

Digestion and Absorption of Milk Phospholipids in Newborns and Adults

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