Milk Lipids and Neonatal Fat Digestion: Relationship between Fatty Acid Composition, Endogenous and Exogenous Digestive Enzymes and Digestion of Milk Fat

Hamosh, Margit; Iverson, Sara J.; Kirk, Charlotte L.; Hamosh, Paul

doi:10.1159/000423556

Cited by 21 publications

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“…The source of fat and digestion of fat 57 have an interesting relationship that can have other important roles in early development. Specifically, hydrolysis of milk fat, but not other lipids, inhibits parasites.…”

Section: Discussionmentioning

confidence: 99%

Activities of gastric, pancreatic, and intestinal brush-border membrane enzymes during postnatal development of dogs

Buddington

Elnif

Malo

et al. 2003

ajvr

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Secretions in the gastrointestinal tract proximal to the duodenum, enzymes in milk, and other digestive mechanisms compensate for low luminal activities of pancreatic enzymes during the perinatal period. Postnatal changes in digestive secretions influence nutrient availability, concentrations of signaling molecules, and activity of antimicrobial compounds that inhibit pathogens. Matching sources of nutrients to digestive abilities will improve the health of dogs during development.

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Section: Discussionmentioning

confidence: 99%

Activities of gastric, pancreatic, and intestinal brush-border membrane enzymes during postnatal development of dogs

Buddington

Elnif

Malo

et al. 2003

ajvr

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“…Substrate selectivity is also an important function of gastric lipase. Gastric lipase has high specificity to sn-3 position of the triglycerides (Hamosh, 1996;Hamosh, Iverson, Kirk, and Hamosh, 1994). As a result, long-chain polyunsaturated fatty acids in mother milk and short to medium chain fatty acids in bovine milk are efficiently released in the infant stomach because they are primarily settled at sn-3 position (Hamosh, 2006).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

A comprehensive review on in vitro digestion of infant formula

Nguyen

Bhandari

Cichero

et al. 2015

Food Research International

102

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Although mothers' milk is the best food for babies, infant formula has become an alternative when breastfeeding is not possible or inadequate for babies. To design a proper formula for babies, understanding digestibility of macronutrients and their bio-accessibility in the gastrointestinal tract is essential. In vivo gastrointestinal studies on human infants are restricted by ethical constraint, cost issues, and intensive resource. However, in vitro models offer many advantages with low cost, easy sampling accessibility and no ethical issues. This article aims at reviewing the main aspects of the infant physiological gastrointestinal tract and providing an insight on recent in vitro research on infant formula.

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“…In the ferret, fat digestion during this period is markedly aided by the very high activity of milk bile salt‐dependent lipase(24,25), an enzyme identical to pancreatic carboxylester lipase (34). However, as previously reported for colipase‐dependent lipase (35,36) and recently for milk bile salt‐dependent lipase(37,38), milk triglyceride within milk fat globules is inaccessible to these digestive enzymes before partial lipolysis. This crucial step in the digestion of milk fat is carried out by gastric lipase, a highly hydrophobic enzyme (1,4) able to access the triglyceride within the core of milk fat globules(14,39).…”

Section: Discussionmentioning

confidence: 52%

Gastric Lipase and Pepsin Activities in the Developing Ferret: Nonparallel Development of the Two Gastric Digestive Enzymes

Hamosh,

Henderson,

Hamosh

1998

J. pediatr. gastroenterol. nutr.

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Background:Gastric lipase has an important compensatory function in neonatal fat digestion. The activity level of pepsin and its role in protein digestion is less well understood. We have, therefore, studied the ontogeny of lipase and pepsin in the ferret, a species with a neonatal fat digestion pattern similar to that of humans.Methods:Gastric lipase and pepsin activities were quantified from the late fetal period throughout lactation, and were compared with those of the adult.Results:The data show earlier ontogeny and much more rapid rise of lipase activity than of pepsin. Lipase activity was present during the last week of fetal development, whereas pepsin was detected only postnatally. Lipase activity was 72.8% ± 14.2% and 153% ± 9.95% and pepsin activity was 11.6%± 1.3% and 30.1% ± 1.3% of the adult level at 2 and 4 wk of age, respectively.Conclusions:We conclude that lipase activity develops early and exceeds adult activity during the suckling period, when fat intake is very high. The low pepsin activity and high postprandial pH probably limit gastric proteolysis, thereby contributing to the structural and functional stability of milk proteins, many with protective or bioactive function in the gastrointestinal tract of the newborn.

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Milk Lipids and Neonatal Fat Digestion: Relationship between Fatty Acid Composition, Endogenous and Exogenous Digestive Enzymes and Digestion of Milk Fat

Cited by 21 publications

References 0 publications

Activities of gastric, pancreatic, and intestinal brush-border membrane enzymes during postnatal development of dogs

Activities of gastric, pancreatic, and intestinal brush-border membrane enzymes during postnatal development of dogs

A comprehensive review on in vitro digestion of infant formula

Gastric Lipase and Pepsin Activities in the Developing Ferret: Nonparallel Development of the Two Gastric Digestive Enzymes

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