Milk fermented with Lactococcus lactis KLDS4.0325 alleviates folate status in deficient mice

Abstract

This study proved that milk fermented with L. lactis KLDS4.0325 can alleviate the folate status in deficient mice by animal experiment.

Effect of folA gene in human breast milk-derived Limosilactobacillus reuteri on its folate biosynthesis

“…Folate produced by microorganisms has no side effects in the human body ( Jiao et al, 2020 ), but the resulting folate content is relatively low. However, microbial molecular breeding can solve the above problems by transforming strains for specific production purposes to obtain high-yield strains, thereby meeting specific needs.…”

The regulation function of intestinal microbiota by folate‐producing Lactiplantibacillus plantarumLZ227

“…However, chemically synthesized folic acid and natural folate have different metabolic pathways and mechanisms of action in the human body and have certain side effects. 7 Studies have found that lactic acid bacteria (LABs) in intestinal microorganisms can metabolize and produce vitamins such as folic acid, which is one of the main sources of host vitamins. 8 At the same time, folic acid synthesized by LABs can reduce the side effects caused by the chemical folic acid and has a good safety profile.…”

“…Studies have found that folate-producing L. lactis not only effectively increases plasma folate concentrations in mice, but also reduces blood homocysteine levels. 7 Though some LABs cannot synthesize folic acid intact, it has been found that the addition of p-aminobenzoic acid to the medium can greatly increase folate production. 14 In recent years, people often increase their intake of natural folate by supplementing folateproducing LABs or fermented products to prevent and treat chronic diseases in the human body.…”

“…However, humans and other mammals are unable to synthesize folic acid by themselves but can absorb exogenous folic acid through the intestine. However, chemically synthesized folic acid and natural folate have different metabolic pathways and mechanisms of action in the human body and have certain side effects 7 . Studies have found that lactic acid bacteria (LABs) in intestinal microorganisms can metabolize and produce vitamins such as folic acid, which is one of the main sources of host vitamins 8 .…”

“…used the mouse folate‐deficiency model to study the role of fermented milk with L. lactis KLDS4.0325 (folate producer) in improving folate deficiency. Studies have found that folate‐producing L. lactis not only effectively increases plasma folate concentrations in mice, but also reduces blood homocysteine levels 7 . Though some LABs cannot synthesize folic acid intact, it has been found that the addition of p ‐aminobenzoic acid to the medium can greatly increase folate production 14 .…”