Milk Fat Globule Membrane Enhances Colonic–Mucus‐Barrier Function in a Rat Model of Short‐Bowel Syndrome

Yu, Zhongqi; Li, Ying; Niu, Yang; Tang, Qingya; Wu, Jiang

doi:10.1002/jpen.1956

Cited by 14 publications

(12 citation statements)

References 38 publications

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“…The beneficial role of MFGM has already been explored in animals and adults. Studies on rodent models have proven the impact of MFGM on infection, inflammation, brain composition, and gut barrier integrity, as well as intestinal development [30][31][32][33][34]. Interestingly, pups fed control formula demonstrated delayed intestinal growth, while the MFGM supplementation normalized intestinal crypt depths, epithelial cell proliferation, make-up of intestinal epithelial cell subsets, and resembled the make-up of intestinal microbes of mother's milk-fed rats at the phylum level [34].…”

Section: Discussionmentioning

confidence: 99%

Milk Fat Globule Membrane Supplementation in Children: Systematic Review with Meta-Analysis

et al. 2021

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(1) Background: Milk fat globule membrane (MFGM), composing fat droplets responsible for lipid transport in breast milk, has been shown to possess immunological and antimicrobial effects. Standard formulas (SF) are devoid of MFGMs during the production process. The study’s aim was to evaluate the safety and benefits of MFGMs supplementation in children. (2) Methods: We searched four databases for randomized controlled trials evaluating the supplementation of MFGMs in children. Growth parameters were chosen as the primary outcome. (3) Results: Twenty-four publications of seventeen studies were included. Meta-analyses assessing the primary outcomes at the age of 4 months included four studies (814 children) comparing the MFGM-supplemented formulas and SF, and two trials (549 children) comparing the MFGM-supplemented formulas and breastfeeding. The primary outcomes were non-inferior in all the experimental MFGM formulas compared to SF, or even represented more similar results to breastfed infants. The promising effects, including a lower incidence of acute otitis media and improved cognitive development, cannot be firmly confirmed due to the small amount of existing evidence. No significant adverse effects were reported in any of the assessed products. (4) Conclusions: The available data signaled beneficial effects and a good safety profile, requiring future research with well-designed trials.

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Section: Discussionmentioning

confidence: 99%

Milk Fat Globule Membrane Supplementation in Children: Systematic Review with Meta-Analysis

et al. 2021

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“…Broad‐spectrum antibiotics successfully ameliorated liver inflammation and steatosis in SBS animals, 142 but reduced gut adaption 142,143 . Probiotics and prebiotics (Table 2) improved gut adaption and gut barrier function in SBS animals and patients in most studies 144‐153 with several showed no significant improvement 154,155 ; but many probiotics used in these studies encode bsh genes, such as Lactobacillus johnsonii and Bifidobacterium breve . Probiotics with high BSH activity increase bile acid deconjugation, decrease bile acid and lipid absorption, downregulate FXR signals and increase hepatic synthesis of bile acids and lipids 156,157 ; in IF, these effects could aggravate bile acid and lipid dysmetabolism and cause liver cholestasis and steatosis.…”

Section: The Ba‐gm Axis and Clinical Management Of Ifaldmentioning

confidence: 99%

Review article: insights into the bile acid‐gut microbiota axis in intestinal failure‐associated liver disease—redefining the treatment approach

Wang

Zhou

Yao

et al. 2021

Aliment Pharmacol Ther

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Summary Background Intestinal failure‐associated liver disease (IFALD) increases mortality of patients with intestinal failure (IF), but lacks effective prevention or treatment approaches. Bile acids, gut microbiota and the host have close and complex interactions, which play a central role in modulating host immune and metabolic homeostasis. Increasing evidence suggests that derangement of the bile acid‐gut microbiota (BA‐GM) axis contributes to the development of IFALD. Aims To review the BA‐GM axis in the pathogenesis and clinical applications of IFALD, and to explore future directions for effective disease management. Methods We conducted a literature search on bile acid and gut microbiota in IF and liver diseases. Results The BA‐GM axis demonstrates a unique IF signature manifesting as an increase in primary‐to‐secondary bile acids ratio, disturbed enterohepatic circulation, blunted bile acid signalling pathways, gut microbial dysbiosis, and altered microbial metabolic outputs. Bile acids and gut microbiota shape the compositional and functional alterations of each other in IF; collaboratively, they promote immune dysfunction and metabolic aberration in the liver. Diagnostic markers and treatments targeting the BA‐GM axis showed promising potential in the management of IFALD. Conclusions Bile acids and gut microbiota play a central role in the development of IFALD and make attractive biomarkers as well as therapeutic targets. A multitarget, individualised therapy aiming at different parts of the BA‐GM axis may provide optimal clinical benefits and requires future investigation.

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“…The MFGM enhanced the gut barrier function and lowered the intestinal permeability in a rat model of short bowel syndrome ( Yu et al, 2021 ). Regulation of the NLRP6 inflammasome pathway contributed to the improvement of gut dysbiosis.…”

Section: The Role Of Milk Fat Globule Membrane (Mfgm) In Infant Nutri...mentioning

confidence: 99%

Roles of Milk Fat Globule Membrane on Fat Digestion and Infant Nutrition

Chai¹,

Oh²,

Imm³

2022

Food Sci Anim Resour

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Milk fats are present as globules emulsified in the aqueous phase of milk and stabilized by a delicate membrane architecture called the milk fat globule membrane (MFGM). The unique structure and composition of the MFGM play an important role in fat digestion and the metabolic programming of neonates. The objective of this review is to compare the structure, composition, and physicochemical characteristics of fat globules in human milk, bovine milk, and infant formula. It provides an overview of the fat digestion process and enzymes in healthy infants, and describes the possible roles of the MFGM in association with factors affecting fat digestion. Lastly, the health benefits of the MFGM on infant nutrition and future perspectives are discussed with a focus on brain development, metabolic response, and gut health.

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Milk Fat Globule Membrane Enhances Colonic–Mucus‐Barrier Function in a Rat Model of Short‐Bowel Syndrome

Cited by 14 publications

References 38 publications

Milk Fat Globule Membrane Supplementation in Children: Systematic Review with Meta-Analysis

Milk Fat Globule Membrane Supplementation in Children: Systematic Review with Meta-Analysis

Review article: insights into the bile acid‐gut microbiota axis in intestinal failure‐associated liver disease—redefining the treatment approach

Roles of Milk Fat Globule Membrane on Fat Digestion and Infant Nutrition

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