Milk and Egg Are Risk Factors for Adverse Effects of Capecitabine-Based Chemotherapy in Chinese Colorectal Cancer Patients

Abstract

Background: Chemotherapy-induced adverse effects (CIAEs) remain a challenging problem due to their high incidences and negative impacts on treatment in Chinese colorectal cancer (CRC) patients. We aimed to identify risk factors and predictive markers for CIAEs using food/nutrition data in CRC patients receiving post-operative capecitabine-based chemotherapy. Methods: Food/nutrition data from 130 Chinese CRC patients were analyzed. Univariate and multivariate analyses were used to identify CIAE-related food/nutrition factors. Prediction models were constructed based on the combination of these factors. The area under the receiver operating characteristic curve (AUROC) was used to evaluate the discrimination ability of models. Results: A total of 20 food/nutrition factors associated with CIAEs were identified in the univariate analysis after adjustments for total energy and potential confounding factors. Based on multivariate analysis, we found that, among these factors, dessert, eggs, poultry, and milk were associated with several CIAEs. Most importantly, poultry was an overall protective factor; milk and egg were risk factors for hand-foot syndrome (HFS) and bone marrow suppression (BMS), respectively. Developed multivariate models in predicting grade 1 to 3 CIAEs and grade 2/3 CIAEs both had good discrimination (AUROC values from 0.671 to 0.778, 0.750 to 0.946 respectively), which had potential clinical application value in the early prediction of CIAEs, especially for more severe CIAEs. Conclusions: Our findings suggest that patients with high milk and egg intakes should be clinically instructed to control their corresponding dietary intake to reduce the likelihood of developing HFS and BMS during capecitabine-based chemotherapy, respectively. Trial registration: ClinicalTrials.gov Identifier: NCT03030508.

Lipidomic Comparisons of Whole Cream Buttermilk Whey and Cheese Whey Cream Buttermilk of Caprine Milk

“…A previous study showed that a person with a high SM (d40:2) level had a lower risk of getting chronic kidney disease . Similarly, a study has indicated that nut consumption may be beneficial for colorectal cancer patients and is positively correlated with SM (d40:2) levels in plasma . However, it remains unclear whether direct intake of SM (d40:2) has any beneficial effects on human kidney or gut health, and further investigation is necessary.…”

“…59 Similarly, a study has indicated that nut consumption may be beneficial for colorectal cancer patients and is positively correlated with SM (d40:2) levels in plasma. 60 However, it remains unclear whether direct intake of SM (d40:2) has any beneficial effects on human kidney or gut health, and further investigation is necessary. The overlap between significantly different lipid species in each comparison group is shown using a Venn diagram (Figure S5a).…”

A Systematic Review of Clinical Validated and Potential miRNA Markers Related to the Efficacy of Fluoropyrimidine Drugs

“…Last but not least, screening miRNAs from normal tissues other than tumors may provide more informative clues. Accumulating evidence suggests that the efficacy and safety of chemotherapy are not solely dependent on drug metabolism but also on the overall physiological functions [44,[48][49][50][51][52][53]. Individual differences in cell maintenance, proliferation, and immune function also influence the response to chemotherapy.…”