Milk and dairy products in cancer prevention: focus on bovine lactoferrin

Tsuda, Hiroyuki; Sekine, Kazunori; Ushida, Yoshihiko; Kuhara, Tetsuya; Takasuka, Nobuo; Iigo, Masaaki; Han, Beom Seok; Moore, Malcolm A

doi:10.1016/s1383-5742(00)00040-5

Cited by 75 publications

(47 citation statements)

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“…Calcium in milk is highly bioavailable, which may make milk appear to be associated with CRC risk independent of total calcium intake. 53 Alternatively, the protective effects of dairy products may be due to other components, such as conjugated linoleic acid and lactoferrin, which inhibit colonic carcinogenesis in animal models, 55,56 or the milk protein casein, which has been reported to have antimutagenic activity on the digestive tract. 57 Randomized trials of calcium supplementation indicate a modest but significant protective effect against CRA recurrence (pooled RR from 3 trials combined 0.80, 95%CI: 0.68-0.93).…”

Section: Discussionmentioning

confidence: 99%

Dairy products, polymorphisms in the vitamin D receptor gene and colorectal adenoma recurrence

Muir

Liu

Logan

et al. 2008

Intl Journal of Cancer

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Vitamin D receptor (VDR) activation inhibits proliferation and angiogenesis in the colorectal epithelium, and inhibits metastasis of colorectal tumors. Polymorphisms in the VDR gene alter receptor cellular levels and functioning, and may confer altered susceptibility to colorectal neoplasia. We aimed to investigate the influence of VDR polymorphisms and dietary factors impacting on vitamin D metabolism on colorectal adenoma (CRA) recurrence. Data on dietary intakes of calcium, vitamin D and dairy products were collected from 853 participants in the United Kingdom Colorectal Adenoma Prevention trial, a randomized trial of aspirin and folate for CRA recurrence prevention. The VDR Cdx2, FokI, BsmI, ApaI and TaqI polymorphisms were genotyped in 546 participants with available DNA, and gene-diet interaction analyses performed in 480. Dairy product intake was inversely related to CRA recurrence risk independent of calcium and vitamin D [relative risk (RR) 5 0.64; 95% confidence intervals (CIs): 0.47-0.88, for subjects in the highest compared to lowest intake tertile, p trend 5 0.005]. Milk accounted for 60% of dairy product intake, and on analysis of milk and nonmilk dairy products separately recurrence risk in individuals in the highest tertile of milk intake was half that of lowest tertile individuals (RR 5 0.52; 95% CI: 0.38-0.72, p trend 5 3.2 3 10 25 ), whereas nonmilk dairy products did not influence recurrence. VDR polymorphism genotypes and haplotypes did not directly alter recurrence risk, but the reduction in risk associated with high dairy product intake was confined to individuals with ApaI aA/AA genotype (p interaction 5 0.02). These findings indicate dairy products, and in particular milk, have chemopreventive activity against CRA recurrence. ' 2008 Wiley-Liss, Inc.Key words: colorectal adenoma recurrence; dairy products; VDR; polymorphism Colorectal cancer (CRC) is the third commonest cancer worldwide after lung and breast cancer, and two-thirds of CRC occurs in developed countries. 1 Up to 90% of CRCs develop from colorectal adenomas (CRAs) and colonoscopic removal of CRA reduces the incidence of CRC. 2,3 In some individuals, the recurrence rate for CRA is as high as 40-50% after 3 years, 4 CRA recurrence is a surrogate marker for CRC risk and prevention of CRA recurrence is a useful endpoint for evaluating chemopreventive agents. 5 Activation of vitamin D receptors (VDRs) present in many cell types, including colorectal epithelial cells, can inhibit proliferation, angiogenesis and invasiveness, and studies in animal models indicate that vitamin D supplementation can lower the incidence and metastatic potential of intestinal tumors. 6-9 Ecological studies correlating sunlight exposure with cancer incidence provided the first evidence that vitamin D levels are inversely related to CRC development in humans. 10 Subsequent epidemiological studies have reported lower risks of CRA and CRC in individuals with high intakes and circulating levels of vitamin D. 11-14 Vitamin D plays a crucial role in calcium me...

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Section: Discussionmentioning

confidence: 99%

Dairy products, polymorphisms in the vitamin D receptor gene and colorectal adenoma recurrence

Muir

Liu

Logan

et al. 2008

Intl Journal of Cancer

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“…However, the knowledge of both SCS and LTF seems to slightly improve the mastitis prediction. Moreover, the knowledge of LTF content in milk is also important to characterize the nutritional quality of milk (Tsuda et al, 2000). As many milk recording organizations begin to think about the possibility of retaining the spectral information, the prediction of LTF will be as easily available as the SCS data and could improve the detection of mastitis or the efficacy of breeding programs that aim to improve the mastitis resistance of dairy cows.…”

Section: Mastitis Indicatormentioning

confidence: 99%

“…Indeed, high LTF concentration in milk (2.3 g/l of milk) compared with the expected normal level (0.1 to 0.4 g/l of milk) produced by a specific cow may indicate clinical or subclinical mastitis (Kutila et al, 2004). Moreover, naturally increasing the content of LTF in milk through genetic selection could also have beneficial effects on human health (Tsuda et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Mid-infrared prediction of lactoferrin content in bovine milk: potential indicator of mastitis

Soyeurt

Bastin

Colinet

et al. 2012

Animal

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Lactoferrin (LTF) is a milk glycoprotein favorably associated with the immune system of dairy cows. Somatic cell count is often used as an indicator of mastitis in dairy cows, but knowledge on the milk LTF content could aid in mastitis detection. An inexpensive, rapid and robust method to predict milk LTF is required. The aim of this study was to develop an equation to quantify the LTF content in bovine milk using mid-infrared (MIR) spectrometry. LTF was quantified by enzyme-linked immunosorbent assay (ELISA), and all milk samples were analyzed by MIR. After discarding samples with a coefficient of variation between 2 ELISA measurements of more than 5% and the spectral outliers, the calibration set consisted of 2499 samples from Belgium (n 5 110), Ireland (n 5 1658) and Scotland (n 5 731). Six statistical methods were evaluated to develop the LTF equation. The best method yielded a cross-validation coefficient of determination for LTF of 0.71 and a cross-validation standard error of 50.55 mg/l of milk. An external validation was undertaken using an additional dataset containing 274 Walloon samples. The validation coefficient of determination was 0.60. To assess the usefulness of the MIR predicted LTF, four logistic regressions using somatic cell score (SCS) and MIR LTF were developed to predict the presence of mastitis. The dataset used to build the logistic regressions consisted of 275 mastitis records and 13 507 MIR data collected in 18 Walloon herds. The LTF and the interaction SCS 3 LTF effects were significant (P , 0.001 and P 5 0.02, respectively). When only the predicted LTF was included in the model, the prediction of the presence of mastitis was not accurate despite a moderate correlation between SCS and LTF (r 5 0.54). The specificity and the sensitivity of models were assessed using Walloon data (i.e. internal validation) and data collected from a research herd at the University of Wisconsin -Madison (i.e. 5886 Wisconsin MIR records related to 93 mastistis events -external validation). Model specificity was better when LTF was included in the regression along with SCS when compared with SCS alone. Correct classification of non-mastitis records was 95.44% and 92.05% from Wisconsin and Walloon data, respectively. The same conclusion was formulated from the Hosmer and Lemeshow test. In conclusion, this study confirms the possibility to quantify an LTF indicator from milk MIR spectra. It suggests the usefulness of this indicator associated to SCS to detect the presence of mastitis. Moreover, the knowledge of milk LTF could also improve the milk nutritional quality.

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“…Vitamin D 3 may reduce the risk of prostate cancer. Calcium from milk and dairy products may have protective properties against colon cancer, while bovine lactoferrin from whey may inhibit colon carcinogenesis (Tsuda et al, 2000;Aune et al, 2011). …”

Section: Milk and Dairy Productsmentioning

confidence: 99%