Milk and dairy product consumption in patients with inflammatory bowel disease: Helpful or harmful to bone mineral density?

Krela‐Kaźmierczak, Iwona; Michalak, Michał; Szymczak-Tomczak, Aleksandra; Czarnywojtek, Agata; Wawrzyniak, Anna; Łykowska‐Szuber, Liliana; Stawczyk‐Eder, Kamila; Dobrowolska, Agnieszka; Eder, Piotr

doi:10.1016/j.nut.2020.110830

Cited by 8 publications

(9 citation statements)

References 46 publications

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“…Conversely, a recent metaanalysis concluded that milk and dairy intake might present beneficial effects on serum concentrations of inflammation markers such as interleukin-6, tumour necrosis factor α, C-reactive protein, or Methyl-accepting chemotaxis proteins, although the studies in this analysis were carried out in adults without IBD (Moosavian et al, 2020). Furthermore, limiting the intake of milk and dairy products increases the risk of osteoporosis, which, as shown in several studies, is higher in people with IBD than in general population (Bernstein et al, 2019;Krela-Kaźmierczak et al, 2020). Earlier results comparing the consumption of milk and dairy products were highly inconsistent, thus further studies should compare the effects of standard and lactose-reduced, as well as lactose-free milk consumption on inflammation markers and GI symptoms in IBD patients.…”

Section: Discussionmentioning

confidence: 93%

Assessment of dietary habits in inflammatory bowel disease patients: A cross‐sectional study from Poland

et al. 2021

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Inflammatory bowel disease (IBD) has a negative impact on patients' quality of life and affects their dietary habits. In this cross-sectional study, we focused on the overall variety of food products consumed by IBD patients compared to a group of age-and sex-matched controls; we also investigated the self-reported, most frequently consumed and most avoided foods in relation to anticipated aggravation of IBD symptoms. We recruited 73 IBD patients from Lodz, Poland (56% with Crohn's disease [CD], 44% with ulcerative colitis [UC]); average duration of IBD 118 ± 78 months and 103 healthy volunteers aged 13-59 years, of whom 52 (72% female, 28% male) and 76 (65% female and 35% male), respectively, were enrolled for further analysis. Using a 186-item food frequency questionnaire, we found that the overall reported frequency of food products consumed was lower in IBD patients than in the controls. Patients with IBD reported eating fruits (median: 1.33 vs. 1.86, p = 0.003), vegetables (1.22 vs. 2.06, p < 0.001), wholegrain products (0.63 vs. 1.25, p < 0.001), eggs (1.52 vs. 2.11, p < 0.001), milk and dairy products (1.06 vs. 1.81, p < 0.001), plant oils (1.17 vs. 1.49, p = 0.043), nuts and seeds (0.75 vs. 1.47, p < 0.001), spicy foods (0.81 vs. 1.68, p < 0.001) and confectionery products (1.67 vs. 2.20, p = 0.013), as well as beverages such as coffee (1.38 vs. 2.15, p = 0.005), carbonated drinks (0.85 vs. 1.39, p = 0.007) and alcohol (0.61 vs. 1.02, p = 0.003) less frequently compared to the control group. In contrast, they reported consuming refined grain products (1.72 vs. 1.34, p = 0.004) and animal fats (1.62 vs. 1.28, p = 0.046) more frequently than the control group. When comparing the consumption frequency of the most avoided foods within the IBD group with self-reported actual gastrointestinal symptoms within the past 3 months, a statistically significant positive association was noted only between milk consumption and the occurrence of diarrhoea in patients with IBD. This analysis is one of few studies to evaluate dietary patterns in IBD patients and to indicate the most frequently consumed and the most avoided foods.

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Section: Discussionmentioning

confidence: 93%

Assessment of dietary habits in inflammatory bowel disease patients: A cross‐sectional study from Poland

et al. 2021

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“…A properly balanced diet, comprising an adequate supply of proteins, fats, carbohydrates, and macro- and micronutrients, might prevent bone loss and decrease the risk of fractures. Numerous studies indicate that sufficient calcium intake through the use of milk or dairy products may be helpful in patients with IBD, providing proper bone mineralization and increasing BMD [ 36 , 37 , 38 ]. Vitamin D deficiency is also common in IBD patients due to different mechanisms (e.g., intestinal malabsorption, decreased nutritional intake, and/or decreased sunlight exposure), and this negatively impacts the calcium balance and leads to secondary hyperPTH.…”

Section: Inflammatory Bowel Disease (Ibd)mentioning

confidence: 99%

Bone Fragility in Gastrointestinal Disorders

Merlotti

Mingiano

Valenti

et al. 2022

IJMS

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Osteoporosis is a common systemic disease of the skeleton, characterized by compromised bone mass and strength, consequently leading to an increased risk of fragility fractures. In women, the disease mainly occurs due to the menopausal fall in estrogen levels, leading to an imbalance between bone resorption and bone formation and, consequently, to bone loss and bone fragility. Moreover, osteoporosis may affect men and may occur as a sequela to different diseases or even to their treatments. Despite their wide prevalence in the general population, the skeletal implications of many gastrointestinal diseases have been poorly investigated and their potential contribution to bone fragility is often underestimated in clinical practice. However, proper functioning of the gastrointestinal system appears essential for the skeleton, allowing correct absorption of calcium, vitamins, or other nutrients relevant to bone, preserving the gastrointestinal barrier function, and maintaining an optimal endocrine-metabolic balance, so that it is very likely that most chronic diseases of the gastrointestinal tract, and even gastrointestinal dysbiosis, may have profound implications for bone health. In this manuscript, we provide an updated and critical revision of the role of major gastrointestinal disorders in the pathogenesis of osteoporosis and fragility fractures.

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“…1 As a complex and multifaceted disease, osteoporosis incidence can be shaped by a variety of factors including inflammation and dietary intake, with bone mass accumulation and loss in the context of aging being of particular importance in this pathological context. [2][3][4][5] Roughly half of all patients with inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), exhibit a significant reduction in bone mass during the course of their chronic inflammatory disease and are thus at an elevated risk of osteoporotic fractures relative to healthy individuals. [6][7][8] Prior work has firmly established the relationship between inflammatory activity and bone loss.…”

Section: Introductionmentioning

confidence: 99%

Bifidobacterium lactis BL-99 protects mice with osteoporosis caused by colitis via gut inflammation and gut microbiota regulation

et al. 2022

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Milk and dairy product consumption in patients with inflammatory bowel disease: Helpful or harmful to bone mineral density?

Cited by 8 publications

References 46 publications

Assessment of dietary habits in inflammatory bowel disease patients: A cross‐sectional study from Poland

Assessment of dietary habits in inflammatory bowel disease patients: A cross‐sectional study from Poland

Bone Fragility in Gastrointestinal Disorders

Bifidobacterium lactis BL-99 protects mice with osteoporosis caused by colitis via gut inflammation and gut microbiota regulation

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