Milieux de conservation et fonction respiratoire du sang

Bursaux, E; Fréminet, A.; Dubos, C.; Poyart, C

doi:10.1016/s0035-2977(71)80015-9

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Some of the results reported in this study are in full accordance with data already published by us and other laboratories [4,7,11]. They confirm alteration of the respiratory function of blood stored on the ACD medium as evidenced by its low P50 value.…”

Section: Discussionsupporting

confidence: 92%

“…After exchange transfusion (ET) in the neonate or massive transfusion with ACD-stored blood several investigators reported a fall of the P50 7 4 (oxygen partial pressure for half saturation ofhemoglobin, pH 7.4) and discussed its hypothetical consequence: the impairment of the delivery of oxygen to the tissues [7,11,12], In 1957, G ibson et al [9] proposed a new blood storage preservative, the CPD2 solution. In vitro studies of blood stored on this medium showed a better preservation of the 2,3-DPG and of its oxygen transport function as demonstrated by the minor modification of the P50 value, even after 3 weeks of storage [4,6,17]. Recently, exchange transfusion has been proposed for treatment of premature infants with respiratory distress syndrome [8].…”

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confidence: 99%

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Exchange Transfusion in the Neonate with ACD or CPD Stored Blood

Bursaux¹,

Fréminet²,

Brossard³

et al. 1973

Neonatology

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The blood of two groups of five neonates was exchanged to manage a hemolysis due to ABO incompatibility. Exchange transfusions were performed with ACD or CPD blood stored for less than 48 h. Blood oxygen affinity, hemoglobin, and 2,3-diphosphoglycerate concentrations, plasma and erythrolysate pH were measured on blood samples before and several times during the 24 h following the exchange. Infants transfused with CPD blood increased their P50 and 2,3-DPG concentration more rapidly than the group receiving ACD blood. Estimates of oxygen unloading capacities have been calculated, taking into account variations in hemoglobin concentration, P₅₀, and pH. Assuming a constant cardiac output, transfusion with CPD blood might be more valuable than with ACD blood to insure oxygen transport, especially in infants with respiratory or cardiac impairments.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%