Milieu of Diabetes in the 2nd Decade of 21st Century

Abstract

Diabetes mellitus, a multifactorial pathology, is a growing health problem in developed and developing countries of the modern world. Genetic, ethnic, health, dietary habit, sedentary potential, gestational abnormality in addition to other environmental stress factors are the potential stimuli for precipitating diabetic patho-physiology. The chemistry of diabetes and its milieu are multi-directional and cross-connectable. Diabetes is inter-related to hypertension, obesity, atherosclerosis, cardio-arterial disease, stroke and cancer. All these diseases can be transformed from its own pathology to other through some common axle which is still unknown. Advances in modern medicine and biotechnology are in prudent use in global research to strip up the cellular mechanism and its exploitation to bring remedies of these metabolic diseases. The probes of genetic engineering and drug modelling to find less side effects with the advents of information technology, abolition of abnormal genetic messages by DNA/RNA interference and organ grafting with regenerative prostheses by stem cell exploration are among some of the delicate devices to encounter the enmities orchestrated by the inter-locks of these dreadful diseases. This review sieves the prevailing scenario of the disease and its interventions standing in the house of advancements in second decade of this 21 st century.

Difference of Red Blood Cell Count (RBC) Levels in Diabetes Mellitus Type II with Ulcers and without Ulcers

“…Diabetes Mellitus is a metabolic disorder caused by unproductive, not optimal insulin performance or both (Suneja et al, 2018). Diabetes can be categorized into Type I Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM), Gestational Diabetes Mellitus and Diabetes Mellitus which causes are unknown (Ekoe et al, 2018).…”

A comprehensive account of insulin and LDL receptor activity over the years: A highlight on their signaling and functional role

“…[ 102 ] A similar co‐localization of the two receptors in the type‐1 diabetic monocytes and the control THP‐1 cells (in the absence of insulin) was observed. [ 102,103 ] The addition of insulin dissociated the receptor co‐localization in both cases. Moreover, the association of the two receptors in the fasting state was dissociated in vivo by an increased insulin concentration during the follow‐up of the glucose tolerance curve in normal individuals.…”

Atherosclerosis and carcinoma: Two facets of dysfunctional cholesterol homeostasis

“…[21] Reports from our laboratory have shown an inactivation of LDLR on the clearance of LDL particles by its inherent association with the insulin receptor (IR). [13,22] Nonfunctionality of LDLR occurred in such an association due to either absence or inactivity of insulin to navigate IR, thus promoting atherosclerosis. [14,23,24] On the other hand, cholesterol has been targeted as a precancerous molecule.…”