Miliary tuberculosis presenting as skin lesions in a patient with acquired immunodeficiency syndrome

Stack, Rand J.; Bickley, Lynn K.; Coppel, Irving G.

doi:10.1016/0190-9622(90)70331-b

Cited by 50 publications

(16 citation statements)

References 12 publications

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“…In their review published in 1968, Schermer et al [4] described a total of 15 such cases in adult patients. Since then, 22 documented cases have been reported, mainly in the last 8 years [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. Most of them were patients with AIDS [14][15][16][17][18][19][20][21][22][23][24].…”

Section: Discussionmentioning

confidence: 98%

Unusual Cutaneous Manifestations of Miliary Tuberculosis

Giudice

Bernard

Perrin

et al. 2000

Clinical Infectious Diseases

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Cutaneous manifestations of miliary tuberculosis are extremely rare. We describe a 62-year-old woman with leukopenia who developed infiltrated dermal-hypodermal and ulcerative cutaneous lesions during the course of miliary tuberculosis. Miliary tuberculosis was diagnosed when Mycobacterium tuberculosis bacilli were isolated by cultures of the bronchoalveolar lavage fluid and blood and when acid-fast bacilli were detected on histopathologic examination of hepatic, pulmonary, and cutaneous biopsy specimens. With the increasing incidence of immunocompromised patients, unusual presentations of tuberculosis may be observed more often. Acute miliary tuberculosis of the skin is an exceptional manifestation that is due to acute hematogenous dissemination of M. tuberculosis to the skin. We describe a patient who had unusual cutaneous manifestations of miliary tuberculosis.

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Section: Discussionmentioning

confidence: 98%

Unusual Cutaneous Manifestations of Miliary Tuberculosis

Giudice

Bernard

Perrin

et al. 2000

Clinical Infectious Diseases

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“…12 Biopsy of skin lesions represents the earliest and simplest method of diagnosis. 22 Cutaneous miliary tuberculosis in the settings of HIV infection as well as other forms of immunodepression are typically characterized histologically by a lack of granulomatous response and a high bacillary load-analogous to lepromatous leprosy (Table I).…”

Section: Discussionmentioning

confidence: 99%

“…22 Cutaneous miliary tuberculosis in the settings of HIV infection as well as other forms of immunodepression are typically characterized histologically by a lack of granulomatous response and a high bacillary load-analogous to lepromatous leprosy (Table I). 7,[11][12][13][14][15][16][17][18][19][20][21][22] Histological features include an acute inflammatory infiltrate composed exclusively of neutrophils, focal superficial dermal necrosis, and without true caseating granulomas (Table I). 7,8,22 Cutaneous miliary tuberculosis in HIV patients has often been a harbinger of rapid clinical progression and frequent patient demise.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous miliary tuberculosis in two patients with hiv infection

High

Evans

Hoang

2004

Journal of the American Academy of Dermatology

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“…In HIV‐infected patients, the clinical and radiographic appearance of pulmonary tuberculosis is often atypical, and extrapulmonary involvement is frequent. 3 However, specific skin lesions in HIV‐infected patients with tuberculosis are rare, probably because the life expectancy of most HIV‐infected patients with reactivation of tuberculosis has been relatively short, allowing insufficient time for tuberculosis of the skin or mucous membranes to develop. 3 , 4 Recently, new anti‐HIV drugs have improved patients’ immune systems and extended life expectancy, but skin tuberculosis is still rare in HIV‐infected patients.…”

Section: Cold Abscess In Aids Patientsmentioning

confidence: 99%