Miliary Sarcoidosis following Miliary Tuberculosis

Hatzakis, Kostas; Siafakas, Nikolaos M.; Bouros, Demosthenes

doi:10.1159/000029492

Cited by 16 publications

(10 citation statements)

References 13 publications

(11 reference statements)

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“…These include: histopathological appearances of the granulomas [2]; reports of mycobacterial disease either existing coincidentally, succeeding or pre-dating sarcoidosis [59,60]; and the finding of mycobacteria in occasional granulomas of sarcoidosis [61][62][63]. Passage experiments have also suggested that mycobacteria with characteristics of M. tuberculosis may be the incriminating agent [64][65][66][67].…”

Section: Trials Excludedmentioning

confidence: 99%

Molecular evidence for the role of mycobacteria in sarcoidosis: a meta-analysis

Gupta¹,

Agarwal²,

An³

et al. 2007

European Respiratory Journal

186

120

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The aetiology of sarcoidosis is currently unknown. Due to the clinical and histological similarities between sarcoidosis and tuberculosis, the role of mycobacteria has been repeatedly investigated as an aetiological agent for sarcoidosis. The current meta-analysis aimed to evaluate the available molecular evidence on the possible role of mycobacteria in the development of sarcoidosis.The MEDLINE, EMBASE, CINAHL, DARE and CENTRAL databases were searched for relevant studies published from 1980 to 2006, and studies evaluating the presence of mycobacteria using molecular techniques in biological samples of patients with sarcoidosis were included in the current analysis. The 95% confidence intervals (CI) were calculated for the expected proportion (of individual studies); the data was then pooled to obtain a summary success rate with 95% CI. The odds ratio (95% CI) was also calculated in order to assess the presence of mycobacteria in samples of patients with sarcoidosis versus those from nonsarcoidosis control samples.The database search yielded 31 studies. All studies used polymerase chain reaction for nucleic acid amplification followed by identification of nucleic acid sequences specific for different types of mycobacteria. Overall, 231 out of the 874 patients were positive for mycobacteria with a positive signal rate of 26.4 (23.6-29.5%), and the odds of finding mycobacteria in samples of patients with sarcoidosis versus controls were 9.67 (4.56-20.5%) using the random effects model and 19. 49 (11.21-35.54%) using the exact method. There was methodological and statistical heterogeneity and evidence of publication bias.The results of the current study illustrate a demonstrable mycobacterial presence in sarcoidosis lesions suggesting an association between mycobacteria and some cases of sarcoidosis. To avoid methodological diversity, larger multicentre trials with a central laboratory for sample testing should be designed.

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Section: Trials Excludedmentioning

confidence: 99%

Molecular evidence for the role of mycobacteria in sarcoidosis: a meta-analysis

Gupta¹,

Agarwal²,

An³

et al. 2007

European Respiratory Journal

186

120

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“…Some studies [1][2][3][4][5] lend support to this observation. Ning et al, [5] showed the presence of mycobacterial DNA by PCR analysis in 16 of 20 patients with cutaneous lesions of sarcoidosis. The isolation of genetic material from mycobacteria in granulomas of sarcoidosis suggests that the granulomas were initiated by mycobacteria but whether the organisms are viable is still debatable.…”

mentioning

confidence: 79%

Pulmonary and cutaneous sarcoidosis in a treated case of renal tuberculosis

Gupta¹,

Sk²,

Ak³

et al. 2012

Indian J Dermatol Venereol Leprol

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“…Geçmişte sarkoidozu tüberkülozun bir varyasyonu hatta tüberkülozun sarkoid fazı olarak değerlendiren görüşler olmuştur. Ayrıca tüberküloz enfeksiyonundan sonra sarkoidoz geliştiği veya sarkoidoz ile başlayan bir hastalığın tüberkülozla sonlandığı ya da her iki hastalığın bir arada bulunduğu olgular da bildirilmiştir (2,3). Bu iki hastalığın ayırıcı tanısında QFT-GIT testinin kullanılabileceğine dair olgu sunumları dışında bir çalışmaya rastlanmadı.…”

Section: Discussionunclassified

Usefulness of the QuantiFERON-TB GOLD (in Tube) Test for the Differantial Diagnosis of Sarcoidosis from Tuberculosis Lymphadenitis

Özsarı¹,

Şimşek²,

Gözü³

et al. 2017

Turk J Bioch

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ÖzetGİRİŞ ve AMAÇ: Mediastinal benign lenfadenopatinin en sık nedenleri sarkoidoz ve tüberküloz lenfadenit hastalıklarıdır. Çalışmamızda, TB lenfadenitin ayırıcı tanısında yeni yöntemlerden birisi olan QuantiFERON-TB Gold (in tube) (QFT-GIT) testinin değerini araştırmayı amaçladık. YÖNTEM ve GEREÇLER: Toraks BT'de transvers çapı 10 mm ve üzerinde olan mediastinal lenf nodlarının etiyolojisinin araştırılması amacıyla kliniklerimize yönlendirilerek 36'sı sarkoidoz ve 37'si TB lenfadenit tanısı konulan toplam 73 hastanın prospektif olarak yaş, cinsiyet, eşlik eden ek hastalık, tüberküloz temas öyküsü, semptomları, BCG skar sayısı, TCT sonuçları ve QFT-GIT testi sonuçları kaydedildi. BULGULAR: Sarkoidoz hastalarının yaş ortalamaları 42,2±17,2 idi. Olguların 19'u kadın (%52.8), 17'si erkekti (% 47,2). Ortalama takip süreleri 14,6±12,3 ay idi (3 -36 ay). Sarkoidoz ile TB lenfadenit ayırıcı tanısında halen kullanılmakta olan TCT nin, TB lenfadenit tanısında duyarlılığı %62, özgüllüğü %75; QFT-GIT testinin duyarlılığı %92, özgüllüğü %83 olarak hesaplandı. Sarkoidozda QFT-GIT testi ve TCT sonuçları arasında anlamlı korelasyon bulunmazken [p=0,618]; TB lenfadenit için anlamlı korelasyon saptandı [p=0,028]. TARTIŞMA ve SONUÇ: Ülkemizde olduğu gibi rutin BCG aşılamasının ve TCT sonucuna göre yeniden aşılanmaların uygulandığı topluluklarda, tüberküloz enfeksiyonun ayırıcı tanısında BCG den etkilenmeyen QFT-GIT testinin TCT ile birlikte kullanılması önerilebilir. Ayrıca sistemik steroid tedavisi alması planlanan hastalarda INH proflaksisi başlanması için tek başına TCT'den ziyade QFT-GIT testi pozitifliğinin gözönüne alınması uygun olabilir. Abstract INTRODUCTION:There is one of the new methods in the differential diagnosis QuantiFERON-TB Gold (in tube) (QFT-GIT), in which the most common cause of sarcoidosis and tuberculosis lymphadenitis of benign mediastinal lymphadenopathy, we aimed to investigate the value of the test for TB lymphadenitis. METHODS: Chest CT transverse diameter of 10 mm and directed to our clinic to investigate the etiology of mediastinal lymph nodes above sarcoidosis was diagnosed in 36 patients with TB lymphadenitis was diagnosed in 37 patients, including 73 patients age, sex, comorbid disease, the tuberculosis contact history, symptoms, number of BCG scar, TST and QFT-GIT results were recorded test results. RESULTS: The mean age of patients with sarcoidosis 42.2± 17.2) were female (52.8%), 17 were male (47.2%). Average follow-up time was 14.6 ± 12.3 months. (3-36 months). With sarcoidosis, which is still being used in the differential diagnosis of TB lymphadenitis, TCT's sensitivity in diagnosis of TB lymphadenitis was 62%, specificity 75%; QFT-GIT sensitivity of the test was 92%, specificity of 83% was calculated. Sarcoidosis QFT-GIT and TST test results of there were no significant correlation between [p = 0.618]; Significant correlation was found for TB lymphadenitis [p = 0.028]. DISCUSSION AND CONCLUSION: As our country and communities of routine BCG vaccination should be vaccinated again applied a...

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Miliary Sarcoidosis following Miliary Tuberculosis

Cited by 16 publications

References 13 publications

Molecular evidence for the role of mycobacteria in sarcoidosis: a meta-analysis

Molecular evidence for the role of mycobacteria in sarcoidosis: a meta-analysis

Pulmonary and cutaneous sarcoidosis in a treated case of renal tuberculosis

Usefulness of the QuantiFERON-TB GOLD (in Tube) Test for the Differantial Diagnosis of Sarcoidosis from Tuberculosis Lymphadenitis

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