Miliary haemangiomata in the newborn.

Burman, David; Mansell, Peter W.A.; Warin, Robert P.

doi:10.1136/adc.42.222.193

Cited by 57 publications

(22 citation statements)

References 4 publications

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“…This high frequency of central nervous system involvement is unprecedented, and does not reflect the reports in the literature thereafter. Most of the infants described in this study and in other case reports [5,6,7,8,9,10,11,12,13,14,15,16,17,18] were symptomatic, with symptoms such as increased head circumference, flaccid paralysis, cranial nerve palsy, decreased rectal tone, areflexia, and others. Radiological findings in these cases include IHs, but also hemorrhages and hydrocephalus.…”

Section: Introductionsupporting

confidence: 51%

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Screening for Brain Involvement in Infants with Multifocal Cutaneous Infantile Hemangiomas

Friedland¹,

Amitai²,

Zvulunov³

2017

Dermatology

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Background: Multifocal (≥5) infantile hemangiomas (IHs) are known as a risk factor for extracutaneous involvement. Liver is the most commonly involved organ, but involvement of other systems has also been reported. This study aims to describe the characteristic findings in a group of infants with multiple cutaneous hemangiomas, with emphasis on intracranial involvement. Methods: A retrospective case series study was carried out in a pediatric dermatology unit of a tertiary pediatric medical center. Patients diagnosed with multiple cutaneous IHs from 2006 to 2015 were identified by a computerized search. Clinical data were retrieved from the medical charts. Results: A total of 60 infants (37 females and 23 males) were identified for analysis. Forty-four brain ultrasounds were recorded and reported as normal. One patient out of the 44 was later diagnosed with a small asymptomatic hemangioma seen on a brain MRI/MRA done for another indication. Conclusion: Brain hemangiomas may present as an asymptomatic incidental finding in infants presenting with multifocal cutaneous and liver IHs. The single case reported in our study emphasizes the low prevalence and the benign course expected. Therefore, routine ultrasound screening for brain involvement is probably unnecessary for this population.

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Section: Introductionsupporting

confidence: 51%

“…A literature search revealed 15 other cases described with multifocal IHs and brain involvement [5,6,7,8,9,10,11,12,13,14,15,16,17,18]. Table 2 summarizes the data reported for these cases including our patient.…”

Section: Discussionmentioning

confidence: 85%

Screening for Brain Involvement in Infants with Multifocal Cutaneous Infantile Hemangiomas

Friedland¹,

Amitai²,

Zvulunov³

2017

Dermatology

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“…When fatal, autopsy will show multiple haemangiomas in several organs, the majority of which have offered no overt clinical symptoms [3,10,17], The prognosis is generally dubious especially when symptoms are secondary to lesions in the central nervous system [2,10], in the digestive tract [17] and circulation -mainly a-v fistulae in lungs and liver [1,2,4], Of the mentioned 21 cases reviewed by Fryns et al [9] only 4 survived. McLean el al.…”

Section: Discussionmentioning

confidence: 99%

A Case of Multiple Neonatal Haemangiomatosis Successfully Treated by Systemic Corticosteroids

Clemmensen¹

1979

Dermatology

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A case of multiple neonatal haemangiomatosis is reported. The disease entity is rare and probably always combined with haemangiomas of internal organs. When visceral involvement provokes clinical symptoms (cardiac, cerebral, gastrointestinal), the spontaneous course often proves fatal. The prognosis seems to improve substantially if treatment with systemic corticosteroids is instituted. The patient reported, who had concomitant cardiac and gastrointestinal symptoms, recovered completely following corticosteroid treatment. It is concluded that steroid treatment is indicated without hazards in complicated cases of multiple neonatal haemangiomatosis.

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“…Transillumi nation and compression of the bowel wall are helpful techniques in finding small lesions. Repeated operations may be necessary to control GI bleeding [7,14], Universal (miliary) hemangiomatosis is a rare disorder, usually fatal in infancy, in which there are hundreds of hemangiomas involving the skin, brain, lung, and abdomi nal viscera [15]. GI hemangiomas rarely are of significance.…”

Section: Hemangiomasmentioning

confidence: 99%