Milestones and current achievements in development of multifunctional bioscaffolds for medical application

Litowczenko, Jagoda; Woźniak-Budych, Marta J.; Staszak, Katarzyna; Wieszczycka, Karolina; Jurga, Stefan; Tylkowski, Bartosz

doi:10.1016/j.bioactmat.2021.01.007

Cited by 56 publications

(39 citation statements)

References 328 publications

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“…Biopolymers, such as PCL and PLA, succeeded in matching the requirements for biodegradable materials with prolonged life-time and mechanical resistance inside the body. On the other hand, the chemical moieties available in these synthetic polymers are not capable to actively promote cellular interactions 26 , 27 .…”

Section: Introductionmentioning

confidence: 99%

Advanced mycelium materials as potential self-growing biomedical scaffolds

Antinori

Contardi

Suarato

et al. 2021

Sci Rep

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Mycelia, the vegetative part of fungi, are emerging as the avant-garde generation of natural, sustainable, and biodegradable materials for a wide range of applications. They are constituted of a self-growing and interconnected fibrous network of elongated cells, and their chemical and physical properties can be adjusted depending on the conditions of growth and the substrate they are fed upon. So far, only extracts and derivatives from mycelia have been evaluated and tested for biomedical applications. In this study, the entire fibrous structures of mycelia of the edible fungi Pleurotus ostreatus and Ganoderma lucidum are presented as self-growing bio-composites that mimic the extracellular matrix of human body tissues, ideal as tissue engineering bio-scaffolds. To this purpose, the two mycelial strains are inactivated by autoclaving after growth, and their morphology, cell wall chemical composition, and hydrodynamical and mechanical features are studied. Finally, their biocompatibility and direct interaction with primary human dermal fibroblasts are investigated. The findings demonstrate the potentiality of mycelia as all-natural and low-cost bio-scaffolds, alternative to the tissue engineering systems currently in place.

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Section: Introductionmentioning

confidence: 99%

Advanced mycelium materials as potential self-growing biomedical scaffolds

Antinori

Contardi

Suarato

et al. 2021

Sci Rep

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“…Recently, two key routes of scaffold fabrication have been developed. The first involves the production of matrices with previously designed three-dimensional architecture, e.g., by 3D printing [ 16 , 17 , 18 , 19 ], macro-porous hydrogels synthesis [ 20 , 21 , 22 ], or electrospinning [ 23 , 24 ]. The second uses renewable decellularized natural sources of prefabricated scaffolds in their original shape, e.g., autogenic or allogenic ECM [ 25 , 26 , 27 ], skeletons with proper architecture [ 28 , 29 ] or plant-based structure [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Naturally Formed Chitinous Skeleton Isolated from the Marine Demosponge Aplysina fistularis as a 3D Scaffold for Tissue Engineering

et al. 2021

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Tissue engineering (TE) is a field of regenerative medicine that has been experiencing a special boom in recent years. Among various materials used as components of 3D scaffolds, naturally formed chitinous materials seem to be especially attractive because of their abundance, non-toxic and eco-friendly character. In this study, chitinous skeleton isolated from the marine sponge Aplysina fistularis (phylum: Porifera) was used for the first time as a support for the cultivation of murine fibroblasts (Balb/3T3), human dermal fibroblasts (NHDF), human keratinocyte (HaCaT), and human neuronal (SH-SY5Y) cells. Characterization techniques such as ATR FTIR, TGA, and μCT, clearly indicate that an interconnected macro-porous, thermostable, pure α-chitin scaffold was obtained after alkali–acid treatment of air-dried marine sponge. The biocompatibility of the naturally formed chitin scaffolds was confirmed by cell attachment and proliferation determined by various microscopic methods (e.g., SEM, TEM, digital microscopy) and specific staining. Our observations show that fibroblasts and keratinocytes form clusters on scaffolds that resemble a skin structure, including the occurrence of desmosomes in keratinocyte cells. The results obtained here suggest that the chitinous scaffold from the marine sponge A. fistularis is a promising biomaterial for future research about tissues regeneration.

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“…Multifunctional 3D bioscaffolds are developed to stimulate the regrowth of tissue. Bioactive scaffolds can be enriched with living cells of different origins, bioactive molecules or enzymes to not only provide mechanical strength and guidance for autologous tissue regrowth but also restore functional tissue properties [8,9]. Target tissues for artificial engineering include bone, cartilage, muscle, nerves, cardiovascular tissue and skin.…”

Section: Introductionmentioning

confidence: 99%

Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration

Emmert

Pantermehl

Foth

et al. 2021

IJMS

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Skin regeneration is a quite complex process. Epidermal differentiation alone takes about 30 days and is highly regulated. Wounds, especially chronic wounds, affect 2% to 3% of the elderly population and comprise a heterogeneous group of diseases. The prevailing reasons to develop skin wounds include venous and/or arterial circulatory disorders, diabetes, or constant pressure to the skin (decubitus). The hallmarks of modern wound treatment include debridement of dead tissue, disinfection, wound dressings that keep the wound moist but still allow air exchange, and compression bandages. Despite all these efforts there is still a huge treatment resistance and wounds will not heal. This calls for new and more efficient treatment options in combination with novel biocompatible skin scaffolds. Cold atmospheric pressure plasma (CAP) is such an innovative addition to the treatment armamentarium. In one CAP application, antimicrobial effects, wound acidification, enhanced microcirculations and cell stimulation can be achieved. It is evident that CAP treatment, in combination with novel bioengineered, biocompatible and biodegradable electrospun scaffolds, has the potential of fostering wound healing by promoting remodeling and epithelialization along such temporarily applied skin replacement scaffolds.

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Milestones and current achievements in development of multifunctional bioscaffolds for medical application

Cited by 56 publications

References 328 publications

Advanced mycelium materials as potential self-growing biomedical scaffolds

Advanced mycelium materials as potential self-growing biomedical scaffolds

Naturally Formed Chitinous Skeleton Isolated from the Marine Demosponge Aplysina fistularis as a 3D Scaffold for Tissue Engineering

Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration

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