Mildronate in cardiology practice – current evidence, ongoing research, and future perspectives

Михин, В. П.; Поздняков, Ю. М.; Хлебодаров, Ф. Е.; Koltsova, O. N.

doi:10.15829/1728-8800-2012-1-96-103

Cited by 5 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It also restores the balance of oxygen delivery and consumption in cells; and prevents ATP transport disruptions. At the same time, glycolysis is activated, which occurs without additional oxygen consumption [20,21].…”

Section: Figure 2 the Relaxing Effect Of The Ach And Melarginine On I...mentioning

confidence: 99%

L-arginine, inosine and meldonium effect on the vascular wall reactivity of adult rats

Sykalo,

Kuprash,

Panteleymonova

2024

A&L

View full text Add to dashboard Cite

Changes in the structure, metabolism and cardiovascular system function that develop during ageing are the basis for the circulatory pathology occurrence in old age. Currently, cardiovascular system diseases are one of the main causes of mortality in almost all developed countries. Therefore, searching for new drugs to correct the metabolism and functions of organs and systems whose activity is disrupted during ageing is an urgent problem. The article presents the study influence results of the synthesis precursor of endothelial relaxing factor - NO (ERF-NO) L-arginine, the purine nucleoside inosine and the β-oxidation inhibitor of fatty acids meldonium on the vascular wall reactivity of adult rats. When used separately, these drugs have been shown to cause slight relaxation of the thoracic aorta isolated segments in adult animals. When L-arginine, inosine and meldonium are used together, there is no summation of their pharmacological effect on blood vessels, however, some vasodilator effect potentiation is observed. The acetylcholine (Ach) vasodilator effect was significantly more than the vasodilator effect of the studied composition (L-arginine + inosine + meldonium), conventionally called Melarginine. It should be noted that, although the vasodilator Ach effect was significant, it was short-term, and the vasodilator effect of the studied combination (Melarginine) was long-lasting. A pronounced vasodilator response to Ach indicates the preservation of the endothelium in adult rats. Therefore, with intact endothelium in adult animals, Melarginine does not cause significant vascular relaxation. In aged rats, which typically exhibit endothelial damage, the effect of Melarginine may be more significant compared to adults. This will be the subject of our further study. Still, Melarginine has a small but long-lasting vasodilatory effect in adult rats, which also helps regulate vascular tone. _________________________________________________________________________________________ Keywords: vessel reactivity; endothelial dysfunction; L-arginine; inosine; meldonium; Melarginine

show abstract

Section: Figure 2 the Relaxing Effect Of The Ach And Melarginine On I...mentioning

confidence: 99%

L-arginine, inosine and meldonium effect on the vascular wall reactivity of adult rats

Sykalo,

Kuprash,

Panteleymonova

2024

A&L

View full text Add to dashboard Cite

show abstract

“…В ряде рандомизированных двойных слепых плацебо-контролируемых исследований по изучению эффективности и безопасности Милдроната продемонстрировано повышение толерантности пациентов к физическим нагрузкам (ТФН), увеличение времени до возникновения приступа стенокардии, увеличение времени до возникновения депрессии сегмента ST, улучшение качества жизни пациентов [11][12][13].…”

unclassified

Comparative effectiveness of the approaches to correct vascular structural and functional disturbances in postmenopausal women

Tolstov

Мычка

Салов

et al. 2012

Cardiovasc Ther Prev

View full text Add to dashboard Cite

Aim.To compare the effects of Mildronate and hormone replacement therapy (HRT) with estradiol (1 mg) and drospirenone, DSPR (2 mg) on circadian blood pressure (BP) profile, arterial structure and function, and vascular stiffness parameters in women with early postmenopause and climacteric syndrome (CS).Material and methods.The study included 94 women with early postmenopause and CS, who provided written informed consent to participate and were divided into two groups. Group I included 36 women receiving Mildronate (500 mg twice a day), while Group II included 28 women who were administered, according to clinical indications, HRT (1 mg 17β-estradiol and 2 mg DRSP once a day). The control group (CG) included 30 women who did not receive either Mildronate or DRSP. At baseline and 16 weeks later, all participants underwent the assessment of blood biochemistry; intima-media thickness (IMT) of common carotid artery (CCA); endothelium-dependent vasodilatation (EDVD) of brachial artery (BA); antithrombogenic activity of vascular wall; aortal pulse wave velocity (aPWV); arterial stiffness; and 24-hour BP monitoring (BPM).Results.The study demonstrated positive effects of Mildronate therapy and HRT (1 mg 17β-estradiol and 2 mg DRSP) on metabolic status, circadian dynamics and variability (Var) of BP, and arterial structure and function. The largest positive changes in blood lipid profile were observed in Group I and II patients. By the end of the study, these patients demonstrated significantly decreased levels of systolic and diastolic BP and reduced BP Var, particularly in Group II. Mildronate therapy, but not HRT, was associated with normalisation of vascular wall antiaggregant potential. Group II demonstrated a significant reduction in CCA IMT levels, with a similar tendency in Group I. In both groups, the degree of endothelial dysfunction (ED) decreased, which was manifested in increased BA EDVD, decreased aPWV, and reduced arterial stiffness and was more pronounced in Group II.Conclusion.In menopausal women with CS, the effects of Mildronate and HRT on metabolic, structural, and functional disturbances were similar. Therefore, Mildronate therapy could be a new method of correction of these systemic disturbances.

show abstract

Cardioprotective effects of a new glutamic acid derivative in chronic alcohol intoxication

Перфилова

Kustova

Popova

et al. 2021

Alcohol

View full text Add to dashboard Cite

Mildronate in cardiology practice – current evidence, ongoing research, and future perspectives

Cited by 5 publications

References 30 publications

L-arginine, inosine and meldonium effect on the vascular wall reactivity of adult rats

L-arginine, inosine and meldonium effect on the vascular wall reactivity of adult rats

Comparative effectiveness of the approaches to correct vascular structural and functional disturbances in postmenopausal women

Cardioprotective effects of a new glutamic acid derivative in chronic alcohol intoxication

Contact Info

Product

Resources

About