Mildly oxidized HDL decrease agonist-induced platelet aggregation and release of pro-coagulant platelet extracellular vesicles

Tafelmeier, Maria; Fischer, Astrid; Orsó, Evelyn; Konovalova, Tatiana; Böttcher, Alfred; Liebisch, Gerhard; Matysik, Silke; Schmitz, Gerd

doi:10.1016/j.jsbmb.2016.05.003

Cited by 15 publications

(11 citation statements)

References 71 publications

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“…2). However, Tafelmeier et al showed that CD36 and SR-B1 mediate more efficient phospho-and sphingolipid remodeling in the absence of ABCA1 on platelet [16]. At present, there is Fig.…”

Section: The Effects Of Lipid Metabolism On Biosynthesis Secretion Amentioning

confidence: 93%

“…2 ). However, Tafelmeier et al showed that CD36 and SR-B1 mediate more efficient phospho- and sphingolipid remodeling in the absence of ABCA1 on platelet [ 16 ]. At present, there is little evidence that lipids play a key role in the formation and release of exosomes, and it has not been fully understood and requires further explored.…”

Section: The Effects Of Lipid Metabolism On Biosynthesis Secretion Amentioning

confidence: 99%

“…Conversely, increasing evidence indicated that lipid metabolism also affects biological processes of exosomes, including biosynthesis and interactions with recipient cells, which probably because lipids are the major components of bio-film systems and affect their fluidity. It has been confirmed that ABCA1-mediated cholesterol efflux can promote the release of exosomes, while SR-B1-mediated cholesterol efflux can inhibit the absorption of exosomes by recipient cells [16]. However, the relationship between exosomes and lipid metabolism is still unclear.…”

Section: Introductionmentioning

confidence: 99%

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The crosstalk: exosomes and lipid metabolism

et al. 2020

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Exosomes have been considered as novel and potent vehicles of intercellular communication, instead of "cell dust". Exosomes are consistent with anucleate cells, and organelles with lipid bilayer consisting of the proteins and abundant lipid, enhancing their "rigidity" and "flexibility". Neighboring cells or distant cells are capable of exchanging genetic or metabolic information via exosomes binding to recipient cell and releasing bioactive molecules, such as lipids, proteins, and nucleic acids. Of note, exosomes exert the remarkable effects on lipid metabolism, including the synthesis, transportation and degradation of the lipid. The disorder of lipid metabolism mediated by exosomes leads to the occurrence and progression of diseases, such as atherosclerosis, cancer, nonalcoholic fatty liver disease (NAFLD), obesity and Alzheimer's diseases and so on. More importantly, lipid metabolism can also affect the production and secretion of exosomes, as well as interactions with the recipient cells. Therefore, exosomes may be applied as effective targets for diagnosis and treatment of diseases.

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“…2). However, Tafelmeier et al showed that CD36 and SR-B1 mediate more efficient phospho-and sphingolipid remodeling in the absence of ABCA1 on platelet [16]. At present, there is Fig.…”

Section: The Effects Of Lipid Metabolism On Biosynthesis Secretion Amentioning

confidence: 93%

Section: The Effects Of Lipid Metabolism On Biosynthesis Secretion Amentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The crosstalk: exosomes and lipid metabolism

et al. 2020

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“…Recent studies showed that, in human serum, most EVs are P-EVs, although EVs can also be generated from white blood cells and cancer cells 15 - 17 . P-EVs have been found to participate in a variety of important biological and pathological processes via intracellular communication 18 , 19 , including clotting 20 , 21 , angiogenesis 22 , 23 , inflammation 24 , 25 , immunoregulation 3 , cellular prion protein transport 26 , and tumor progression 25 , 27 .…”

Section: Introductionmentioning

confidence: 99%

Platelet-derived Extracellular Vesicles: An Emerging Therapeutic Approach

2017

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Extracellular vesicles (EVs) are a newly-discovered way by which cells communicate with their neighbors, as well as transporting cargos which once were considered to be limited by membrane barriers, including membrane proteins, cytosolic proteins and RNA. The discovery of platelet-derived EVs (P-EVs), the most abundant EVs in human blood, has been a very tortuous process. At first, P-EVs were identified as nothing but 'platelet dust', and subsequent research did not progress smoothly because of the limited research techniques to study EVs. Following leaps and bounds of technical progress in studying EVs, more and more attractive features of P-EVs were revealed and they began to be further researched. The aim of this review is to present the latest knowledge about the role of P-EVs in tissue repair and tumor progression. The potential mechanism of P-EVs is emphasized. Then the limitations of the present study and future research directions are discussed.

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“…Sphingosine-1-phosphate (S1P), which is released from activated platelets, modulates a wide spectrum of biological activities, including protecting cells from apoptosis ( Ahmed et al ., 2015 ), activating calcium signaling ( Ruger et al ., 2014 ), and stimulating nitric oxide production ( Cui et al ., 2017 ). Additional effects include effects on cell proliferation ( Zhai et al ., 2017 ), regulation of adhesion molecule expression ( Wetter et al ., 2009 ), stimulation of tumor cell invasion, aggregation of platelets ( Tafelmeier et al ., 2017 ), inhibition of cell migration ( Filipenko et al ., 2016 ), and contraction of smooth muscle cells ( Shaifta et al ., 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of Sphingosine-1-Phosphate on Intracellular Free Ca²⁺ in Cat Esophageal Smooth Muscle Cells

Lee

Min

Yoo

et al. 2018

Biomolecules & Therapeutics

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A comprehensive collection of proteins senses local changes in intracellular Ca2+ concentrations ([Ca2+]i) and transduces these signals into responses to agonists. In the present study, we examined the effect of sphingosine-1-phosphate (S1P) on modulation of intracellular Ca2+ concentrations in cat esophageal smooth muscle cells. To measure [Ca2+]i levels in cat esophageal smooth muscle cells, we used a fluorescence microscopy with the Fura-2 loading method. S1P produced a concentration-dependent increase in [Ca2+]i in the cells. Pretreatment with EGTA, an extracellular Ca2+ chelator, decreased the S1P-induced increase in [Ca2+]i, and an L-type Ca2+-channel blocker, nimodipine, decreased the effect of S1P. This indicates that Ca2+ influx may be required for muscle contraction by S1P. When stimulated with thapsigargin, an intracellular calcium chelator, or 2-Aminoethoxydiphenyl borate (2-APB), an InsP3 receptor blocker, the S1P-evoked increase in [Ca2+]i was significantly decreased. Treatment with pertussis toxin (PTX), an inhibitor of Gi-protein, suppressed the increase in [Ca2+]i evoked by S1P. These results suggest that the S1P-induced increase in [Ca2+]i in cat esophageal smooth muscle cells occurs upon the activation of phospholipase C and subsequent release of Ca2+ from the InsP3-sensitive Ca2+ pool in the sarcoplasmic reticulum. These results suggest that S1P utilized extracellular Ca2+ via the L type Ca2+ channel, which was dependent on activation of the S1P4 receptor coupled to PTX-sensitive Gi protein, via phospholipase C-mediated Ca2+ release from the InsP3-sensitive Ca2+ pool in cat esophageal smooth muscle cells.

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Mildly oxidized HDL decrease agonist-induced platelet aggregation and release of pro-coagulant platelet extracellular vesicles

Cited by 15 publications

References 71 publications

The crosstalk: exosomes and lipid metabolism

The crosstalk: exosomes and lipid metabolism

Platelet-derived Extracellular Vesicles: An Emerging Therapeutic Approach

Effect of Sphingosine-1-Phosphate on Intracellular Free Ca²⁺ in Cat Esophageal Smooth Muscle Cells

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Mildly oxidized HDL decrease agonist-induced platelet aggregation and release of pro-coagulant platelet extracellular vesicles

Cited by 15 publications

References 71 publications

The crosstalk: exosomes and lipid metabolism

The crosstalk: exosomes and lipid metabolism

Platelet-derived Extracellular Vesicles: An Emerging Therapeutic Approach

Effect of Sphingosine-1-Phosphate on Intracellular Free Ca2+ in Cat Esophageal Smooth Muscle Cells

Contact Info

Product

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Effect of Sphingosine-1-Phosphate on Intracellular Free Ca²⁺ in Cat Esophageal Smooth Muscle Cells