2008
DOI: 10.1016/j.expneurol.2008.03.012
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Mild traumatic brain injury to the infant mouse causes robust white matter axonal degeneration which precedes apoptotic death of cortical and thalamic neurons

Abstract: The immature brain in the first several years of childhood is very vulnerable to trauma. Traumatic brain injury (TBI) during this critical period often leads to neuropathological and cognitive impairment. Previous experimental studies in rodent models of infant TBI were mostly concentrated on neuronal degeneration, while axonal injury and its relationship to cell death have attracted much less attention. To address this, we developed a closed controlled head injury model in infant (P7) mice and characterized t… Show more

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Cited by 86 publications
(79 citation statements)
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“…However, Pierce and associates did not specifically identify nigrostriatal dopaminergic axons or axon collaterals in their report. In addition, TBI results in a number of cellular events that are related to excitotoxic cell death, apoptosis, and the induction of autophagy (Clark et al, 2008;Conti et al, 1998;Dikranian et al, 2008;Fiskum, 2000;Hutchison et al, 2001;Raghupathi, 2004). TBI-induced axonal injury results in the release and unregulated movement of intracellular and extracellular substances, including ions, neurotransmitters, proteins, and lipids.…”
Section: The Effect Of Tbi On Nigrostriatal Dopaminergic Neuronsmentioning
confidence: 99%
“…However, Pierce and associates did not specifically identify nigrostriatal dopaminergic axons or axon collaterals in their report. In addition, TBI results in a number of cellular events that are related to excitotoxic cell death, apoptosis, and the induction of autophagy (Clark et al, 2008;Conti et al, 1998;Dikranian et al, 2008;Fiskum, 2000;Hutchison et al, 2001;Raghupathi, 2004). TBI-induced axonal injury results in the release and unregulated movement of intracellular and extracellular substances, including ions, neurotransmitters, proteins, and lipids.…”
Section: The Effect Of Tbi On Nigrostriatal Dopaminergic Neuronsmentioning
confidence: 99%
“…In the ipsilateral thalamus, we observed an increase in IGF-1R at 72 h. This delayed increase in thalamic IGF-1R may be in response to axonal injury of thalamocortical projections. Axonal injury in the SCWM after mild TBI is reported to cause apoptotic cell death in thalamic neurons (Dikranian et al, 2008).…”
Section: Figmentioning
confidence: 99%
“…In an in vitro model of TBI using cortical and hippocampal brain slice cultures, moderate mechanical stimuli in excess of 10% biaxial deformation were required to induce significant cell death . However, cellular or network electrophysiological function may be altered even in the absence of gross behavioral changes during the acute period after mild injury (Dikranian et al 2008). Clinically subtle symptoms in the acute posttraumatic period that could be overlooked may lead to diagnosis of cerebral palsy, learning disabilities, and complex behavioral disorders later in childhood (Barlow et al 2005;Christensen et al 2009).…”
Section: Introductionmentioning
confidence: 99%