Mild traumatic brain injury as a pathological process

Naumenko, Yana; Yuryshinetz, Irada; Zabenko, Yelyzaveta; Pivneva, Tetyana

doi:10.1016/j.heliyon.2023.e18342

Cited by 8 publications

(5 citation statements)

References 118 publications

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“…Closed Head Injury The most common type of CHI is mild TBI—meaning not immediately life-threatening (around 80% of all diagnoses [ 105 ])–a sub-type of closed head injury (CHI) occurring within an intact skull that is caused by bumps to the head or any other action causing fast skull movement (acceleration/deceleration, especially rotational [ 110 ]), which may result in physical strain to the brain and/or chemical changes. These accelerations usually involve coup contrecoup: the back-and-forth jarring of the brain against the skull’s inner walls, shearing tissue and resulting in blood vessel rupture, bruising, and swelling.…”

Section: Brain Damagementioning

confidence: 99%

“…This kind of injury is relatively common in any physically intensive activity (sports, military practice) or as a result of acts of violence and accidents (traffic, falls). It can cause some of the aforementioned symptoms immediately after injury (peaking within the first 24 h), during which the brain undergoes gliosis—glial cell multiplication, forming scars [ 110 ]. Such a process hinders healing but also entails potential long-term effects [ 111 , 112 , 113 ] such as chronic traumatic encephalopathy (CTE) in the case of recurrent mild TBI, common in sportsmen.…”

Section: Brain Damagementioning

confidence: 99%

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Review of the Brain’s Behaviour after Injury and Disease for Its Application in an Agent-Based Model (ABM)

Irastorza-Valera,

Soria-Gómez,

Benitez

et al. 2024

Biomimetics

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The brain is the most complex organ in the human body and, as such, its study entails great challenges (methodological, theoretical, etc.). Nonetheless, there is a remarkable amount of studies about the consequences of pathological conditions on its development and functioning. This bibliographic review aims to cover mostly findings related to changes in the physical distribution of neurons and their connections—the connectome—both structural and functional, as well as their modelling approaches. It does not intend to offer an extensive description of all conditions affecting the brain; rather, it presents the most common ones. Thus, here, we highlight the need for accurate brain modelling that can subsequently be used to understand brain function and be applied to diagnose, track, and simulate treatments for the most prevalent pathologies affecting the brain.

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Section: Brain Damagementioning

confidence: 99%

Section: Brain Damagementioning

confidence: 99%

Review of the Brain’s Behaviour after Injury and Disease for Its Application in an Agent-Based Model (ABM)

Irastorza-Valera,

Soria-Gómez,

Benitez

et al. 2024

Biomimetics

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“…There are concluding signs of comorbidity with several mental conditions such as Major Depression (MD), Post-Traumatic Stress-Disorder (PTSD), general anxiety and suicidal behaviour [89] -and even sleep disorders, back pain, high cholesterol, osteoarthritis and diabetes [90]. The most common type is mild TBI -meaning not immediately life-threatening (around 80% of all diagnoses [86]), a sub-type of closed head injury (CHI) -occurring within an intact skull -caused by bumps to the head or any other action causing fast skull movement (acceleration/deceleration, especially rotational [91]) which may result in physical strain to the brain and/or chemical changes. These accelerations usually involve coup -contrecoup: back-and-forth jarring of the brain against the skull's inner walls shearing tissue and resulting in blood vessel rupture, bruising and swelling.…”

Section: External: Traumatic Brain Injurymentioning

confidence: 99%

“…It is relatively common in any physically intensive activity (sports, military practice), acts of violence or accidents (traffic, falls), and can cause some of the aforementioned physical or behavioural symptoms, normally immediately after injury (peaking within the first 24h, during which the brain undergoes gliosis -scar-like multiplication and/or growth of glial cells [91], hindering healing) but entailing potential long-term effects [92][93][94] such as Chronic Traumatic Encephalopathy (CTE) in the case of recurrent milt TBI, typical in sportsmen (up to 90% of athletes in the US [95]) who may experience memory and attention impairments, suicidal behaviour or even cardiovascular complications [96,97].…”

Section: Closed Head Injurymentioning

confidence: 99%

Review of the Brain Behaviour after Injury and Disease for Its Application in an Agent Based Model (ABM)

Irastorza Varela,

Benítez Baena,

Montans

et al. 2023

Preprint

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The brain being arguably the most complex organ in the human body, its detailed functioning is yet to be fully deciphered, let alone accurately modeled. Nonetheless, the medical community has gathered quite a remarkable amount of studies about the consequences of illnesses and injuries on its development and functioning. This bibliographic review aims to cover mostly the findings related to the changes in the physical distribution of neurons and their connections - the connectome -, both structural and functional, as well as their modelling. It does not intend to offer an extensive medical description of all injuries and diseases affecting the brain, rather presenting the most common ones succinctly so the need for accurate brain modelling can be fully understood and pondered, offering propositions to this aim.

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“…The second one, conversely, does not involve bleeding in the brain, being characterized by damage to brain tissues without blood vessel rupture. This type of injury may include brain contusions, concussions, and diffuse axonal injuries [ 57 ].…”

Section: Introductionmentioning

confidence: 99%

Cellular and Molecular Pathophysiology of Traumatic Brain Injury: What Have We Learned So Far?

Freire,

Rocha,

Bittencourt

et al. 2023

Biology

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Traumatic brain injury (TBI) is one of the leading causes of long-lasting morbidity and mortality worldwide, being a devastating condition related to the impairment of the nervous system after an external traumatic event resulting in transitory or permanent functional disability, with a significant burden to the healthcare system. Harmful events underlying TBI can be classified into two sequential stages, primary and secondary, which are both associated with breakdown of the tissue homeostasis due to impairment of the blood–brain barrier, osmotic imbalance, inflammatory processes, oxidative stress, excitotoxicity, and apoptotic cell death, ultimately resulting in a loss of tissue functionality. The present study provides an updated review concerning the roles of brain edema, inflammation, excitotoxicity, and oxidative stress on brain changes resulting from a TBI. The proper characterization of the phenomena resulting from TBI can contribute to the improvement of care, rehabilitation and quality of life of the affected people.

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Mild traumatic brain injury as a pathological process

Cited by 8 publications

References 118 publications

Review of the Brain’s Behaviour after Injury and Disease for Its Application in an Agent-Based Model (ABM)

Review of the Brain’s Behaviour after Injury and Disease for Its Application in an Agent-Based Model (ABM)

Review of the Brain Behaviour after Injury and Disease for Its Application in an Agent Based Model (ABM)

Cellular and Molecular Pathophysiology of Traumatic Brain Injury: What Have We Learned So Far?

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