Mild-to-moderate iodine deficiency in a sample of pregnant women and salt iodine concentration from Zhejiang province, China

Yu, Zengli; Zheng, Canjie; Zheng, Wangfeng; Wan, Zhongxiao; Bu, Yongjun; Zhang, Guofu; Ding, Shibin; Wang, Erhui; Zhai, Desheng; Feei, Zheng

doi:10.1007/s10653-020-00640-0

Cited by 17 publications

(12 citation statements)

References 37 publications

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“…A survey conducted in Dalian and Shenyang, China, found that the proportions of pregnant women with iodine deficiency, adequate iodine levels, more than adequate iodine levels, and iodine excess were 48.2%, 34.2%, 14.5%, and 3.2%, respectively [ 11 ]. In another survey conducted in the Zhejiang province, China, 61.7% and 2% of the pregnant women had iodine deficiency and iodine excess, respectively, while 20.9% had sufficient iodine levels [ 12 ]. The Chinese capital Beijing is an iodine-sufficient region that has implemented the USI policy.…”

Section: Discussionmentioning

confidence: 99%

Association Between Iodine Nutritional Status and Adverse Pregnancy Outcomes in Beijing, China: a Single-Center Cohort Study

Zhang

Yuan

Sun

et al. 2021

Biol Trace Elem Res

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Iodine is an essential trace element for humans and the main raw material for thyroid hormone synthesis. However, the association between iodine nutritional status and adverse pregnancy outcomes in different regions remains controversial. This single-center cohort study was focused on the association between iodine nutritional status and adverse pregnancy outcomes in Beijing, China. We enrolled 726 pregnant women who were registered at the Peking University International Hospital between February 2017 and December 2019. To analyze the association between iodine nutritional status variations and adverse pregnancy outcomes, this study cohort included 390 (53.72%) participants with iodine deficiency, 206 (28.37%) with an adequate iodine level, 103 (14.19%) with a more than adequate iodine level, and 27 (3.72%) with iodine excess, according to the urinary iodine (UI) status of pregnant women. After adjusting for age, body mass index, parity, and history of spontaneous abortion, we identified iodine deficiency as a risk factor for anti-thyroid peroxidase antibody (TPOAb) positivity [odds ratio (OR), 3.646; 95% confidence interval (95% CI), 1.658–8.017], anti-thyroglobulin antibody (TGAb) positivity (OR, 3.109; 95% CI, 1.465–6.599), and thyroid autoimmunity (OR, 2.885; 95% CI, 1.539–5.407). There was a non-linear relationship between UI and the concentrations of TPOAb and TGAb (Pnon-linear < 0.05). Iodine deficiency during the first trimester is a risk factor for thyroid autoantibody positivity. The relationship between UI and the concentrations of TPOAb and TGAb follows a nearly U-shaped curve. Thus, physicians should critically consider the iodine nutritional status of pregnant women during the first trimester. Clinical Trials.gov Identifier: NCT02966405

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Section: Discussionmentioning

confidence: 99%

Association Between Iodine Nutritional Status and Adverse Pregnancy Outcomes in Beijing, China: a Single-Center Cohort Study

Zhang

Yuan

Sun

et al. 2021

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…The pre-pregnancy body mass index is considered to correlate with the poor pregnancy outcomes [47]. In addition, although iodine deficiency is a common reason for maternal isolated hypothyroxinemia in late pregnancy and a recent study found that our local area had a significant prevalence of iodine deficiency in pregnant women [48,49], we were not able to define the causes of hypothyroxinemia in the present study due to the retrospective study design. Future prospective studies should include the etiology study for maternal isolated hypothyroxinemia.…”

Section: Endocrine Journal Advance Publicationmentioning

confidence: 79%

Association between third trimester maternal isolated hypothyroxinemia and adverse pregnancy outcomes

Chen

Sun

et al. 2023

Endocr J

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To study the effects of third trimester maternal isolated hypothyroxinemia (serum low free thyroxine and normal thyroid stimulating hormone level) on pregnancy outcomes, we performed a retrospective cohort study in women with singleton pregnancy between February 2009 and June 2012. Pregnant women were assigned to two groups, a hypothyroxinemia group (with maternal isolated hypothyroxinemia in the third trimester and normal thyroid function in the first and second trimesters) and a control group (with normal serum thyroid functions). The pregnancy outcomes, including preterm birth, fetal distress, birth weight, premature rupture of membranes, and Apgar score at one minute after the birth, were recorded and compared between the two groups. A total of 3,945 pregnant women (median age 26 year old) were included in the study, with 195 women in the hypothyroxinemia group and 3,750 women in the control group. Compared with the women in the control group, women in the hypothyroxinemia group had higher incidences of premature rupture of membranes and low Apgar score at one minute after the birth. The multivariate logistic regression analysis showed that the low third trimester serum thyroxine level was the independent risk factor for the premature rupture of membranes and low Apgar score. There were no statistically significant differences in preterm birth, macrosomia, and intrauterine fetal distress between two groups. Third trimester maternal isolated hypothyroxinemia was associated with adverse pregnancy outcomes. The maternal serum thyroxine level should be monitored during late pregnancy and necessary management should be applied to improve the pregnancy outcomes.

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“…In addition, only a small percentage of pregnant women (11·3 %) reported the use of iodine supplements (1) . Therefore, these results had provided evidence to support the emergence of mild-to-moderate iodine deficiency in Chinese pregnant women (4,5) . Future studies should investigate the possible barriers regarding the use of iodised salt and/or supplements among pregnant women which were not discussed by the authors (1) .…”

mentioning

confidence: 71%

Mild-to-moderate iodine deficiency in a sample of pregnant women and salt iodine concentration from Zhejiang province, China

Cited by 17 publications

References 37 publications

Association Between Iodine Nutritional Status and Adverse Pregnancy Outcomes in Beijing, China: a Single-Center Cohort Study

Association Between Iodine Nutritional Status and Adverse Pregnancy Outcomes in Beijing, China: a Single-Center Cohort Study

Association between third trimester maternal isolated hypothyroxinemia and adverse pregnancy outcomes

Relationship of household cooking salt and eating out on iodine status of Chinese pregnant women in environmental iodine-deficient coastal areas

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