Mild thyroid hormones deficiency modifies benzodiazepine and mu-opioid receptor binding in rats

Ortiz-Butrón, Rocı́o; Pacheco-Rosado, Jorge; Hernández-García, A.; Briones-Velasco, Magdalena; Rocha, Luísa

doi:10.1016/s0028-3908(02)00372-6

Cited by 16 publications

(10 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hippocampus is more susceptible to damage because it has more NMDA receptors than the amygdala (Newell et al, 2007). In addition, the hippocampus has fewer signals to prevent cellular damage, such as the μ-opioid receptors (Ortiz-Butron et al, 2003) and 5-HT 1A (Lopez-Meraz et al, 2007) than the amygdala.…”

Section: Discussionmentioning

confidence: 99%

Lidocaine affects the redox environment and the antioxidant enzymatic system causing oxidative stress in the hippocampus and amygdala of adult rats

Cano-Europa¹,

Lopez-Galindo²,

Hernández-García³

et al. 2008

Life Sciences

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Lidocaine affects the redox environment and the antioxidant enzymatic system causing oxidative stress in the hippocampus and amygdala of adult rats

Cano-Europa¹,

Lopez-Galindo²,

Hernández-García³

et al. 2008

Life Sciences

View full text Add to dashboard Cite

“…Because it is not known how the lidocaine can cause neuronal damage, though if the lidocaine interacts with these receptors, it is probable that Table 1 Number of neurons in 10 000 μm 2 of the CA3 hippocampal and basolateral amygdala regions of rats treated with one dose of lidocaine, 60 mg/kg or 90 mg/kg the hippocampus suffers more damage than the amygdala. Also, it has been demonstrated that the hippocampus has less μ-opioid receptors (Ortiz-Butron et al, 2003) and 5-HT 1A (Lopez-Meraz et al, 2007) than the amygdala. These changes could also be related to the differences found in the sensitivity between the hippocampus and amygdala.…”

Section: Discussionmentioning

confidence: 99%

Hippocampus and amygdala neurotoxicity produced by systemic lidocaine in adult rats

Blas-Valdivia¹,

Cano-Europa²,

Hernández-García³

et al. 2007

Life Sciences

View full text Add to dashboard Cite

“…This eventually results in anatomical alterations in the cerebellum, cerebrum, hippocampus and other brain structures (Dussault & Ruel, 1987; Porterfield & Hendrich, 1993; Thompson & Potter, 2000; Anderson, 2001; Bernal, 2002; Smith et al 2002; Zoeller & Rovet, 2004). Furthermore, several neurotransmitter systems that play a functional role in activity, mood and learning, hence in behaviour, such as the GABAergic, cholinergic, dopaminergic and serotonergic systems, are altered in hypothyroid rats (Rastogi & Singhai, 1979; Dussault & Ruel, 1987; Darbra et al 1995; Evans et al 1999; Friedhoff et al 2000; Sala‐Roca et al 2002 a ; Smith et al 2002; Broedel et al 2003; Ortiz‐Butron et al 2003; Ausó et al 2004; Friedhoff et al 2000).…”

mentioning

confidence: 99%

Perinatal and chronic hypothyroidism impair behavioural development in male and female rats

Wijk¹,

Rijntjes²,

Heijning³

2008

Experimental Physiology

View full text Add to dashboard Cite

A lack of thyroid hormone, i.e. hypothyroidism, during early development results in multiple morphological and functional alterations in the developing brain. In the present study, behavioural effects of perinatal and chronic hypothyroidism were assessed during development in both male and female offspring of hypothyroid rats. To induce hypothyroidism, dams and offspring were fed an iodide-poor diet and drinking water with 0.75% sodium perchlorate; dams starting 2 weeks prior to mating and pups either until the day of killing (chronic hypothyroidism) or only until weaning (perinatal hypothyroidism) to test for reversibility of the effects observed. Neuromotor competence, locomotor activity and cognitive function were monitored in the offspring until postnatal day 71 and were compared with age-matched control rats. Early neuromotor competence, as assessed in the grip test and balance beam test, was impaired by both chronic and perinatal hypothyroidism. The open field test, assessing locomotor activity, revealed hyperactive locomotor behavioural patterns in chronic hypothyroid animals only. The Morris water maze test, used to assess cognitive performance, showed that chronic hypothyroidism affected spatial memory in a negative manner. In contrast, perinatal hypothyroidism was found to impair spatial memory in female rats only. In general, the effects of chronic hypothyroidism on development were more pronounced than the effects of perinatal hypothyroidism, suggesting the early effects of hypothyroidism on functional alterations of the developing brain to be partly reversible and to depend on developmental timing of the deficiency.

show abstract

Mild thyroid hormones deficiency modifies benzodiazepine and mu-opioid receptor binding in rats

Cited by 16 publications

References 21 publications

Lidocaine affects the redox environment and the antioxidant enzymatic system causing oxidative stress in the hippocampus and amygdala of adult rats

Lidocaine affects the redox environment and the antioxidant enzymatic system causing oxidative stress in the hippocampus and amygdala of adult rats

Hippocampus and amygdala neurotoxicity produced by systemic lidocaine in adult rats

Perinatal and chronic hypothyroidism impair behavioural development in male and female rats

Contact Info

Product

Resources

About