Mild therapeutic hypothermia is associated with favourable outcome in patients after cardiac arrest with non-shockable rhythms

A review of the utility of a hypothermia protocol in cardiac arrests due to non-shockable rhythms

“…This is thought to be due to the fact that more time is needed for full recovery after an acute illness and brain injury [6]. Most of these trials used shortterm outcome measures at the time of discharge or a few months afterward but as noted above, those with longer-term follow up showed intervention to be beneficial [14,17,40]. Analyzing survival and neurologic function over a longer time period might shed light on the utility of TH/TTM in OHCA due to nSR as these patients may derive more benefit in the long-term.…”

Clinical Applications of Targeted Temperature Management

“…6 Multiple subsequent investigations have suggested comatose survivors of nonshockable rhythms may benefi t from TTM as well. [21][22][23][24] Most widely used algorithms for postarrest TTM adhere closely to the protocols used in the two landmark trials but various details are being actively investigated. Animal studies suggest that more rapid induction of TTM after arrest results in better neurologic outcomes.…”

Therapeutic Hypothermia in Cardiac Arrest Survivors

“…While there is good evidence supporting cooling of out-of-hospital adult cardiac arrest patients presenting with ventricular fibrillation, induction in other groups of in-hospital cardiac arrest patients, such as those with non-defibrillating initial rhythm and pediatric patients is supported by lower degrees of evidence (Holzer et al, 2006;Storm et al, 2008;Don et al, 2009;Polderman et al, 2003;Biarent et al, 2010;Testori et al, 2011). Nevertheless, clinical, experimental and patophysiological data suggest that hypothermia may also have protective effects in patients other than those with ventricular fibrillation OHCA.…”