Mild regular treadmill exercise ameliorated the detrimental effects of acute sleep deprivation on spatial memory

Şahin, Leyla; Cevik, Özge Selin; Çevik, Kenan; Güven, Cengiz; Taşkın, Eylem; Kocahan, Sayad

doi:10.1016/j.brainres.2021.147367

Cited by 11 publications

(10 citation statements)

References 66 publications

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“…Although there was an increase in hippocampal BDNF and c‐Fos in SD groups according to our study, this increase was not significant. Similarly, Sahin et al (2021) showed that there was no significant difference between all groups in terms of BDNF and c‐Fos expression levels in RD for 48 h. In line with our findings, Nabaee et al (2018) showed that 24, 48, and 72 h pretraining and 24 post‐training SD did not have any effect on the hippocampal BDNF protein.…”

Section: Discussionsupporting

confidence: 91%

Chronic caffeine consumption improves the acute sleep deprivation‐induced spatial memory impairment while altering N‐methyl‐D‐aspartate receptor subunit expression in male rats

Keloğlan

Şahin

Cevik

2022

Intl J of Devlp Neuroscience

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Caffeine is a psychostimulant substance that is mostly used to prevent fatigue, increase alertness, and ameliorate sleep loss situations. In this study, we aimed to investigate the effect of chronic caffeine consumption on learning and memory functions and related genes in rapid eye movement (REM) sleep‐deprived rats. During the neonatal period (postnatal day [PND] 28) Wistar albino male rats (n = 32) were randomly assigned into four groups: Control (C), caffeine application (Cf), acute REM sleep‐deprivation (RD), and caffeine application + acute RD (Cf + RD). The 48 h of RD was executed when caffeine administration was completed. The learning and memory performance was evaluated by the Morris water maze test (MWMT). Following this, the rats were decapitated to isolate hippocampus tissues. In MWMT, time spent in the targeted quadrant decreased significantly in the RD group compared with the C and Cf + RD group. NR2A expression level increased in the RD group compared with C, Cf, and Cf + RD groups (p < 0.05). NR2B expression level increased in RD and Cf + RD groups compared with C and Cf groups (p < 0.05). BDNF and c‐Fos expression levels did not differ significantly between the groups. RD impaired hippocampal spatial memory performance in the MWMT test. Our results indicated that chronic caffeine consumption has a therapeutic effect on spatial memory deterioration impairment caused by RD. Furthermore, it seems that the effect of caffeine RD on the hippocampus may be mediated by NR2A.

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Section: Discussionsupporting

confidence: 91%

Chronic caffeine consumption improves the acute sleep deprivation‐induced spatial memory impairment while altering N‐methyl‐D‐aspartate receptor subunit expression in male rats

Keloğlan

Şahin

Cevik

2022

Intl J of Devlp Neuroscience

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“…This question was recently addressed in a series of animal studies, which investigated the protective effects of chronic exercise in reducing memory impairments induced with sleep deprivation protocols targeting REM sleep and, possibly to a lesser extent, other phases of sleep (9,10,12,14,36,51–58) (Table). Taken together, the results of these studies demonstrated that exposing rodents to voluntary or forced treadmill-based cardiovascular training for some weeks protected memory from the deleterious effects of an acute episode (12–96 h) of sleep deprivation.…”

Section: Does Exercise Protect Memory Against Sleep Deprivation?mentioning

confidence: 99%

Exercising the Sleepy-ing Brain: Exercise, Sleep, and Sleep Loss on Memory

Roig

Cristini

Parwanta

et al. 2022

Exercise and Sport Sciences Reviews

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“…Overall, only a limited number of studies (11.1%, n = 6/54) reported a lack of significant changes in any of the evaluated parameters compared to their respective control group [ 26 , 27 , 28 , 29 , 30 , 31 ]. Conversely, the overwhelming majority of results point to either increases or decreases in at least one parameter associated with oxidative stress.…”

Section: Resultsmentioning

confidence: 99%

“…With a few exceptions [ 26 , 27 , 28 , 29 , 30 , 31 ], most studies included in our review revealed changes in at least one parameter associated with oxidative stress in both PSD and TSD protocols. Even when taking only lipid peroxidation into consideration, with some exceptions [ 26 , 27 , 28 , 29 , 31 , 44 , 53 , 54 , 55 , 57 , 58 ], most studies that determined this parameter revealed elevated levels of lipid peroxidation in both PSD and TSD protocols.…”

Section: Discussionmentioning

confidence: 99%

Sleep Deprivation-Induced Oxidative Stress in Rat Models: A Scoping Systematic Review

et al. 2023

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Sleep deprivation is highly prevalent in the modern world, possibly reaching epidemic proportions. While multiple theories regarding the roles of sleep exist (inactivity, energy conservation, restoration, brain plasticity and antioxidant), multiple unknowns still remain regarding the proposed antioxidant roles of sleep. The existing experimental evidence is often contradicting, with studies pointing both toward and against the presence of oxidative stress after sleep deprivation. The main goals of this review were to analyze the existing experimental data regarding the relationship between sleep deprivation and oxidative stress, to attempt to further clarify multiple aspects surrounding this relationship and to identify current knowledge gaps. Systematic searches were conducted in three major online databases for experimental studies performed on rat models with oxidative stress measurements, published between 2015 and 2022. A total of 54 studies were included in the review. Most results seem to point to changes in oxidative stress parameters after sleep deprivation, further suggesting an antioxidant role of sleep. Alterations in these parameters were observed in both paradoxical and total sleep deprivation protocols and in multiple rat strains. Furthermore, the effects of sleep deprivation seem to extend beyond the central nervous system, affecting multiple other body sites in the periphery. Sleep recovery seems to be characterized by an increased variability, with the presence of both normalizations in some parameters and long-lasting changes after sleep deprivation. Surprisingly, most studies revealed the presence of a stress response following sleep deprivation. However, the origin and the impact of the stress response during sleep deprivation remain somewhat unclear. While a definitive exclusion of the influence of the sleep deprivation protocol on the stress response is not possible, the available data seem to suggest that the observed stress response may be determined by sleep deprivation itself as opposed to the experimental conditions. Due to this fact, the observed oxidative changes could be attributed directly to sleep deprivation.

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Mild regular treadmill exercise ameliorated the detrimental effects of acute sleep deprivation on spatial memory

Cited by 11 publications

References 66 publications

Chronic caffeine consumption improves the acute sleep deprivation‐induced spatial memory impairment while altering N‐methyl‐D‐aspartate receptor subunit expression in male rats

Chronic caffeine consumption improves the acute sleep deprivation‐induced spatial memory impairment while altering N‐methyl‐D‐aspartate receptor subunit expression in male rats

Exercising the Sleepy-ing Brain: Exercise, Sleep, and Sleep Loss on Memory

Sleep Deprivation-Induced Oxidative Stress in Rat Models: A Scoping Systematic Review

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