2011
DOI: 10.1210/jc.2011-0238
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Mild Primary Hyperparathyroidism: Vitamin D Deficiency and Cardiovascular Risk Markers

Abstract: Except for a lower 25-OH-D level and slightly higher systolic BP and TG levels, patients with mild PHPT without other CV risk factors did not differ from healthy controls as regards biomarkers predicting CV diseases. PTX had an overall positive effect on TG level, BP, and vitamin D status.

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Cited by 60 publications
(59 citation statements)
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“…Considering mild PHPT patients, an increased insulin resistance (HOMA IR) and lower quantitative insulin sensitivity check index (QUICKI) compared to controls, has been reported by some investigators (54); however, these findings were not confirmed by Gianotti et al (56). PTx in patients with mild PHPT showed no improvement in insulin sensitivity after one year (57,58,59) or 2 years (41). In patients with asymptomatic PHPT, a conservative follow-up of 18 months showed no progression of calcium and glucose metabolism abnormalities (60).…”
Section: Glucose Metabolismmentioning
confidence: 96%
See 1 more Smart Citation
“…Considering mild PHPT patients, an increased insulin resistance (HOMA IR) and lower quantitative insulin sensitivity check index (QUICKI) compared to controls, has been reported by some investigators (54); however, these findings were not confirmed by Gianotti et al (56). PTx in patients with mild PHPT showed no improvement in insulin sensitivity after one year (57,58,59) or 2 years (41). In patients with asymptomatic PHPT, a conservative follow-up of 18 months showed no progression of calcium and glucose metabolism abnormalities (60).…”
Section: Glucose Metabolismmentioning
confidence: 96%
“…Limited data exist on the effect of PTx on blood pressure in patients with mild PHPT; blood pressure was reduced one year after surgical intervention in one study (38) while it remained stable after 6 months in another investigation (39,40). It should be noted that the only randomized two-year duration study in mild PHPT patients showed neither benefit after PTx nor a deleterious effect on blood pressure with conservative management (41).…”
Section: Hypertensionmentioning
confidence: 99%
“…Also, we used an echo machine HP 5500, which has a better resolution. In a recent study by Farahnak et al, 21,22 they concluded that mild HPT patients did not differ from healthy controls for cardiovascular risk and observed no differences in systolic or diastolic functions or in cardiac morphology between the PHPT patients and the age-matched healthy controls. At baseline, the level of 25-OHD was significantly lower in patients in comparison with controls (40.1 ± 16.5), but still very high from our patients.…”
Section: Discussionmentioning
confidence: 94%
“…Higher serum 25(OH)D concentrations increase the absorption of intestinal calcium, which may bind to fatty and bile acids and form insoluble lipid-calcium complexes, thereby inhibiting the absorption of cholesterol and increasing fecal excretion [36]. Elevated PTH levels associated with low serum 25(OH)D concentrations may also account for this association, because higher triglycerides levels has also been observed in states of hyperparathyroidism [37].…”
Section: Discussionmentioning
confidence: 99%