Mild prenatal stress enhances learning performance in the non-adopted rat offspring

Fujioka, Takashi; Fujioka, Aya; Tan, Nobusuke; Chowdhury, Golam M. I.; Mouri, Hisatsugu; Sakata, Yoshiyuki; Nakamura, Shôji

doi:10.1016/s0306-4522(00)00582-0

Cited by 120 publications

(73 citation statements)

References 36 publications

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“…Early stress results in changes in emotionality of offspring and affects learning rates in adult rats. Mild prenatal stress of the mother will result in offspring with reduced fear reactions and increased learning rates (Fujioka et al, 2001). Increased levels of prenatal stress may produce a reversed pattern (Lehman, Stohr, & Feldon, 2000).…”

Section: Discussionmentioning

confidence: 99%

Do Rats Show a Mozart Effect?

Steele

2003

Music Perception

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The "Mozart effect" is an increase in spatial reasoning scores after listening to a Mozart piano sonata. Both the production and interpretation of the effect are controversial. Many studies have failed to replicate the original effect. Other studies have explained a Mozart effect as being caused by changes in arousal or differences in preferences of the listener. F. H. Rauscher, K. D. Robinson, and J. J. Jens (1998) reported that rats learned to complete a T-maze more quickly if they had been exposed in utero and reared hearing a Mozart piano sonata. They concluded that the result indicated a direct effect of the music on brain development and contradicted competing accounts of arousal or preference. This article is an analysis of the experiment by Rauscher et al. The in utero exposure would have been ineffective because rats are born deaf. A comparison of human and rat audiograms, in the context of the frequencies produced by a piano, suggests that adult rats are deaf to most notes in the sonata. The successful performance of the Mozart group may be explained by the incomplete use of random assignment of subjects to groups and by experimenter effects in the construction of groups. The results of do not provide strong support for the existence of the Mozart effect.

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Section: Discussionmentioning

confidence: 99%

Do Rats Show a Mozart Effect?

Steele

2003

Music Perception

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“…While prolonged stress slows the acquisition of spatial learning in the Morris water maze; 50-52 milder forms of stress do not impair the learning performance 53 or affect that only in males 54,55 or even cause a faster rate of learning performance. 14,56 Offspring of prenatally stressed rats have also demonstrated lesser cognitive performance in other learning tests, such as spontaneous alteration or exploration in the Y-maze, delayed alternation in the T-maze, passive avoidance conditioning and radial arm maze performance.…”

Section: Effects Of Maternal Stress On the Developing Nervous Systemmentioning

confidence: 99%

Effects of prenatal stress on developmental anatomy of the brain and adult behavioural pathology

Ulupinar¹

2009

Anatomy

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Perinatal period is a time of particular vulnerability to stress which has serious consequences on the developing foetus through both maternal behaviours and physiological changes. Such distress can result from natural or man-made disasters such as earthquakes, floods, storms, war or terrorist acts. Besides, not only in socio-economically disadvantaged regions with less educated background and high unemployment rates, but also in every civilized society; pregnant women are exposed to intimate partner and patriarchal family violence, as well as interpersonal tensions or adverse conditions in the workplace.1 Moreover, pregnancy related risk factors and dramatic fluctuations in gonadal hormone levels increase the prevalence of mood disorders and anxiety symptoms during this period. 2-4 Regardless of its nature and origin, stressful situations are considered as a 'threat to homeostasis' and a series of morphological, physiological and behavioural responses occur to restore the original condition. 5 Unfortunately, these responses negatively affect the rate of development, mental and physical health of the offspring and increase the incidence of preterm birth, lower birth weights and smaller head circumferences.6-8In turn, less optimal birth outcomes can lead to longterm cognitive impairments and motor disabilities.There is also compelling evidence showing that stress exposure during prenatal life enhances susceptibility for emotional problems and behavioural disorders later in Effects of prenatal stress on developmental anatomy of the brain and adult behavioural pathology Emel Ulup›nar Department of Anatomy, Faculty of Medicine, Eskiflehir Osmangazi University, Turkey AbstractDuring critical or sensitive periods of development, the brain is highly plastic and particularly vulnerable to environmental adverse effects, including stress. In response to gestational stress, activation of the sympathetic system, the HPA axis and the central limbic stress loop increase the level of circulating glucocorticoids and catecholamines in both mother and foetus. Exposure to the excess amount of corticosteroids permanently reduces the glucocorticoid and mineralocorticoid receptors; thereby leading to an attenuation of the HPA axis feedback sensitivity and enhanced responsiveness to stress in the adult offspring. In the assessment of consequences at the behavioural, functional, and morphological levels; experimental animal models of maternal stress are extremely useful, in which the timing, intensity and duration of stress exposure can be readily controlled. These animal studies have revealed important links between prenatal stress exposure, life-long changes in the HPA function, and enhanced risk for subsequent psychopathology in a sex-specific manner. The aim of this review is to examine the impacts of prenatal stress on developmental anatomy of the brain, particularly focusing on the relevant emotional and behavioural outcomes within the context of current data obtained from experimental animals.

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“…Changes in brain structure and function of prenatally stressed animals have also been documented (Welberg & Seckl,2001). Yet not all documented effects of prenatal stress are negative mild stress has been observed to benefit, not damage, later learning in rats (Fujioka et al, 2001). …”

Section: Introductionmentioning

confidence: 99%

A Study on Assessment of Health, Cognitive Behavior and Nutritional Status of Pregnant Women

2016

IJSR

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Abstract:The objective of the present study is to evaluate the Nutritional status and cognitive behavior, mental disorders of the pregnant women. For the purpose of study 40 pregnant women were selected. The age between 22-36 Years and the samples was collected from Govt. General hospital, Guntur District, Andhra Pradesh, India. Hemoglobin levels collected by Shahlis hemometer. Hemoglobin levels of pregnant women were below the standards. Nutrient intakes were collected by using 24 hrs recall method. The present study reveals that there were lower consumption in several macro and micro nutrients intake compared to Recommended Dietary Allowances (RDA) of India, which may be reflected on their nutritional status. Cognitive behavior and Psychological aspects of the pregnant women, not only those aspects but also it reflects on their health conditions.

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Mild prenatal stress enhances learning performance in the non-adopted rat offspring

Cited by 120 publications

References 36 publications

Do Rats Show a Mozart Effect?

Do Rats Show a Mozart Effect?

Effects of prenatal stress on developmental anatomy of the brain and adult behavioural pathology

A Study on Assessment of Health, Cognitive Behavior and Nutritional Status of Pregnant Women

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