Mild photothermal therapy assist in promoting bone repair: Related mechanism and materials

Yu, Zehao; Wang, Hao; Ying, Boda; Mei, Xiaohan; Zeng, Dapeng; Liu, Shibo; Qu, Wenrui; Pan, Xiangjun; Pu, Si; Li, Ruiyan; Qin, Yanguo

doi:10.1016/j.mtbio.2023.100834

Cited by 7 publications

(5 citation statements)

References 176 publications

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“…Converting light energy into heat to induce localized hyperthermia and maintaining a controlled temperature of hyperthermia around 40–42 °C is proposed to be beneficial for bone regeneration . This mild hyperthermia has been shown to stimulate various cellular processes involved in osteogenesis, including enhanced cell proliferation, differentiation, and extracellular matrix deposition . Moreover, this can promote angiogenesis and improve the delivery of nutrients and oxygen to the site of bone injury, facilitating accelerated tissue regeneration .…”

Section: Resultsmentioning

confidence: 99%

“…2 This mild hyperthermia has been shown to stimulate various cellular processes involved in osteogenesis, including enhanced cell proliferation, differentiation, and extracellular matrix deposition. 56 Moreover, this can promote angiogenesis and improve the delivery of nutrients and oxygen to the site of bone injury, facilitating accelerated tissue regeneration. 56 Our research demonstrated that the GH-BZ hydrogel exhibited optimal PTT effects under NIR radiation, significantly enhancing the expression of genes and proteins associated with osteogenesis.…”

Section: In Vitro Osteogenic Differentiationmentioning

confidence: 99%

“…56 Moreover, this can promote angiogenesis and improve the delivery of nutrients and oxygen to the site of bone injury, facilitating accelerated tissue regeneration. 56 Our research demonstrated that the GH-BZ hydrogel exhibited optimal PTT effects under NIR radiation, significantly enhancing the expression of genes and proteins associated with osteogenesis. However, current research predominantly reports that the mechanism whereby PTT facilitates bone regeneration may involve the increased activities of ALP and HSPs, 17,57 and this will be evaluated in future research.…”

Section: In Vitro Osteogenic Differentiationmentioning

confidence: 99%

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ZIF-8-Modified Black Phosphorus Nanosheets Incorporated into Injectable Dual-Component Hydrogels for Enhanced Photothermal Antibacterial and Osteogenic Activities

Li,

Wang,

Xue

et al. 2024

ACS Appl. Mater. Interfaces

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Section: Resultsmentioning

confidence: 99%

Section: In Vitro Osteogenic Differentiationmentioning

confidence: 99%

Section: In Vitro Osteogenic Differentiationmentioning

confidence: 99%

See 1 more Smart Citation

ZIF-8-Modified Black Phosphorus Nanosheets Incorporated into Injectable Dual-Component Hydrogels for Enhanced Photothermal Antibacterial and Osteogenic Activities

Li,

Wang,

Xue

et al. 2024

ACS Appl. Mater. Interfaces

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“…This indicates that the impact of weather on KOA is not just a psychological or mental "illusion". Therapies and treatment targets related to temperature are worthy of further attention [27].…”

Section: Discussionmentioning

confidence: 99%

Meteorological Influence as an Exacerbating Factor in Knee Osteoarthritis: A Prospective Longitudinal Study

shen,

Xu,

Jiang

et al. 2024

Preprint

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Background Osteoarthritis (OA) is a primary cause of disability among the elderly, and its pathogenesis is unclear. This study explores the correlations of different meteorological factors to characteristics and outcomes of knee osteoarthritis (KOA) patients through a 2-year follow-up. Methods The study enrolled 70 participants with KOA from Shanghai, China and conducted a follow-up assessment 2 years later. Assessment parameters included knee pain score, bone marrow abnormality (BMA) score, and levels of proinflammatory cytokine interleukin-1β (IL-1β) and IL-6. Additionally, meteorological data on temperature, wind speed, and relative humidity were collected from local meteorological stations. At baseline, meteorological factors were discretized into binary variables using their respective median values. The analysis of the associations between these meteorological factors and pain scores, BMA scores, and proinflammatory cytokines levels were conducted through the Mann-Whitney U test. Longitudinally, the associations between these meteorological factors and the mentioned KOA indicators were determined using multivariate linear regression models. Results At baseline, the average age of individuals is 60.6 years old. In the low temperature group individuals had higher WOMAC pain scores (p = 0.022), increased levels of IL-1β (p < 0.001) and IL-6 (p = 0.047) compared to those in the high temperature group. In longitudinal analysis, there were notable associations between temperature fluctuations and alterations in the pain scores (β=-0.916, p < 0.001), IL-1β (β=-0.859, p < 0.001) and IL-6 levels (β=-0.577, p = 0.006). Conclusion These findings provide evidence that temperature has a significant impact on the pain and inflammatory levels in patients with KOA. Conversely, wind speed and relative humidity do not exhibit such effects.

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“…The repair of damaged bones is intricate and involves the complex interplay between bone cells, extracellular components, and osteoinductive factors ( Lin X. et al, 2020 ; Kosinski et al, 2020 ; Zhou B. et al, 2023 ; Yu et al, 2023 ). Therefore, the regeneration and repair of bone defects require an appropriate temperature.…”

Section: Application Of Photothermal Hydrogels In Infection Control A...mentioning

confidence: 99%

Photothermal hydrogels for infection control and tissue regeneration

Sun,

Jiang,

Dong

et al. 2024

Front. Bioeng. Biotechnol.

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In this review, we report investigating photothermal hydrogels, innovative biomedical materials designed for infection control and tissue regeneration. These hydrogels exhibit responsiveness to near-infrared (NIR) stimulation, altering their structure and properties, which is pivotal for medical applications. Photothermal hydrogels have emerged as a significant advancement in medical materials, harnessing photothermal agents (PTAs) to respond to NIR light. This responsiveness is crucial for controlling infections and promoting tissue healing. We discuss three construction methods for preparing photothermal hydrogels, emphasizing their design and synthesis, which incorporate PTAs to achieve the desired photothermal effects. The application of these hydrogels demonstrates enhanced infection control and tissue regeneration, supported by their unique photothermal properties. Although research progress in photothermal hydrogels is promising, challenges remain. We address these issues and explore future directions to enhance their therapeutic potential.

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Mild photothermal therapy assist in promoting bone repair: Related mechanism and materials

Cited by 7 publications

References 176 publications

ZIF-8-Modified Black Phosphorus Nanosheets Incorporated into Injectable Dual-Component Hydrogels for Enhanced Photothermal Antibacterial and Osteogenic Activities

ZIF-8-Modified Black Phosphorus Nanosheets Incorporated into Injectable Dual-Component Hydrogels for Enhanced Photothermal Antibacterial and Osteogenic Activities

Meteorological Influence as an Exacerbating Factor in Knee Osteoarthritis: A Prospective Longitudinal Study

Photothermal hydrogels for infection control and tissue regeneration

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