Mild periconceptional hyperglycemia: predictor of adverse fetomaternal outcomes in gestational diabetes?

Saraiva, Miguel Mascarenhas; Fonseca, Liliana; Santos, Tiago da Silva; Vilaverde, Joana; Pereira, Maria Teresa; Pichel, Fernando; Pinto, Clara; Almeida, Margarida; Dores, Jorge

doi:10.1007/s00592-021-01714-w

Cited by 3 publications

(4 citation statements)

References 24 publications

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“…This may be related to the heterogeneity in diagnostic criteria for early-onset GDM and different time definitions and sample sizes. A large retrospective cohort study in Portugal including 18,518 pregnant women with GDM reported that the incidence of early-onset GDM (≤ 12 weeks) was 34.4% according to the IADPSG diagnostic criteria; there was no difference in the incidence of PE between women with early- and later-onset GDM ( 74 ). Furthermore, several studies have reported the same conclusion ( 55 , 75 – 79 ).…”

Section: Factors Associated With Occurrence Of Pe In Women With Gdmmentioning

confidence: 99%

Gestational Diabetes Mellitus and Preeclampsia: Correlation and Influencing Factors

Yang

2022

Front. Cardiovasc. Med.

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Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common pregnancy complications with similar risk factors and pathophysiological changes. Evidence from previous studies suggests that the incidence of PE is significantly increased in women with GDM, but whether GDM is independently related to the occurrence of PE has remained controversial. GDM complicated by PE further increases perinatal adverse events with greater impact on the future maternal and offspring health. Identify factors associated with PE in women with GDM women, specifically those that are controllable, is important for improving pregnancy outcomes. This paper provides the findings of a review on the correlation between GDM and PE, factors associated with PE in women with GDM, possible mechanisms, and predictive markers. Most studies concluded that GDM is independently associated with PE in singleton pregnancy, and optimizing the treatment and management of GDM can reduce the incidence of PE, which is very helpful to improve pregnancy outcomes.

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Section: Factors Associated With Occurrence Of Pe In Women With Gdmmentioning

confidence: 99%

Gestational Diabetes Mellitus and Preeclampsia: Correlation and Influencing Factors

Yang

2022

Front. Cardiovasc. Med.

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“…Several other studies have shown an association between LGA and macrosomia with elevation in first-trimester FPG [ 36 , 41 , 46 , 47 , 48 , 49 ]. A higher FPG was also associated with pregnancy-induced hypertension (PIH) [ 36 , 46 , 48 ], prematurity and preterm birth [ 46 , 48 ], non-evolutive pregnancies and fetal death [ 50 ], CS and assisted vaginal delivery [ 41 ], and neonatal intensive care unit (NICU) admission [ 51 ]. An interesting observation was the higher risk of fetal complications arising from elevated FPG levels irrespective of subsequent GDM [ 48 , 51 ].…”

Section: Fasting Plasma Glucose For Diagnosis Of Egdmmentioning

confidence: 99%

“…First-trimester FPG ≥ 92 mg/dL (5.1 mmol/L), as well as 100.8 mg/dL (5.6 mmol/L), indicate a higher risk of macrosomia, LGA, non-evolutive pregnancies, fetal death, PIH, and NICU admissions [ 36 , 48 , 49 , 50 , 51 ]. In a recently published large retrospective study analyzing 22,398 singleton pregnancies, FPG ≥ 92 mg/dL (5.1 mmol/L) and a normal OGTT between 24 and 28 weeks had a similar pregnancy outcome as cGDM [ 48 ].…”

Section: Fasting Plasma Glucose For Diagnosis Of Egdmmentioning

confidence: 99%

Early Gestational Diabetes Mellitus: Diagnostic Strategies and Clinical Implications

et al. 2021

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Preexisting diabetes mellitus (DM) should be ruled out early in pregnancy in those at risk. During screening, a significant proportion of women do not reach the threshold for overt DM but fulfill the criteria used for diagnosing conventional gestational DM (cGDM). There is no consensus on the management of pregnancies with intermediate levels of hyperglycemia thus diagnosed. We have used the term early gestational DM (eGDM) for this condition and reviewed the currently available literature. Fasting plasma glucose (FPG), oral glucose tolerance test, and glycated hemoglobin (HbA1c) are the commonly employed screening tools in early pregnancy. Observational studies suggest that early pregnancy FPG and Hba1c correlate with the risk of cGDM and adverse perinatal outcomes. However, specific cut-offs, including those proposed by the International Association of the Diabetes and Pregnancy Study Group, do not reliably predict the development of cGDM. Emerging data, though indicate that FPG ≥ 92 mg/dL (5.1 mmol/L), even in the absence of cGDM, signals the risk for perinatal complication. Elevated HbA1c, especially a level ≥ 5.9%, also correlates with the risk of cGDM and worsened outcome. HbA1c as a diagnostic test is however besieged with the usual caveats that occur in pregnancy. The studies that explored the effects of intervention present conflicting results, including a possibility of fetal malnutrition and small-for-date baby in the early treatment group. Diagnostic thresholds and glycemic targets in eGDM may differ, and large multicenter randomized controlled trials are necessary to define the appropriate strategy.

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“…The incidence of GDM in China is 11.91%, and the incidence is on the rise (3). Women with GDM are at increased risk of developing gestational hypertension and preeclampsia, and are more likely to experience GDM recurrence in future pregnancies (4)(5)(6). GDM is associated with an increased risk of type 2 diabetes (T2D) and cardiovascular disease in mothers and offspring.…”

Section: Introductionmentioning

confidence: 99%

miR-199a Is Upregulated in GDM Targeting the MeCP2-Trpc3 Pathway

et al. 2022

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Gestational diabetes mellitus (GDM), the most common medical pregnancy complication, has become a growing problem. More and more studies have shown that microRNAs are closely related to metabolic processes. The purpose of this paper is to investigate the role of up-regulation of miR-199a-5p expression in GDM. We found that miR-199a-5p was significantly up-regulated in the placenta of GDM patients compared with normal pregnant women, and expressed in placental villi. miR-199a-5p can regulate the glucose pathway by inhibiting the expression of methyl CpG-binding protein 2 (MeCP2) and down-regulating canonical transient receptor potential 3 (Trpc3). This suggests that miR-199a-5p may regulate the glucose pathway by regulating methylation levels, leading to the occurrence of GDM.

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Mild periconceptional hyperglycemia: predictor of adverse fetomaternal outcomes in gestational diabetes?

Cited by 3 publications

References 24 publications

Gestational Diabetes Mellitus and Preeclampsia: Correlation and Influencing Factors

Gestational Diabetes Mellitus and Preeclampsia: Correlation and Influencing Factors

Early Gestational Diabetes Mellitus: Diagnostic Strategies and Clinical Implications

miR-199a Is Upregulated in GDM Targeting the MeCP2-Trpc3 Pathway

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