Mild oxidative stress protects against chemotherapy-induced hair loss

Abstract

Chemotherapy induces hair loss in most cancer patients who undergo treatment, which causes them significant psychosocial trauma. Scalp cooling has demonstrated some efficacy in attenuating chemotherapy-induced alopecia, but response rate varies between patients and chemotherapy class. Here, we showcase in rats a proof-of-concept treatment of using subcutaneous hydrogen peroxide and cumene hydroperoxide injections to provide total protection from hair loss against multiple classes of chemotherapy. We found that subcutaneous peroxides induce cell cycle arrest via P53 activation, thereby protecting hair follicles from the cytotoxic effects of chemotherapy on actively dividing cells. This treatment represents a highly effective and accessible way for cancer patients to maintain quality of life while undergoing treatment for cancer.

Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study

“…Earlier research demonstrated that oxidative stress triggers the activation of the P53 pathway, inducing cell cycle arrest in the hair follicles and skin. [14] In order to sustain intracellular balance, antioxidants must regulate prooxidant activity, employing 4 lines of defense. [15][16][17] The primary defense against imbalance involves antioxidant enzymes, aimed at preventing free radical formation and neutralizing existing radicals.…”