Mild elevation of urinary biomarkers in prerenal acute kidney injury

Doi, Kent; Katagiri, Daisuke; Negishi, Kousuke; Hasegawa, Shin; Hamasaki, Yoshifumi; Fujita, Toshiro; Matsubara, Takehiro; Ishii, Takeshi; Yahagi, Naoki; Sugaya, Takeshi; Noiri, Eisei

doi:10.1038/ki.2012.266

Cited by 84 publications

(79 citation statements)

References 33 publications

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“…Nejat et al 28 analyzed data from 489 ICU patients and found that uNGAL levels were not significantly increased in pre-renal AKI compared with patients with no-AKI. In contrast, Doi et al 29 found that uNGAL in patients with pre-renal AKI showed modest, but significantly higher concentrations than in patients with non-AKI. Recently, we undertook a prospective observational study, including 100 critically ill patients, in order to compare the ability of four renal biomarkers [pNGAL, uNGAL, plasma CysC (pCysC), and sCr] to predict early AKI.…”

Section: Ngal In the General Adult Icumentioning

confidence: 91%

“…According to Doi et al 22 the AUCs of uIL-18 for AKI prediction within 1 week after admission and prediction of death 14 days post-entry were 0.69 and 0.83, respectively. In another study by Doi et al, 29 uIL-18 in patients with pre-renal AKI showed modest but significantly higher concentrations than in patients with non-AKI.…”

Section: Interleukin-18mentioning

confidence: 99%

“…Another study found that uL-FABP in patients with pre-renal AKI showed modest, but significantly higher concentrations than in patients with non-AKI. 29 Kidney Injury Molecule-1 KIM-1 is a transmembrane protein that is overexpressed in dedifferentiated proximal tubule cells after ischemic or nephrotoxic AKI in animal models, 59 and a proteolytically processed domain is easily detected in the urine (Table 4). 60 The presence of KIM-1 has been demonstrated in renal biopsy specimens of patients with proven acute tubular necrosis.…”

Section: Interleukin-18mentioning

confidence: 99%

“…Another study found that uNAG in patients with pre-renal AKI showed modest, but significantly higher concentrations than in patients with non-AKI. 29 Other Kidney Biomarkers Some urine proteins (particularly enzymes) released from damaged tubular cells have been used as AKI biomarkers (Table 5). Increased urine excretion of these proteins implies cellular necrosis.…”

Section: Kim-1 In the General Adult Icumentioning

confidence: 99%

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Novel Biomarkers of Acute Kidney Injury in the General Adult ICU: A Review

et al. 2013

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Acute kidney injury is one of the most frequent problems occurring in the critically ill patients of the intensive care units and it is well established that it increases both morbidity and mortality in these patients. Moreover, despite technological and pharmaceutical advances during the last decades, the incidence as well as the mortality associated with acute kidney injury in these patients remains unchanged. Creatinine, the most common renal dysfunction biomarker in use, has many disadvantages, such as time delay in its increase and the influence by other factors on its serum concentration, such as age, gender, muscle mass, etc. Hence, the need for better renal biomarkers in order to timely intervene for acute kidney injury prevention is imperative. The lack of an early biomarker is an obstacle for the development of new acute kidney injury prevention strategies. With the incidence of acute kidney injury reaching epidemic dimensions, the need for novel markers is urgent. During the last years, the research for finding such biomarkers has been intense. The purpose of the present article is to review the studies which have tested the predictive ability of those markers (in urine and/or plasma) for early detection of acute kidney injury in the mixed adult intensive care unit population and underline the potential limitations encountered in the various studies.

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Section: Ngal In the General Adult Icumentioning

confidence: 91%

Section: Interleukin-18mentioning

confidence: 99%

Section: Interleukin-18mentioning

confidence: 99%

Section: Kim-1 In the General Adult Icumentioning

confidence: 99%

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Novel Biomarkers of Acute Kidney Injury in the General Adult ICU: A Review

et al. 2013

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“…Some of these factors have been considered in previous studies (Doi et al 2012;Jin et al 2012;Li et al 2012), such as gender, age, daily activity and environmental factors. However, some factors, especially medication, are difficult to control because during the collection of urine, the regular therapeutic process of patients should not be disturbed.…”

Section: Introductionmentioning

confidence: 99%

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Biomarker is the measurable change associated with a physiological or pathophysiological process.Unlike blood which has mechanisms to keep the internal environment homeostatic, urine is more likely to reflect changes of the body. In other words, urine is likely to be a better biomarker source than blood. However, the urinary proteome are affected by many factors. In this study, the effects of three commonly used diuretics (furosemide, hydrochlorothiazide and spirolactone ) on the urinary proteome were analyzed in rats. Urine samples were collected before and after the intragastric administration of diuretics at therapeutic doses and analyzed using LC-MS/MS. Based on quantification by Progenesis LC-MS software, there are 7, 5 and 2 proteins with the p value ≤0.05, a fold change ≥2, a spectral count ≥5 and FDR ≤1%, respectively. Most their human orthologs were considered to be stable in the healthy human urinary proteome. 10 of the 14 proteins have been reported as disease biomarkers in previous studies. So the effects of diuretics should be given more attention in future urinary protein biomarkers studies. The effects of diuretics on urinary proteome are different which can provide clues to elucidate the mechanisms of the diuretics. IntroductionBiomarker is the measurable change associated with a physiological or pathophysiological process. Unlike blood which has mechanisms to keep the internal environment homeostatic, urine is more likely to reflect changes of the body. In other words, urine is likely to be a better biomarker source than blood. However, the urinary proteome are affected by many factors. In this study, the effects of three commonly used diuretics (furosemide, hydrochlorothiazide and spirolactone) on the urinary proteome were analyzed in rats. Urine samples were collected before and after the intragastric administration of diuretics at therapeutic doses and analyzed using LC-MS/MS. Based on quantification by Progenesis LC-MS software, there are 7, 5 and 2proteins with the p value ≤0.05, a fold change ≥2, a spectral count ≥5 and FDR ≤1%, respectively. Most their human orthologs were considered to be stable in the healthy human urinary proteome. 10 of the 14 proteins have been reported as disease biomarkers in previous studies. So the effects of diuretics should be given more attention in future urinary protein biomarkers studies. The effects of diuretics on urinary proteome are different which can provide clues to elucidate the mechanisms of the diuretics.

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