Mild dehydration, vasopressin and the kidney: animal and human studies

Bouby, Nadine; Fernandes, Sarah

doi:10.1038/sj.ejcn.1601900

Cited by 56 publications

(50 citation statements)

References 40 publications

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“…However others experiments have shown that the threshold for both thirst and ADH secretion are near the same [25]. These differences can be explained by inter-individual genetic variability among people [26]. In instances where ADH secretion is maximal and fluid intake does not suffice to maintain plasma osmolality, physiological thirst kicks in at the higher levels of plasma osmolality.…”

Section: Osmolal Regulationmentioning

confidence: 99%

Diabetes Insipidus: A Review

Shapiro¹

2013

J Diabetes Metab

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Section: Osmolal Regulationmentioning

confidence: 99%

Diabetes Insipidus: A Review

Shapiro¹

2013

J Diabetes Metab

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“…A potent renal vasopressin receptor agonist, dDAVP, markedly reduced both urine flow and sodium excretion in healthy humans [51]. The impact of antinatriuresis by chronic high vasopressin levels in mild dehydration on the pathophysiology of hypertension, however, needs to be delineated.…”

Section: Hypertensionmentioning

confidence: 99%

Hydration and Disease

Manz

2007

Journal of the American College of Nutrition

101

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Many diseases have multifactorial origins. There is increasing evidence that mild dehydration plays a role in the development of various morbidities. In this review, effects of hydration status on acute and chronic diseases are depicted (excluding the acute effects of mild dehydration on exercise performance, wellness, cognitive function, and mental performance) and categorized according to four categories of evidence (I-IV). Avoidance of a high fluid intake as a precautionary measure may be indicated in patients with cardiovascular disorders, pronounced chronic renal failure (III), hypoalbuminemia, endocrinopathies, or in tumor patients with cisplatin therapy (IIb) and menace of water intoxication. Acute systemic mild hypohydration or dehydration may be a pathogenic factor in oligohydramnios (IIa), prolonged labor (IIa), cystic fibrosis (III), hypertonic dehydration (III), and renal toxicity of xenobiotica (Ib). Maintaining good hydration status has been shown to positively affect urolithiasis (Ib) and may be beneficial in treating urinary tract infection (IIb), constipation (III), hypertension (III), venous thromboembolism (III), fatal coronary heart disease (III), stroke (III), dental disease (IV), hyperosmolar hyperglycemic diabetic ketoacidosis (IIb), gallstone disease (III), mitral valve prolapse (IIb), and glaucoma (III). Local mild hypohydration or dehydration may play a critical role in the pathogenesis of several broncho-pulmonary disorders like exercise asthma (IIb) or cystic fibrosis (Ib). In bladder and colon cancers, the evidence on hydration status' effects is inconsistent.

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“…The authors concluded that it was safe for most Muslim renal patients to undertake the Ramadan fast 1 year after kidney transplantation. However, given the deteriorating effect of chronic hypohydration on renal function in animals with impaired renal function (Bouby & Fernandes, 2003), the number of transplanted patients with impaired but stable renal function is probably too small to draw definite conclusions.…”

Section: Renal Transplant Patientsmentioning

confidence: 99%

Effects on health of fluid restriction during fasting in Ramadan

2003

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During the 9th month (Ramadan) of the Islamic calendar (Hijra) many millions of adult Muslims all over the world fast during the daylight hours. Since Hijra is a lunar calendar, Ramadan occurs at different times in the seasonal year over a 33-year cycle. Fasting during Ramadan is partial because the abstention from food, fluid, tobacco and caffeine is from sunrise to sunset. Several categories of people are exempt or can postpone the Ramadan fast. The effect on health and well being of the month-long intermittent fast and fluid restriction has been studied in various potentially vulnerable groups in addition to normal healthy individuals in many countries. The majority of the studies have found significant metabolic changes, but few health problems arising from the fast. A reduction in drug compliance was an inherent negative aspect of the fast. Common findings of the studies reviewed were increased irritability and incidences of headaches with sleep deprivation and lassitude prevalent. A small body mass loss is a frequent, but not universal, outcome of Ramadan. During the daylight hours of Ramadan fasting, practising Muslims are undoubtedly dehydrating, but it is not clear whether they are chronically hypohydrated during the month of Ramadan. No detrimental effects on health have as yet been directly attributed to negative water balance at the levels that may be produced during Ramadan.

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Mild dehydration, vasopressin and the kidney: animal and human studies

Cited by 56 publications

References 40 publications

Diabetes Insipidus: A Review

Diabetes Insipidus: A Review

Hydration and Disease

Effects on health of fluid restriction during fasting in Ramadan

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