Mild cognitive impairment with subcortical vascular features

Frisoni, Giovanni B.; Galluzzi, Samantha; Bresciani, Lorenzo; Zanetti, Orazio; Geroldi, Cristina

doi:10.1007/s00415-002-0861-7

Cited by 146 publications

(135 citation statements)

References 48 publications

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“…This difference could be due to the disease stage. In fact, VaD patients are generally at a later stage of cognitive decline than MCI patients, and it is widely accepted that the subcortical vascular disease has a progressive course in the ultrastructural nature of lesions, as well as in the global load of CV damage (Frisoni et al, 2002). So, the IAF slowing could represent a subsequent change, due to a greater involvement of white matter pathways, during the course of disease.…”

Section: Eeg Frequency Indices Of a Rhythms And CV Damagementioning

confidence: 99%

“…Among these, amnestic MCI (aMCI), characterized by memory deficit and preserved general cognition, is the most clearly defined. Anyway, the natural history of a group of subjects at very high-risk for developing dementia due to subcortical vascular damage [subcortical vascular MCI (svMCI)] has recently been described (Frisoni et al, 2002;Galluzzi et al, 2005). In such study, MCI patients with CV etiology developed a distinctive clinical phenotype characterized by poor performance on frontal tests, and neurological features of parkinsonism without tremor (impairment of balance and gait).…”

Section: Introductionmentioning

confidence: 99%

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Vascular damage and EEG markers in subjects with mild cognitive impairment

Moretti

Miniussi

Frisoni

et al. 2007

Clinical Neurophysiology

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Objective: We evaluated the changes induced by cerebrovascular (CV) damage on brain rhythmicity recorded by electroencephalography (EEG) in a cohort of subjects with mild cognitive impairment (MCI). Methods: We enrolled 99 MCI subjects (Mini-Mental State Examination [MMSE] mean score 26.6). All subjects underwent EEG recording and magnetic resonance imaging (MRI). EEGs were recorded at rest. Individual EEG frequencies were indexed by the h/a transition frequency (TF) and by the individual a frequency (IAF) with power peak in the extended a range (5-14 Hz). Relative power was separately computed for d, h, a1, a2, and a3 frequency bands on the basis of the TF and IAF values. Subsequently, we divided the cohort in four sub-groups based on subcortical CV damage as scored by the age-related white matter changes scale (ARWMC). Results: CV damage was associated with 'slowing' of TF proportional to its severity. In the spectral bandpower the severity of vascular damage was associated with increased d power and decreased a2 power. No association of vascular damage was observed with IAF and a3 power. Moreover, the h/a1 ratio could be a reliable index for the estimation of the individual extent of CV damage. Conclusions: EEG analysis may show physiological markers sensitive to CV damage. The appropriate use of this EEG index may help the differential diagnosis of different forms of cognitive decline, namely primary degenerative and secondary to CV damage. Significance: The EEG neurophysiological approach, together with anatomical features from imaging, could be helpful in the understanding of the functional substrate of dementing disorders.

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Section: Eeg Frequency Indices Of a Rhythms And CV Damagementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vascular damage and EEG markers in subjects with mild cognitive impairment

Moretti

Miniussi

Frisoni

et al. 2007

Clinical Neurophysiology

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“…The predementia stage of SVaD (Frisoni, Galluzzi, Bresciani, Zanetti, & Geroldi, 2002;Galluzzi, Sheu, Zanetti, & Frisoni, 2005), called subcortical vascular mild cognitive impairment (svMCI), is also caused by cerebral small vessel abnormalities. Detecting svMCI patients on magnetic resonance imaging (MRI), multiple lacunar infarctions and white matter hyperintensities (WMH) can be found (Noh et al, 2014;Yi et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Cerebral gray matter volume reduction in subcortical vascular mild cognitive impairment patients and subcortical vascular dementia patients, and its relation with cognitive deficits

Meng

Wang

et al. 2017

Brain and Behavior

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“…Mild cognitive impairment of the vascular type (MCI-V) identifies a population of nondemented patients exhibiting cognitive impairment mainly as a prominent dysexecutive syndrome and clinical and radiological manifestations of subcortical cerebrovascular disease [1, 2]. Epidemiological studies have reported that one fourth of elderly patients meet criteria for dementia 3 months after ischemic stroke [3].…”

Section: Introductionmentioning

confidence: 99%

Mild Cognitive Impairment after Lacunar Infarction: Voxel-Based Morphometry and Neuropsychological Assessment

et al. 2007

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Background: The aim of the present study was to investigate whether there were differences in neuroradiological features, including white-matter lesions and gray-matter volumes, between patients with lacunar infarction with and without mild cognitive impairment of the vascular type (MCI-V). Methods: A total of 40 patients with lacunar infarction were studied within 1 month after stroke. Results: MCI-V was found in 22 patients, who in comparison with patients without cognitive impairment were significantly older and had fewer years of formal education. MRI subcortical hyperintensities especially in the basal ganglia (putamen and thalamus) were significantly more frequent in the MCI-V group. In the voxel-based morphometric study, patients with MCI-V showed more atrophy bilaterally in the middle temporal gyrus, right and left frontal and posterior bilateral occipitoparietal regions including the posterior cingulate as well as in the cerebellum. A region of interest analysis restricted to the parahippocampi and hippocampi showed further reduced bilateral parahippocampal gyrus and right hippocampus volume reductions in this group of patients. Finally, the amount of white-matter lesions among MCI-V showed negative correlations with gray-matter volume in frontal and temporal areas as well as with the thalamus and mesencephalon. Conclusions: The present findings provide support for an anatomical substrate of the MCI entity in patients with lacunar infarction. Both gray- and white-matter changes seem to contribute to the cognitive impairment of such patients.

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Mild cognitive impairment with subcortical vascular features

Abstract: Patients with MCI-V have a distinctive clinical picture and can be identified in a clinical setting. Because of the high frequency of adverse outcomes, very early preventive measures need to be devised.

Cited by 146 publications

References 48 publications

Vascular damage and EEG markers in subjects with mild cognitive impairment

Vascular damage and EEG markers in subjects with mild cognitive impairment

Cerebral gray matter volume reduction in subcortical vascular mild cognitive impairment patients and subcortical vascular dementia patients, and its relation with cognitive deficits

Mild Cognitive Impairment after Lacunar Infarction: Voxel-Based Morphometry and Neuropsychological Assessment

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