Mild cognitive impairment in type 2 diabetes mellitus and related risk factors: a review

Yuan, Xiao-Ying; Wang, Xugang

doi:10.1515/revneuro-2017-0016

Cited by 71 publications

(54 citation statements)

References 67 publications

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“…19 Tau hyperphosphorylation, an important pathological feature of AD, which may lead to cognitive dysfunction. 20 Tau hyperphosphorylation has also been confirmed to be involved in the occurrence of diabetic cognitive dysfunction. 21 Based on these findings, NSE may be associated with cognitive impairment, but the underlying mechanism of this relationship is unclear.…”

Section: Discussionmentioning

confidence: 98%

<p>High Serum Neuron-Specific Enolase Level Is Associated with Mild Cognitive Impairment in Patients with Diabetic Retinopathy</p>

Yu¹,

Liu²,

Li³

et al. 2020

DMSO

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Diabetic retinopathy (DR) can increase the risk of mild cognitive impairment (MCI), which has been confirmed by previous researches. With the frequent occurrence of MCI in patients with DR, the early detection of MCI has become a research hot-spot. The aim of this study was to investigate the relationship between neuron-specific enolase (NSE) and MCI in patients with DR. Patients and Methods: A total of 124 patients with DR, including 56 MCI patients and 68 normal cognition patients, were recruited in this cross-sectional study. The demographic and clinical data of patients were collected through questionnaires. Serum NSE was measured using electrochemiluminescence immunoassay. The Minimum Mental State Examination (MMSE) scale was used to evaluate the cognitive function of the participants. Results: Compared with the normal cognition group, serum NSE levels and HbA1c levels in the MCI group were higher, while MMSE scores and educational level were lower (P<0.05). Serum NSE levels were significantly negatively correlated with MMSE total score, attention and calculation score, and language score (P<0.05). After adjusting for confounding factors, serum NSE still increased the MCI risk in DR patients (OR:1.606, 95CI%:1.264-2.041, P<0.001). The areas under the receiver operating characteristics (ROC) curves (AUC) of the crude model and the adjusted model were 0.75 and 0.73, respectively. Conclusion: A high serum NSE level is an independent risk factor for MCI in DR patients. In addition, serum NSE is expected to be a potential biomarker in DR patients with MCI.

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Section: Discussionmentioning

confidence: 98%

<p>High Serum Neuron-Specific Enolase Level Is Associated with Mild Cognitive Impairment in Patients with Diabetic Retinopathy</p>

Yu¹,

Liu²,

Li³

et al. 2020

DMSO

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“…Abnormal glucose tolerance, a characteristic of prediabetes and T2D, has been related to an increased risk of cognitive impairment and dementia compared with healthy peers [ 41 – 43 ]. Regular exercise has potential therapeutic effects on cognitive function compromised by T2D and Alzheimer’s disease (AD) pathology [ 41 – 45 ].…”

Section: Discussionmentioning

confidence: 99%

Exercise or physical activity and cognitive function in adults with type 2 diabetes, insulin resistance or impaired glucose tolerance: a systematic review

Zhao

O’Sullivan

Singh

2018

Eur Rev Aging Phys Act

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BackgroundDiabetes is an important risk factor for cognitive impairment. Although some studies suggest that physical exercise can minimize age-related cognitive declines or improve brain morphology or function, benefits in diabetes or impaired glucose tolerance are unclear. Therefore, our aim was to evaluate the efficacy of exercise or physical activity on cognition in adults with type 2 diabetes, insulin resistance or impaired glucose tolerance.MethodsAn electronic search for studies published from the earliest record until February 2017 was conducted using Medline, EMBASE, SPORTDiscus, CINAHL, and PsycINFO. Any experimental or observational study designs were included, as long as they were conducted in individuals of any age with type 2 diabetes, insulin resistance or impaired glucose tolerance, and they directly examined exercise/physical activity effects on cognitive outcomes or the relationship between changes in cognition and changes in either insulin resistance and glucose homeostasis. Study quality was assessed using the PEDro scale; data on participant and intervention characteristics and outcomes were extracted.ResultsSix studies enrolling 2289 participants met the eligibility criteria. Quality was modest and effect sizes variable and mostly small or negligible. Overall, four of the six studies (67%) reported significant benefits of greater exercise/physical activity participation for some aspects of cognition, but only 26% of cognitive outcomes were significant across all trials. Clinical improvements in insulin resistance/glucose homeostasis were related to improvements in cognitive function in three studies. Overall results were inconsistent, with benefits varying across exercise types and cognitive domains.ConclusionsLiterature does not provide evidence that physical activity or exercise interventions contribute to a better cognitive function in patients with type 2 diabetes or impaired glucose tolerance. Large-scale, long-term, robust randomized controlled trials are required to determine if exercise improves cognition in this high-risk cohort, and to investigate putative mechanistic links between cognition, body composition, metabolism, and inflammation in diabetes and related metabolic syndromes.

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“…Some pathologies such as diabetes, alpha‐synucleinopathies, and sarcoidosis are common causes for autonomic neuropathy, and OH is prevalent among these diseases . Furthermore, these pathologies may also impair cognitive function by various mechanisms . There are studies examining the relationship between OH and cognitive function among diabetes, alpha‐synucleinopathies, and sarcoidosis participants .…”

Section: Discussionmentioning

confidence: 99%

“…41,42 Furthermore, these pathologies may also impair cognitive function by various mechanisms. [43][44][45][46] There are studies examining the relationship between OH and cognitive function among diabetes, alpha-synucleinopathies, and sarcoidosis participants. 47,48 Here, we demonstrated some findings about the relationship between to OH status or adjusted in the statistics models.…”

Section: Discussionmentioning

confidence: 99%

The association between orthostatic hypotension and dementia: A meta‐analysis of prospective cohort studies

Min

Shi

Sun

et al. 2018

Int J Geriat Psychiatry

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Objectives As for the association between orthostatic hypotension (OH) and dementia, results of published studies are inconsistent; therefore, current substantive conclusions have yet been obtained. This meta‐analysis was conducted in hopes of producing progress in this topic. Methods A systematic database search was performed towards electronic databases including Chinese Biomedical Database, PubMed, Web of Science, Wiley Online Library, ScienceDirect, and the Cochrane Library. Five prospective cohort studies were included. Summary hazard ratio (HR) estimates with 95% confidence intervals (CIs) were calculated by random‐effects model. Statistical heterogeneity was assessed with the Cochran Q test and I2 statistic. A sensitivity analysis was also conducted in this meta‐analysis. Results A 22.4% higher prevalence of dementia in subjects with OH was obtained (adjusted pooled HR was 1.224; 95% CI: 1.106‐1.354; P < .001). This meta‐analysis also showed significant associations between OH and 2 dementia subtypes: Alzheimer disease (adjusted pooled HR was 1.175; 95% CI: 1.022‐1.351; P = .023) and Vascular dementia (adjusted pooled HR was 1.403; 95% CI: 1.042‐1.889; P = .026), respectively. Conclusions Orthostatic hypotension is positively associated with the overall prevalence of dementia, and it may contribute to the prevalence of Alzheimer disease and Vascular dementia as well.

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Mild cognitive impairment in type 2 diabetes mellitus and related risk factors: a review

Cited by 71 publications

References 67 publications

<p>High Serum Neuron-Specific Enolase Level Is Associated with Mild Cognitive Impairment in Patients with Diabetic Retinopathy</p>

<p>High Serum Neuron-Specific Enolase Level Is Associated with Mild Cognitive Impairment in Patients with Diabetic Retinopathy</p>

Exercise or physical activity and cognitive function in adults with type 2 diabetes, insulin resistance or impaired glucose tolerance: a systematic review

The association between orthostatic hypotension and dementia: A meta‐analysis of prospective cohort studies

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