Mild Cognitive Impairment in Moderate to Severe COPD

Villeneuve, Sylvia; Pepin, Véronique; Rahayel, Shady; Bertrand, Jean‐Marie; Lorimier, Myriam de; Rizk, Amanda; Desjardins, Catherine; Parenteau, Simon; Beaucage, François; Joncas, Steve; Monchi, Oury; Gagnon, Jean‐François

doi:10.1378/chest.11-3035

Cited by 145 publications

(151 citation statements)

References 37 publications

Supporting

Mentioning

132

Contrasting

Unclassified

Order By: Relevance

“…A study involving 45 subjects with moderate to severe COPD and 50 healthy controls found that mild cognitive impairment was present in 36% (16 of 45) of subjects with COPD, in comparison with 12% (6 of 50) of control subjects. 23 In a study evaluating the prognostic role of cognitive impairment in subjects with severe COPD, the prevalence of overall cognitive impairment, as defined by MMSE, was 10.4%. 4 Clearly, a significant discrepancy is present within this limited number of studies.…”

Section: Discussionmentioning

confidence: 99%

“…Consistent with these observations, a study in 45 subjects with moderate to severe COPD found superiority of MoCA over MMSE in detecting mild cognitive impairment. 23 Use of different cognitive tests was associated with a difference in study results. Previous studies on the relationship between cognitive function and COPD generally yielded conflicting results.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Factors Influencing Cognitive Function in Subjects With COPD

Dağ¹,

Bulcun

Türkel³

et al. 2016

Respir Care

View full text Add to dashboard Cite

BACKGROUND: The aim of this study was to assess the association between cognitive function and age, pulmonary function, comorbidity index, and the 6-min walk distance in subjects with COPD as well as to compare the Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) in terms of their ability to identify cognitive dysfunction in subjects with COPD. METHODS: A total of 52 individuals with stable COPD were included in this study. Cognitive function was assessed using MMSE and MoCA. Age, body mass index, the Modified Cumulative Illness Rating Scale, 6-min walk distance, arterial blood gases, and pulmonary function tests were assessed and recorded. RESULTS: The range and SD of scores in subjects with COPD were larger with MoCA than with MMSE. MMSE and MoCA scores are associated with 6-min walk distance and comorbidity index in subjects with COPD. General cognitive function measured by MoCA was negatively correlated with the comorbidity index but was positively associated with 6-min walk distance in subjects with COPD after controlling for possible confounding factors in the multivariate model. However, general cognitive function measured by MMSE was not correlated with the comorbidity index and 6-min walk distance in subjects with COPD, after controlling for possible confounding factors in the multivariate model. CONCLUSIONS: MoCA may be a more reliable screening test than MMSE in detecting cognitive impairment in subjects with COPD. The addition of cognitive tests on assessment of subjects with COPD can provide further benefit.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Factors Influencing Cognitive Function in Subjects With COPD

Dağ¹,

Bulcun

Türkel³

et al. 2016

Respir Care

View full text Add to dashboard Cite

show abstract

“…Using the same standardized test battery, we assessed 14 separate patients on the lung transplant waiting list (pretransplant control subjects) to contextualize the results of the post-transplant group. We used a battery of validated and standardized tests to assess cognition (21)(22)(23), anxiety, depression, post-traumatic stress disorder (PTSD) (24)(25)(26)(27)(28), and healthrelated quality of life (30). In addition, given the inverse relationship between psychological distress and the psychological trait of resilience, we also assessed resilience (29).…”

Section: Study Populationmentioning

confidence: 99%

“…We assessed cognition using the Montreal Cognitive Assessment (MoCA), a valid and sensitive screening tool with precedent in patients with advanced lung disease (21)(22)(23). The MoCA required approximately 10 minutes to complete.…”

Section: Study Populationmentioning

confidence: 99%

Cognitive Function, Mental Health, and Health-related Quality of Life after Lung Transplantation

Cohen

Christie²,

Anderson³

et al. 2014

Annals ATS

View full text Add to dashboard Cite

Rationale: Cognitive and psychiatric impairments are threats to functional independence, general health, and quality of life. Evidence regarding these outcomes after lung transplantation is limited.Objectives: Determine the frequency of cognitive and psychiatric impairment after lung transplantation and identify potential factors associated with cognitive impairment after lung transplantation.Methods: In a retrospective cohort study, we assessed cognitive function, mental health, and health-related quality of life using a validated battery of standardized tests in 42 subjects posttransplantation. The battery assessed cognition, depression, anxiety, resilience, and post-traumatic stress disorder (PTSD). Cognitive function was assessed using the Montreal Cognitive Assessment, a validated screening test with a range of 0 to 30. We hypothesized that cognitive function post-transplantation would be associated with type of transplant, cardiopulmonary bypass, primary graft dysfunction, allograft ischemic time, and physical therapy posttransplantation. We used multivariable linear regression to examine the relationship between candidate risk factors and cognitive function post-transplantation.Measurements and Main Results: Mild cognitive impairment (score, 18-25) was observed in 67% of post-transplant subjects (95% confidence interval [CI]: 50-80%) and moderate cognitive impairment (score, 10-17) was observed in 5% (95% CI, 1-16%) of post-transplant subjects. Symptoms of moderate to severe anxiety and depression were observed in 21 and 3% of post-transplant subjects, respectively. No transplant recipients reported symptoms of PTSD. Higher resilience correlated with less psychological distress in the domains of depression (P , 0.001) and PTSD (P = 0.02). Prolonged graft ischemic time was independently associated with worse cognitive performance after lung transplantation (P = 0.001).The functional gain in 6-minute-walk distance achieved at the end of post-transplant physical rehabilitation (P = 0.04) was independently associated with improved cognitive performance post-transplantation.Conclusions: Mild cognitive impairment was present in the majority of patients after lung transplantation. Prolonged allograft ischemic time may be associated with cognitive impairment. Poor physical performance and cognitive impairment are linked, and physical rehabilitation post-transplant and psychological resilience may be protective against the development of long-term impairment. Further study is warranted to confirm these potential associations and to examine the trajectory of cognitive function after lung transplantation.Keywords: lung transplantation; cognitive function; psychological function; quality of life; critical illness

show abstract

“…The MoCA, however, has a higher sensitivity and similar specificity compared to the MMSE for diseases affecting cognition [3]. Previous studies have shown that the MoCA is a better screening method for cognitive impairment due to Parkinson's disease [4], stroke [5], chronic obstructive pulmonary disease [6], heart failure [7], diabetes mellitus with complications [8], and chronic hemodialysis [9]. Despite its global popularity, normative data for the MoCA does not yet exist in Sweden.…”

Section: E Borland Et Al / the Montreal Cognitive Assessmentmentioning

confidence: 99%

[P3–284]: The Montreal Cognitive Assessment: Normative Data From a Large Swedish Population‐based Cohort

Borland¹,

Nägga

Nilsson

et al. 2017

Alzheimer's & Dementia

View full text Add to dashboard Cite

Abstract.Background: The Montreal Cognitive Assessment (MoCA) has a high sensitivity for detecting cognitive dysfunction. Swedish normative data does not exist and international norms are often derived from populations where cognitive impairment has not been screened for and not been thoroughly assessed to exclude subjects with dementia or mild cognitive impairment. Objective: To establish norms for MoCA and develop a regression-based norm calculator based on a large, well-examined cohort. Methods: MoCA was administered on 860 randomly selected elderly people from a population-based cohort from the EPIC study. Cognitive dysfunction was screened for and further assessed at a memory clinic. After excluding cognitively impaired participants, normative data was derived from 758 people, aged 65-85. Results: MoCA cut-offs (-1 to -2 standard deviations) for cognitive impairment ranged from <25 to <21 for the lowest educated and <26 to <24 for the highest educated, depending on age group. Significant predictors for MoCA score were age, sex and level of education. Conclusion: We present detailed normative MoCA data and cut-offs according to the DSM-5 criteria for cognitive impairment based on a large population-based cohort of elderly individuals, screened and thoroughly investigated to rule out cognitive impairment. Level of education, sex, and age should be taken in account when evaluating MoCA score, which is facilitated by our online regression-based calculator that provide percentile and z-score for a subject's MoCA score.

show abstract

Mild Cognitive Impairment in Moderate to Severe COPD

Cited by 145 publications

References 37 publications

Factors Influencing Cognitive Function in Subjects With COPD

Factors Influencing Cognitive Function in Subjects With COPD

Cognitive Function, Mental Health, and Health-related Quality of Life after Lung Transplantation

[P3–284]: The Montreal Cognitive Assessment: Normative Data From a Large Swedish Population‐based Cohort

Contact Info

Product

Resources

About