Mild cognitive impairment in long-term brain tumor survivors following brain irradiation

Cramer, Christina K.; McKee, Neil; Case, L. D.; Chan, Michael D.; Cummings, Tiffany; Lesser, Glenn J.; Shaw, Edward G.; Rapp, Stéphen R.

doi:10.1007/s11060-018-03032-8

Cited by 29 publications

(19 citation statements)

References 35 publications

(35 reference statements)

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“…According to the 2018 report, there were more than 298,000 new cases of brain tumor worldwide ( Bray et al, 2018 ). The progression of the disease is associated with cognitive dysfunction ( Cramer et al, 2019 ). The pathology of the disease is not well classified, and its treatment is still uncertain.…”

Section: Nanotechnology In Brain Diseases and Disordersmentioning

confidence: 99%

The Application of Nanotechnology for the Diagnosis and Treatment of Brain Diseases and Disorders

Ngowi

Wang

Qian

et al. 2021

Front. Bioeng. Biotechnol.

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Brain is by far the most complex organ in the body. It is involved in the regulation of cognitive, behavioral, and emotional activities. The organ is also a target for many diseases and disorders ranging from injuries to cancers and neurodegenerative diseases. Brain diseases are the main causes of disability and one of the leading causes of deaths. Several drugs that have shown potential in improving brain structure and functioning in animal models face many challenges including the delivery, specificity, and toxicity. For many years, researchers have been facing challenge of developing drugs that can cross the physical (blood–brain barrier), electrical, and chemical barriers of the brain and target the desired region with few adverse events. In recent years, nanotechnology emerged as an important technique for modifying and manipulating different objects at the molecular level to obtain desired features. The technique has proven to be useful in diagnosis as well as treatments of brain diseases and disorders by facilitating the delivery of drugs and improving their efficacy. As the subject is still hot, and new research findings are emerging, it is clear that nanotechnology could upgrade health care systems by providing easy and highly efficient diagnostic and treatment methods. In this review, we will focus on the application of nanotechnology in the diagnosis and treatment of brain diseases and disorders by illuminating the potential of nanoparticles.

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Section: Nanotechnology In Brain Diseases and Disordersmentioning

confidence: 99%

The Application of Nanotechnology for the Diagnosis and Treatment of Brain Diseases and Disorders

Ngowi

Wang

Qian

et al. 2021

Front. Bioeng. Biotechnol.

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“…Although the adult brain is considered more resilient in comparison to the developing brain, recent evidence from cranial radiotherapy patients highlights the impact of highdose exposure on brain morphology and network functionality/connectivity (Ma et al 2017;Jacob et al 2018;Qiu et al 2018;Cramer et al 2019;Huang et al 2019). Further, there is growing evidence that exposure of the adult brain to moderate doses may be detrimental to cognitive functioning.…”

Section: Observations From Human Studiesmentioning

confidence: 99%

The psychological consequences of (perceived) ionizing radiation exposure: a review on its role in radiation-induced cognitive dysfunction

Collett

Craenen

Young

et al. 2020

International Journal of Radiation Biology

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Purpose: Exposure to ionizing radiation following environmental contamination (e.g., the Chernobyl and Fukushima nuclear accidents), radiotherapy and diagnostics, occupational roles and space travel has been identified as a possible risk-factor for cognitive dysfunction. The deleterious effects of high doses (1.0 Gy) on cognitive functioning are fairly well-understood, while the consequences of low (0.1 Gy) and moderate doses (0.1-1.0 Gy) have been receiving more research interest over the past decade. In addition to any impact of actual exposure on cognitive functioning, the persistent psychological stress arising from perceived exposure, particularly following nuclear accidents, may itself impact cognitive functioning. In this review we offer a novel interdisciplinary stance on the cognitive impact of radiation exposure, considering psychological and epidemiological observations of different exposure scenarios such as atomic bombings, nuclear accidents, occupational and medical exposures while accounting for differences in dose, rate of exposure and exposure type. The purpose is to address the question that perceived radiation exposure -even where the actual absorbed dose is 0.0 Gy above background dose -can result in psychological stress, which could in turn lead to cognitive dysfunction. In addition, we highlight the interplay between the mechanisms of perceived exposure (i.e., stress) and actual exposure (i.e., radiation-induced cellular damage), in the generation of radiation-induced cognitive dysfunction. In all, we offer a comprehensive and objective review addressing the potential for cognitive defects in the context of low-and moderate-dose IR exposures. Conclusions: Overall the evidence shows prenatal exposure to low and moderate doses to be detrimental to brain development and subsequent cognitive functioning, however the evidence for adolescent and adult low-and moderate-dose exposure remains uncertain. The persistent psychological stress following accidental exposure to low-doses in adulthood may pose a greater threat to our cognitive functioning. Indeed, the psychological implications for instructed cohorts (e.g., astronauts and radiotherapy patients) is less clear and warrants further investigation. Nonetheless, the psychosocial consequences of low-and moderate-dose exposure must be carefully considered when evaluating radiation effects on cognitive functioning, and to avoid unnecessary harm when planning public health response strategies.

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“…Standardized diagnostic criteria for MCI [72, 75] and AD [76–78] have helped to stimulate, organize, and focus research efforts on AD. Our group recently proposed applying slightly modified MCI NIA-AA criteria to cancer survivors with cognitive dysfunction [79–81]. We then retrospectively reviewed patients enrolled on our phase 3 randomized trial of donepezil versus placebo to estimate the prevalence of MCI in brain tumor survivors.…”

Section: Classification Of Patients With Ricdmentioning

confidence: 99%

Treatment of Radiation-Induced Cognitive Decline in Adult Brain Tumor Patients

Cramer

Cummings

Andrews

et al. 2019

Curr. Treat. Options in Oncol.

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Opinion statement Patients with either primary or metastatic brain tumors quite often have cognitive impairment. Maintaining cognitive function is important to brain tumor patients and a decline in cognitive function is generally accompanied by a decline in functional independence and performance status. Cognitive decline can be a result of tumor progression, depression/anxiety, fatigue/sleep dysfunction, or the treatments they have received. It is our opinion that providers treating brain tumor patients should obtain pre-treatment and serial cognitive testing in their patients and offer mitigating and therapeutic interventions when appropriate. They should also support cognition-focused clinical trials.

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Mild cognitive impairment in long-term brain tumor survivors following brain irradiation

Cited by 29 publications

References 35 publications

The Application of Nanotechnology for the Diagnosis and Treatment of Brain Diseases and Disorders

The Application of Nanotechnology for the Diagnosis and Treatment of Brain Diseases and Disorders

The psychological consequences of (perceived) ionizing radiation exposure: a review on its role in radiation-induced cognitive dysfunction

Treatment of Radiation-Induced Cognitive Decline in Adult Brain Tumor Patients

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