Abstract:Thioethers represent prevalent motifs in highly sought after biologically active small molecules such as active pharma-ceutical ingredients (APIs) and natural products. While nucleophilic aromatic substitution (SNAr) has traditionally been used to synthesize aryl thioethers, modern approaches leverage transition metals to catalyze thermal or photochemical cross-coupling. During platform technology development for photochemical transformations, we uncovered an exceedingly mild thioetherification that does not r… Show more
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