Mikrogyrie infolge cerebraler Speicheldr�senvirusinfektion im Rahmen einer generalisierten Cytomegalie bei einem S�ugling

Perinatal Encephalopathies Caused by Maternal Diseases during Pregnancy

“…These are large intranuclear inclusion bodies sur rounded by clear halos. Besides the changes directly caused by the infec tion, others of a secondary and maldevelopmental character are some times described [9]. This is also of interest in many other infectious peri natal encephalopathies, as will be discussed later.…”

“…in experimental intrauterine starvation [4,8], in human cytomegalic inclusion disease [9], and intrauterine hypoxia [16],…”

Retinoic acid receptors initiate induction of the cytomegalovirus enhancer in embryonal cells.

“…Symptomatic infection of neonates with hCMV predominantly affects the immature nervous system (1)(2)(3)(4)(5)(6). Common congenital abnormalities noted in the brain include microcephaly, hydrocephaly, cerebral necrosis, and microgyria (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Interestingly, vitamin A and its active derivative retinoic acid (RA) can induce a similar pattern of congenital abnormalities, including microcephalic and hydrocephalic malformations (12)(13)(14)(15)(16).…”

Citomegalia e malformações do sistema nervoso central: relato de dois casos associados à agenesia do corpo caloso e encefalopatia cística

“…63 28 . 10 ; aplasia de hemisférios cerebelares e agenesia do bulbo e tracto olfativo 12 ; "encephalodystrophia neonatorum" 1S .…”

“…Nos poucos casos em que se comprovou a citomegalia no sistema nervoso central, pela demonstração de suas inclusões virais próprias, as alterações microscópicas se caracterizam por: (a) preferência das lesões necróticas pelas áreas subependimárias dos ventrículos laterais 12 . 21 28 , num caso tendo sido evidenciadas hemorragias, calcificações e intensa gliose nos bulbos e tractos olfativos 21 ; (c) reação inflamatoria predominante linfocitária nas proximidades das lesões 29 , também e mesmo de neurônios 12 -21 > 47 .…”