Migratory routes and fates of cells transcribing the Wnt‐1 gene in the murine hindbrain

Nichols, David H.; Bruce, Laura L.

doi:10.1002/dvdy.20611

Cited by 63 publications

(79 citation statements)

References 77 publications

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“…Nichols and Bruce generated transgenic mice carrying a Wnt-1 enhancer/ lacZ transgene and observed that the ION was not labeled by ␤-gal in those mice. This indicates that, in the transgenic animals, the activity of the Wnt-1 enhancer is below detectable levels in the region in which CF neurons arise, or the Ptf1a domain (Nichols and Bruce, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Conversely, CF neurons were shown to emerge from a distinct progenitor pool in the hindbrain (Rodriguez and Dymecki, 2000;Nichols and Bruce, 2006). Although their birth place has been suggested to be located in the neuroepithelial region that expresses Wnt-1 (wingless-type MMTV integration site family 1) very weakly but not strongly (Landsberg et al, 2005), the precise location along the dorsoventral axis has not been defined.…”

Section: Introductionmentioning

confidence: 99%

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Origin of Climbing Fiber Neurons and Their Developmental Dependence onPtf1a

Yamada¹,

Terao²,

Terashima³

et al. 2007

J. Neurosci.

106

122

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Climbing fiber (CF) neurons in the inferior olivary nucleus (ION) extend their axons to Purkinje cells, playing a crucial role in regulating cerebellar function. However, little is known about their precise place of birth and developmental molecular machinery. Here, we describe the origin of the CF neuron lineage and the involvement of Ptf1a ( pancreatic transcription factor 1a) in CF neuron development. Ptf1a protein was found to be expressed in a discrete dorsolateral region of the embryonic caudal hindbrain neuroepithelium. Because expression of Ptf1a is not overlapping other transcription factors such as Math1 (mouse atonal homolog 1) and Neurogenin1, which are suggested to define domains within caudal hindbrain neuroepithelium (Landsberg et al., 2005), we named the neuroepithelial region the Ptf1a domain. Analysis of mice that express ␤-galactosidase from the Ptf1a locus revealed that CF neurons are derived from the Ptf1a domain. In contrast, retrograde labeling of precerebellar neurons indicated that mossy fiber neurons are not derived from Ptf1a-expressing progenitors. We could observe a detailed migratory path of CF neurons from the Ptf1a domain to the ION during embryogenesis. In Ptf1a null mutants, putative immature CF neurons produced from this domain were unable to migrate or differentiate appropriately, resulting in a failure of ION formation. Apoptotic cells were observed in the mutant hindbrain. Furthermore, the fate of some cells in the Ptf1a lineage were changed to mossy fiber neurons in Ptf1a null mutants. These findings clarify the precise origin of CF neurons and suggest that Ptf1a controls their fate, survival, differentiation, and migration during development.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Origin of Climbing Fiber Neurons and Their Developmental Dependence onPtf1a

Yamada¹,

Terao²,

Terashima³

et al. 2007

J. Neurosci.

106

122

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“…Previous studies suggested that CN neurons are derived from the neuroepithelium in the embryonic ~r2-5 hindbrain region (Farago et al, 2006;Nichols and Bruce, 2006) and that they arise around…”

Section: Ptf1a Is Expressed In a Discrete Neuroepithelial Region Of Tmentioning

confidence: 99%

“…Histological observations have deduced that a portion of neurons generated from the dorsal hindbrain neuroepithelia migrate tangentially to give rise to CN neurons (Pierce, 1967;Ivanova and Yuasa, 1998). More directly, genetic-fate-mapping studies using transgenic mice confirmed that many CN cells are derived from the dorsal region of the hindbrain neuroepithelia, where the Wnt1 promoter is active (Farago et al, 2006;Nichols and Bruce, 2006). As to the rostrocaudal axis, the origins of CN neurons seem to differ between avians and mammals.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1

et al. 2009

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The cochlear nucleus (CN), which consists of dorsal and ventral cochlear nuclei (DCN and VCN), plays pivotal roles in processing and relaying auditory information to the brain. Although it contains various types of neurons, the origins of the distinct subtypes and their developmental molecular machinery are still elusive. Here we reveal that two basic helix-loop-helix transcription factors play crucial roles in specifying neuron subtypes in the CN. Pancreatic transcription factor 1a (Ptf1a) and atonal homolog 1 (Atoh1) were found to be expressed in discrete dorsolateral regions of the embryonic neuroepithelia of the middle hindbrain (rhombomeres 2-5). Genetic lineage tracing using mice that express Cre recombinase from the Ptf1a locus or under the control of the Atoh1 promoter revealed that inhibitory (GABAergic and glycinergic) or excitatory (glutamatergic) neurons of both DCN and VCN are derived from the Ptf1a-and Atoh1-expressing neuroepithelial regions, respectively. In the Ptf1a or Atoh1 null embryos, production of inhibitory or excitatory neurons, respectively, was severely inhibited in the CN. These findings suggest that inhibitory and excitatory subtypes of CN neurons are defined by Ptf1a and Atoh1, respectively and, furthermore, provide important insights into understanding the machinery of neuron subtype specification in the dorsal hindbrain.

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“…4 a, c and b, d, respectively). The rrl extends from the isthmus to the pontine angle (rhombomeres 1-3) and includes the region at the lateral angle of the 4th ventricle, which was formerly known as the germinal trigone [corresponding to rl of rhombomeres 2 and 3; Nichols and Bruce, 2006], whereas the (caudo)lateral rl lies along the caudolateral rim of the caudal 4th ventricle (rl of rhombomere 4 and beyond). The rrl is much thicker and wider in the platypus (several hundred micrometer in both dorsal and lateral extent compared to !…”

Section: Development Of the Trigeminal Sensory Nuclei In Pre-and Perimentioning

confidence: 99%

Distinct Development of the Trigeminal Sensory Nuclei in Platypus and Echidna

Ashwell¹,

Hardman²

2012

Brain Behav Evol

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Both lineages of the modern monotremes have been reported to be capable of electroreception using the trigeminal pathways and it has been argued that electroreception arose in an aquatic platypus-like ancestor of both modern monotreme groups. On the other hand, the trigeminal sensory nuclear complex of the platypus is highly modified for processing tactile and electrosensory information from the bill, whereas the trigeminal sensory nuclear complex of the short-beaked echidna (Tachyglossus aculeatus) is not particularly specialized. If the common ancestor for both platypus and echidna were an electroreceptively and trigeminally specialized aquatic feeder, one would expect the early stages of development of the trigeminal sensory nuclei in both species to show evidence of structural specialization from the outset. To determine whether this is the case, we examined the development of the trigeminal sensory nuclei in the platypus and short-beaked echidna using the Hill and Hubrecht embryological collections. We found that the highly specialized features of the platypus trigeminal sensory nuclei (i.e. the large size of the principal nucleus and oral part of the spinal trigeminal nuclear complex, and the presence of a dorsolateral parvicellular segment in the principal nucleus) appear around the time of hatching in the platypus, but are never seen at any stage in the echidna. Our findings support the proposition that the modern echidna and platypus are derived from a common ancestor with only minimal trigeminal specialization and that the peculiar anatomy of the trigeminal sensory nuclei in the modern platypus emerged in the ornithorhynchids after divergence from the tachyglossids.

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Migratory routes and fates of cells transcribing the Wnt‐1 gene in the murine hindbrain

Cited by 63 publications

References 77 publications

Origin of Climbing Fiber Neurons and Their Developmental Dependence onPtf1a

Origin of Climbing Fiber Neurons and Their Developmental Dependence onPtf1a

Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1

Distinct Development of the Trigeminal Sensory Nuclei in Platypus and Echidna

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