Migratory Ichthyosiform Dermatosis With Type 2 Diabetes Mellitus and Insulin Resistance

Yosipovitch, Gil; Mevorah, B.; David, Michael; Feinmesser, Maora; Hodak, Emmilia; Gabay, Boaz; Ammash, Jamal; Elias, Peter M.

doi:10.1001/archderm.135.10.1237

Cited by 9 publications

(6 citation statements)

References 20 publications

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“…Previous studies examining basal TEWL in uraemic subjects did not reveal significant differences from healthy controls [16]; however, basal TEWL measurements often do not accurately reflect skin barrier status [23,28]. In the current study, SC integrity and permeability barrier recovery using tape stripping were evaluated.…”

Section: Discussionmentioning

confidence: 89%

“…Skin barrier function is often not accurately reflected by basal TEWL measurements in elderly, neonatal and psychologically stressed subjects as well as in dry, scaly (ichthyotic) and uraemic skin [16,[23][24][25][26][27]. Acute perturbations of the SC followed by an assessment of the kinetics of barrier recovery may yield a more accurate assessment of epidermal barrier function [23,28].…”

Section: Introductionmentioning

confidence: 99%

“…Acute perturbations of the SC followed by an assessment of the kinetics of barrier recovery may yield a more accurate assessment of epidermal barrier function [23,28]. Surprisingly, there is a paucity of published data about skin barrier function in patients with uraemic pruritus.…”

Section: Introductionmentioning

confidence: 99%

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Skin barrier structure and function and their relationship to pruritus in end-stage renal disease

Yosipovitch

Duque

Patel

et al. 2007

Nephrology Dialysis Transplantation

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Background. The relationship between dry skin and uraemic pruritus remains controversial. In addition, there is a lack of published data describing the structure and function of the stratum corneum (SC) in end-stage renal disease (ESRD). The purpose of the present study was to assess the function and structure of the skin barrier in patients with ESRD and to correlate any abnormalities with uraemic pruritus. Methods. Thirty-eight subjects participated in the study; 20 with ESRD and 18 healthy controls. Subjects underwent evaluation of SC integrity and permeability barrier recovery, SC surface pH, pruritus and dry skin. The content of glycerol, an important endogenous humectant, was assessed in D-squame tape strips from seven patients with ESRD. Skin biopsies from six of these patients were examined by electron microscopy using ruthenium tetroxide (Ru0 4 )-post-fixation. Results. Although SC integrity was impaired in ESRD patients (P ¼ 0.001), there were no significant differences in permeability barrier recovery rates between ESRD subjects and controls. However, there was a high significant negative correlation between SC glycerol content and dry skin in the arms of ESRD subjects (r ¼ À0.866, P ¼ 0.01). Yet, there was no consistent correlation between pruritus and either dry skin, SC integrity, glycerol content or surface pH. Electron microscopy revealed no significant ultrastructural abnormalities, with particular reference to the lipid bi-layer.Conclusions. SC integrity, but not permeability barrier recovery, is impaired in dialysis patients. Although dry skin in ESRD is associated with reduced SC glycerol levels, the ultra-structure appears to be unaffected.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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Skin barrier structure and function and their relationship to pruritus in end-stage renal disease

Yosipovitch

Duque

Patel

et al. 2007

Nephrology Dialysis Transplantation

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“…These patients reported intensely pruritic ichthyosis from infancy, long before the onset of diabetes. Moreover, histopathologically these lesions were distinct from acquired ichthyosis or ichthyosis vulgaris (6).…”

Section: Discussionmentioning

confidence: 93%

New‐Onset Ichthyosis and Diabetes in a 14‐Year‐Old

Scheinfeld

Libkind

Freilich

2001

Pediatric Dermatology

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Diabetes has not been linked to acquired ichthyosis or ichthyosis vulgaris. We report a newly diagnosed diabetic 14-year-old girl with bilateral tibial and sacral ichthyosiform plaques and a hemoglobin A1c of 20.1%. The patient had no personal or family history of atopy or ichthyosis and lacked keratosis pilaris or hyperlinear palms. A biopsy specimen of an ichthyosiform plaque showed compact lamellar orthohyperkeratosis and hypogranulosis, histopathology consistent with either ichthyosis vulgaris or acquired ichthyosis. We speculate that our patient's new-onset diabetes induced acquired ichthyosis.

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“…Имеются две публикации, в которых описывается сочетание СД 1-го типа и приобретенного ихтиоза, а также сочетание ихтио-зиформного дерматоза с СД 2-го типа [16,17]. В первой публикации приведено описание 14-летней девушки афроамериканского происхождения, стра-дающей СД 1-го типа в течение 6 мес.…”

Section: проблемы эндокринологии 4 2013unclassified

The combination of two monogenic diseases, congenital lamellar ichthyosis and type 2 MODY diabetes mellitus

Емельянов¹,

Sozaeva²

2013

Probl Endokrinol (Mosk)

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A 16-year old boy, P.E., is described in whom the diagnosis of congenital lamellar ichthyosis was established at birth based on the clinical picture and confirmed by a molecular genetic study. Diabetes mellitus was first suspected at the age of 10 years based on the elevated fasting blood glucose (7.1 mmol/l) and HbA1c (7.4%) levels. The patient's medical history revealed that his maternal grandmother suffered diabetes mellitus and his mother had gestational diabetes during the second pregnancy. The patient presented with impaired carbohydrate tolerance in the absence of insulin resistance. The molecular genetic study of the GCK gene revealed a Gly80Ser mutation in the third exon sequence. We failed to find a report of the combination of congenital lamellar ichthyosis and type 2 MODY diabetes mellitus in the available literature.

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Migratory Ichthyosiform Dermatosis With Type 2 Diabetes Mellitus and Insulin Resistance

Cited by 9 publications

References 20 publications

Skin barrier structure and function and their relationship to pruritus in end-stage renal disease

Skin barrier structure and function and their relationship to pruritus in end-stage renal disease

New‐Onset Ichthyosis and Diabetes in a 14‐Year‐Old

The combination of two monogenic diseases, congenital lamellar ichthyosis and type 2 MODY diabetes mellitus

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