Abstract:A fundamental property of cross-coupling reactions is regiospecificity, meaning that the site of bond formation is determined by the leaving group’s location on the electrophile. Typically, to achieve a different substitution pattern requires synthesis of a new, corresponding starting-material isomer. As an alternative, we proposed the development of cross-coupling variants that afford access to multiple structural isomers from the same coupling partners. Here, we first demonstrate that a bulky palladium catal… Show more
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