Migration Phenomenon in Food Packaging. Food–Package Interactions, Mechanisms, Types of Migrants, Testing and Relative Legislation—A Review

Arvanitoyannis, Ioannis S.; Kotsanopoulos, Konstantinos V

doi:10.1007/s11947-013-1106-8

Cited by 131 publications

(75 citation statements)

References 66 publications

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“…It has been acknowledged that the delivery rate of bioactive compounds from films or edible coatings to food is faster when the release is a consequence of their swelling or dissolution, which is conditioned by the nature of the food matrix in direct contact and the polymer matrix of film or coating . Furthermore, the time and temperature of contact, the polymer matrix (promoting or no interaction) with phenolics via functional groups, the properties (chemical structure and polarity) of the phenolic compounds (migrating substances), and their contents in the edible films have been reported to affect the migration rate through coatings to foods in contact . Additionally, the microstructure of the polymer matrix and the way in which the phenolic compounds are oriented with respect to the food based on their hydrophilic or hydrophobic properties strongly affect their migration and thus their effectiveness in protecting foods in contact.…”

Section: Uses Of Antimicrobial Plant Polyphenols In Foodsmentioning

confidence: 99%

Plant antimicrobial polyphenols as potential natural food preservatives

et al. 2018

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These materials could be an interesting delivery system to improve the stability of phenolics in foods and to improve the shelf life of perishable foods. This review will thus provide an overview of current knowledge of the antimicrobial activity of phenolic-rich plant extracts and of the promises and limits of their exploitation for the preservation of perishable foods. © 2018 Society of Chemical Industry.

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Section: Uses Of Antimicrobial Plant Polyphenols In Foodsmentioning

confidence: 99%

Plant antimicrobial polyphenols as potential natural food preservatives

et al. 2018

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“…), and 3% acetic acid (aq.) [8][9][10][11]. The food simulants extracts of the polymer were directly analyzed in LC-MS/MS under ESI negative mode.…”

Section: Introductionmentioning

confidence: 99%

Liquid chromatography with tandem mass spectrometry method for trace level analysis of migrated secondary alkanesulfonate from poly(tetramethylene terephthalate) into food simulants

Ramesh¹,

Kumar²,

Vanderweele

et al. 2019

J of Separation Science

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Secondary alkanesulfonate has been widely used as an antistatic additive in polymers for producing anti‐dust food packaging containers. Currently, no reported method exists for accurate quantification of secondary alkanesulfonate in ethanolic and acidic food simulants. A new liquid chromatography with tandem mass spectrometry method was developed to quantify the migrated amount of secondary alkanesulfonate at trace levels in food simulants from a poly(tetramethylene terephthalate) containing secondary alkanesulfonate. The poly(tetramethylene terephthalate) samples loaded with the antistatic additive were exposed to various food simulants. The collected extracts were directly analyzed by liquid chromatography with tandem mass spectrometry in electrospray ionization negative mode. As secondary alkanesulfonate is a mixture containing C14 to C17 chain lengths, it was separated on a Poroshell 120 EC‐C8 column adopting methanol water gradient program. The migration of secondary alkanesulfonate ranged from 58 to 329 ppb; which is well within the allowed permissible regulatory limits and the adopted method was validated by conducting spiking studies and acceptable recoveries were obtained. The developed method was not only sensitive to detect lower levels of the migrated antistatic additive, but it also avoided more cumbersome sample preparation methodologies like sample enrichment and other derivatization approaches.

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“…In this work, we present a high-throughput, screening-level exposure prediction framework that integrates these data streams. Several computational and experimental approaches have been used to measure and predict migration, which determines resulting chemical concentrations in foods (Bhunia et al, 2013; Arvanitoyannis and Bosnea, 2004; Arvanitoyannis and Kotsanopoulos, 2014). The kinetics of chemical migration depend on food storage conditions (e.g., temperature and duration of food contact with packaging), FCS-specific properties (e.g., material type, thickness, the initial concentration of the migrant), migrant-specific chemical properties, and properties of the food (e.g., fatty or aqueous) (Bhunia et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

High-throughput dietary exposure predictions for chemical migrants from food contact substances for use in chemical prioritization

Biryol

Nicolas

Wambaugh

et al. 2017

Environment International

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Under the ExpoCast program, United States Environmental Protection Agency (EPA) researchers have developed a high-throughput (HT) framework for estimating aggregate exposures to chemicals from multiple pathways to support rapid prioritization of chemicals. Here, we present methods to estimate HT exposures to chemicals migrating into food from food contact substances (FCS). These methods consisted of combining an empirical model of chemical migration with estimates of daily population food intakes derived from food diaries from the National Health and Nutrition Examination Survey (NHANES). A linear regression model for migration at equilibrium was developed by fitting available migration measurements as a function of temperature, food type (i.e., fatty, aqueous, acidic, alcoholic), initial chemical concentration in the FCS (C0) and chemical properties. The most predictive variables in the resulting model were C0, molecular weight, log Kow, and food type (R2 = 0.71, p < 0.0001). Migration-based concentrations for 1009 chemicals identified via publicly-available data sources as being present in polymer FCSs were predicted for 12 food groups (combinations of 3 storage temperatures and food type). The model was parameterized with screening-level estimates of C0 based on the functional role of chemicals in FCS. By combining these concentrations with daily intakes for food groups derived from NHANES, population ingestion exposures of chemical in mg/kg-bodyweight/day (mg/kg-BW/day) were estimated. Calibrated aggregate exposures were estimated for 1931 chemicals by fitting HT FCS and consumer product exposures to exposures inferred from NHANES biomonitoring (R2 = 0.61, p < 0.001); both FCS and consumer product pathway exposures were significantly predictive of inferred exposures. Including the FCS pathway significantly impacted the ratio of predicted exposures to those estimated to produce steady-state blood concentrations equal to in-vitro bioactive concentrations. While these HT methods have large uncertainties (and thus may not be appropriate for assessments of single chemicals), they can provide critical refinement to aggregate exposure predictions used in risk-based chemical priority–setting.

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Migration Phenomenon in Food Packaging. Food–Package Interactions, Mechanisms, Types of Migrants, Testing and Relative Legislation—A Review

Cited by 131 publications

References 66 publications

Plant antimicrobial polyphenols as potential natural food preservatives

Plant antimicrobial polyphenols as potential natural food preservatives

Liquid chromatography with tandem mass spectrometry method for trace level analysis of migrated secondary alkanesulfonate from poly(tetramethylene terephthalate) into food simulants

High-throughput dietary exposure predictions for chemical migrants from food contact substances for use in chemical prioritization

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