Migration of non intentionally added substances from adhesives by UPLC–Q‐TOF/MS and the role of EVOH to avoid migration in multilayer packaging materials

Abstract

Polyurethane adhesives are commonly used to laminate multilayer packaging materials for food. Since these materials are in direct contact with the food, compounds could migrate from adhesive into it. For this reason, it is important to identify all the potential migrants and verify their migration. Ultra-high performance liquid chromatography-quadrupole time-of-flight-mass spectrometry analyses and ChemSpider database are used to identify the potential migrants from polyurethane adhesives, and these techniques were demonstrated to be very powerful and useful tools for this purpose. Migration tests were carried out using Tenax® as food simulant. Nine out of fifteen non-volatile compounds, identified in the cured adhesives, migrated. Most of them were identified as cyclic compounds, adipic based, which is the most commonly used monomer to make the polyester/polyol resins for polyurethane bi-component adhesives. In this work, the use of EvOH layer in several multilayer materials to minimize or avoid migration was evaluated too.

Compounds from multilayer plastic bags cause reproductive failures in artificial insemination

“…The identification was confirmed by injection of the pure compound isolated from an adhesive. This lactone was also identified in other food packaging materials, and in all cases, the polyurethane adhesive was the source1718. Its structure suggests that it is most likely derived from adipic acid.…”

Advanced Mass Spectrometry

“…Raf. and their bioactivities [92] LC-QqTOF Comprehensive characterization of bioactive phenolic compounds in cucumber whole fruit extract [93] LC-QqTOF Migration of nonintentionally added substances from adhesives and the role of EVOH to avoid migration in multilayer packaging materials [94] SELDI-TOF Analysis of raw hams to predict the final quality of dry-cured hams [43] …”

Risk assessment derived from migrants identified in several adhesives commonly used in food contact materials

“…Besides, they can also contain impurities from raw materials or by-products as result of a side reaction between different ingredients. These substances are called NIAS (non intentioned added substances) (Felix et al, 2012;Isella et al, 2013) which are unknown by adhesive producers.…”