Migration of Kupffer’s vesicle derived cells is essential for tail morphogenesis in zebrafish embryos
Jelmer Hoeksma,
Jeroen den Hertog
Abstract:A phenotypic screen of fungal filtrates on developing zebrafish embryos identified metabolites from the fungusCeratocystis populicolato induce ectopic tail formation, including a split notochord and a duplicated caudal fin. Chemical analyses led to the identification of monoterpene alcohols, in particular geraniol, as active compounds inducing ectopic tail formation during a specific 4 h time window during tail bud stage. Embryos from Tüpfel long fin zebrafish (TL) were more susceptible to ectopic tail formati… Show more
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