Migration of impurities from a multilayer plastics container into a parenteral infusion fluid

Potential Migration of ε-Caprolactam to Water and Wine as Affected by Transportation and Storage

“…All have identified ε-caprolactam as a principal migrant when Nylon 6 plastic materials have been used to seal, store or cook commodities (Bradley et al, 2004). Due to high cooking temperatures, monomers of Nylon and other constituents of the plastic packaging have been found to migrate to water or the packaged food, and the duration of heating has been positively correlated with ε-caprolactam migration (Gramshaw et al, 1998;Lawson et al, 1996;Sarbach et al, 1996). Results also indicate that solvent type and heating method can affect ε-caprolactam migration.…”

“…It has been common to test bags or pouches for plastics migration directly into foodstuffs or the aqueous solutions surrounding the foods. It was found that heat caused the migration of plastic components into both the food and surrounding solution (Gramshaw et al, 1998;Lawson et al, 1996;Sarbach et al, 1996).…”

“…Ramanathan (2007) reported ε-caprolactam migration to Nylon-6-based plastic bags used for long-term water storage and Sarbach et al (1996) reported ε-caprolactam migration to IV solutions from plastic containers. The bags used in both studies contained Nylon 6 and storage was for nearly two years at ambient temperatures (Sarbach et al, 1996).…”

“…Epsilon-caprolactam was found to be the main migrant from a tri-laminate bag consisting of polypropylene (PP), Nylon-6 (PA) and polyethylene (PE), and containing a parenteral (intravenous (IV)) solution of 0.5% metronidazole (Sarbach et al, 1996). In addition to the ε-caprolactam, other compounds were also detected in the IV solution including methylene dianiline (MDA) and several non-identified compounds thought to be plasticizers used in the manufacture of the bags.…”

“…The bags used in both studies contained Nylon 6 and storage was for nearly two years at ambient temperatures (Sarbach et al, 1996).…”