Migration of IgA-bearing lymphocytes into salivary glands

Jackson, Dianne E.; Lally, Edward T.; Nakamura, Mary C.; Montgomery, P.C.

doi:10.1016/0008-8749(81)90042-3

Cited by 72 publications

(32 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It must be stressed, however, that Streptococcus sp., including faecalis, are predominantly recovered from oral surfaces (particularly from the teeth) and are likely to be permanent residents of the murine oral cavity. It is probable that cross-reacting antigens on faecal strains of Streptococcus can bring a particularly good sensitization to these microorganisms through the GALT via the common mucosal immune system (16,18,24). This is an agreement with high IgA-RI's to S. faecalis but the differential reactivity of salivary IgA with other Streptococcus sp.…”

Section: Discussionmentioning

confidence: 67%

Differential Recognition of Oral Indigenous Bacteria by Salivary Immunoglobulins A and G

Deslauriers

Séguin

Trudel

1987

Microbiology and Immunology

View full text Add to dashboard Cite

Assuming that salivary immunity to indigenous microorganisms could develop, we assessed antibacterial reactivities of natural salivary antibodies in specific pathogen-free inbred mice. An ELISA was set up, using whole bacterial cells, to map reactivities of salivary IgA and IgG which accounted respectively for 91 % and 8.7% of salivary Ig's in the BALB/c mouse. Representative strains of seven species from three genera (Lactobacilli, Staphylococci, and Streptococci), including major and minor components of the murine oral flora (38, 43, and 8%, respectively), were used to determine the presence and level of specific antibodies in individual saliva. It was verified that naturally occurring IgA antibodies can display diverse antibacterial reactivities. A characteristic profile emerged for salivary IgA where antibodies to Streptococcus faecalis predominate. Natural salivary IgG antibodies did not show the same reactivity pattern as IgA, anti-Lactobacilli and anti-Staphylococci reactivities being much less frequent in the salivary IgG repertoire. However, antibodies to S. faecalis occurred at the same high frequency for both isotypes (62-70% of the samples). Besides being species-specific, antibacterial reactivities were also found to be strain-specific. Broad variations in antibacterial titers were detected among individual mice under standardized experimental conditions. Present data thus suggest that the dynamics of salivary antibody production in the mouse reflect a differential natural sensitization of the secretory (IgA) versus the systemic (IgG) immune systems by distinct populations of indigenous bacteria.

show abstract

Section: Discussionmentioning

confidence: 67%

Differential Recognition of Oral Indigenous Bacteria by Salivary Immunoglobulins A and G

Deslauriers

Séguin

Trudel

1987

Microbiology and Immunology

View full text Add to dashboard Cite

show abstract

“…The process which eventually leads to an IgA re sponse after antigen enters the gut involves the hom ing of sensitized IgA precursor lymphocytes from the Peyer's patches through the lymphatics, the blood stream, and eventually to mucosal sites of IgA anti body synthesis [7,13,20]. It has been suggested that the soluble or particulate nature of an antigen may af fect the orally induced IgA response [28], Oral admin istration of the particulate form of an antigen may in duce a greater IgA response due to the greater ability of particulate materials to penetrate the intestine and be taken up by M cells, thereby gaining direct access to Peyer's patches [29][30][31][32].…”

Section: Discussionmentioning

confidence: 99%

“…More specif ically, it has been demonstrated that saliva [I, [6][7][8][9] and milk [10][11][12][13][14] are sources of IgA antibody follow ing ingestion of an antigen. Prior investigations in our laboratory have demonstrated that ingestion of a par ticulate form of a DNP antigen elicits a greater sali vary IgG response than does ingestion of a soluble form [15].…”

Section: Introductionmentioning

confidence: 99%

“…We now know from this ob servation, as well as from subsequent ones of others, that there exists an IgA cell cycle that begins by anti gen sensitization of the lymphoid tissue of the gut, proceeds through the mesenteric lymph nodes [19], the thoracic duct lymph, and the bloodstream to be come distributed in the lamina propria of the gut where these cells now produce IgA antibody [20], The origin of these IgA precursor cells in the lymphoid tis sue of the gut was determined by cell transfer experi ments and proved to be Peyer's patches [19,21,22]. It has since been determined that IgA precursor cells from the lymphoid tissue of the gut are not only cap able of seeding the gut lamina propria but can seed the mammary glands [13] or the salivary glands [7], In this study, we examined the ability of gastric adminis tration of a soluble or a particulate DNP antigen to elicit an increased locally induced secretory antibody response at the mammary gland. We additionally ex amined a secretory site (salivary gland) remote from the site of antigen injection for any effect produced by prior gastric intubation of antigen.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

IgA Antibody Produced by Local Presentation of Antigen in Orally Primed Rats

Cox¹,

Muench²

1984

Int Arch Allergy Immunol

View full text Add to dashboard Cite

The effect of the introduction of antigen by gastric intubation on the locally stimulated mammary gland IgA antibody (Ab) response was examined. Rats receiving a particulate DNP antigen by gastric intubation prior to injection in the vicinity of the mammary glands (MGV) demonstrated increased levels of IgA Ab in milk. Soluble DNP antigen introduction by gastric intubation did not lead to increased IgA Ab levels in milk. Prior administration of either form of DNP antigen by gastric intubation did not affect the IgG response. Only those rats receiving particulate DNP antigen by intubation demonstrated salivary IgA Ab. Particulate forms of antigen administered by intubation can provide a means of increasing the locally induced IgA response at a secretory site.

show abstract

“…The T cells tend to home to submucosal sites in the conjunctiva, whereas B cells home to the lacrimal gland and accessory lacrimal gland epithelia.12 The B cells can produce immunoglobulins at these sites, particularly IgA. 13 In different diseases, different populations of T cells can be seen (i.e. helper cells, sup pressor cells) in the conjunctival submucosal tissueY Foreign substances can be processed locally by the musocal immune defence system.…”

mentioning

confidence: 99%

Cellular response to inflammation at the limbus

Smolin¹

1989

Eye

View full text Add to dashboard Cite

SummaryThe role in ocular (limbal) inflammation of the ric . h vascular and lymphatic supply is discussed in detail. The distribution of lymphocytes, mast cells, Langerhans cells, macrophages and other cellular elements are discussed as well as their individual and collective response to inflammation whether due to infectious or non-infectious disease states. Among the non-infectious causes of Iimbal cellular inflammation are the four types of hypersensitivity response.

show abstract

Migration of IgA-bearing lymphocytes into salivary glands

Cited by 72 publications

References 11 publications

Differential Recognition of Oral Indigenous Bacteria by Salivary Immunoglobulins A and G

Differential Recognition of Oral Indigenous Bacteria by Salivary Immunoglobulins A and G

IgA Antibody Produced by Local Presentation of Antigen in Orally Primed Rats

Cellular response to inflammation at the limbus

Contact Info

Product

Resources

About